Evidence that a protein‐protein interaction ‘hot spot’ on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors
dc.contributor.author | Scott, Jamie K. | en_US |
dc.contributor.author | Huang, Shan‐fu | en_US |
dc.contributor.author | Gangadhar, Beechanahalli P. | en_US |
dc.contributor.author | Samoriski, Gary M. | en_US |
dc.contributor.author | Clapp, Peter | en_US |
dc.contributor.author | Gross, Robert A. | en_US |
dc.contributor.author | Taussig, Ronald | en_US |
dc.contributor.author | Smrcka, Alan V. | en_US |
dc.date.accessioned | 2014-01-08T20:35:07Z | |
dc.date.available | 2014-01-08T20:35:07Z | |
dc.date.issued | 2001-02-15 | en_US |
dc.identifier.citation | Scott, Jamie K.; Huang, Shan‐fu ; Gangadhar, Beechanahalli P.; Samoriski, Gary M.; Clapp, Peter; Gross, Robert A.; Taussig, Ronald; Smrcka, Alan V. (2001). "Evidence that a proteinâ protein interaction â hot spotâ on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors." The EMBO Journal 20(4): 767-776. <http://hdl.handle.net/2027.42/102234> | en_US |
dc.identifier.issn | 0261-4189 | en_US |
dc.identifier.issn | 1460-2075 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/102234 | |
dc.publisher | John Wiley & Sons, Ltd | en_US |
dc.subject.other | G Protein βγ Subunits | en_US |
dc.subject.other | Peptide | en_US |
dc.subject.other | Phage Display | en_US |
dc.subject.other | Protein‐Protein Interaction | en_US |
dc.subject.other | G Protein Effectors | en_US |
dc.title | Evidence that a protein‐protein interaction ‘hot spot’ on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 11179221 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/102234/1/emboj7593582.pdf | |
dc.identifier.doi | 10.1093/emboj/20.4.767 | en_US |
dc.identifier.source | The EMBO Journal | en_US |
dc.identifier.citedreference | Sankaran B, Osterhout J, Wu D and Smrcka AV ( 1998 ) Identification of a structural element in phospholipase C β2 that interacts with G protein βγ subunits. J Biol Chem, 273, 7148 – 7154. | en_US |
dc.identifier.citedreference | Kozasa T and Gilman AG ( 1995 ) Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of α 12 and inhibition of adenylyl cyclase by α z. J Biol Chem, 270, 1734 – 1741. | en_US |
dc.identifier.citedreference | Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L and Clapham DE ( 1998 ) Gβ binding to GIRK4 subunit is critical for G protein‐gated K + channel activation. J Biol Chem, 273, 16946 – 16952. | en_US |
dc.identifier.citedreference | Kuang Y, Wu Y, Jiang H and Wu D ( 1996 ) Selective G protein coupling by C‐C chemokine receptors. J Biol Chem, 271, 3975 – 3978. | en_US |
dc.identifier.citedreference | Li Y, Sternweis PM, Charnecki S, Smith TF, Gilman AG, Neer EJ and Kozasa T ( 1998 ) Sites for G‐α binding on the G protein β subunit overlap with sites for regulation of phospholipase C β and adenylyl cyclase. J Biol Chem, 273, 16265 – 16272. | en_US |
dc.identifier.citedreference | Littman DR ( 1998 ) Chemokine receptors: keys to AIDS pathogenesis ? Cell, 93, 677 – 680. | en_US |
dc.identifier.citedreference | Loew A, Ho YK, Blundell T and Bax B ( 1998 ) Phosducin induces a structural change in transducin βγ. Structure, 6, 1007 – 1019. | en_US |
dc.identifier.citedreference | Lowman HB, Chen YM, Skelton NJ, Mortensen DL, Tomlinson EE, Sadick MD, Robinson IC and Clark RG ( 1998 ) Molecular mimics of insulin‐like growth factor 1 (IGF‐1) for inhibiting IGF‐1: IGF‐binding protein interactions. Biochemistry, 37, 8870 – 8878. | en_US |
dc.identifier.citedreference | Maniatis T, Fritsch E and Sambrook J ( 1991 ) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. | en_US |
dc.identifier.citedreference | Parish CA, Smrcka AV and Rando RR ( 1995 ) Functional significance of βγ subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3‐kinase. Biochemistry, 34, 7722 – 7727. | en_US |
dc.identifier.citedreference | Qin N, Platano D, Olcese R, Stefani E and Birnbaumer L ( 1997 ) Direct interaction of G βγ with a C‐terminal G βγ‐binding domain of the Ca 2+ channel α1 subunit is responsible for channel inhibition by G protein‐coupled receptors. Proc Natl Acad Sci USA, 94, 8866 – 8871. | en_US |
dc.identifier.citedreference | Romoser V, Ball R and Smrcka AV ( 1996 ) Phospholipase C β2 association with phospholipid interfaces assessed by fluorescence resonance energy transfer. G protein βγ subunit‐mediated translocation is not required for enzyme activation. J Biol Chem, 271, 25071 – 25078. | en_US |
dc.identifier.citedreference | Samoriski GM and Gross RA ( 2000 ) Functional compartmentalization of opioid desensitization in primary sensory neurons. J Pharmacol Exp Ther, 294, 500 – 509. | en_US |
dc.identifier.citedreference | Satpaev DK and Slepak VZ ( 2000 ) Analysis of protein‐protein interactions in phototransduction cascade using surface plasmon resonance. Methods Enzymol, 316, 20 – 40. | en_US |
dc.identifier.citedreference | Smigel MD ( 1986 ) Purification of the catalyst of adenylate cyclase. J Biol Chem, 261, 1976 – 1982. | en_US |
dc.identifier.citedreference | Smith GP and Scott JK ( 1993 ) Libraries of peptides and proteins displayed on filamentous phage. Methods Enzymol, 217, 228 – 257. | en_US |
dc.identifier.citedreference | Sprang SR ( 1997 ) G protein mechanisms: insights from structural analysis. Annu Rev Biochem, 66, 639 – 678. | en_US |
dc.identifier.citedreference | Stephens LR et al. ( 1997 ) The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell, 89, 105 – 114. | en_US |
dc.identifier.citedreference | Touhara K, Koch WJ, Hawes BE and Lefkowitz RJ ( 1995 ) Mutational analysis of the pleckstrin homology domain of the β‐adrenergic receptor kinase: differential effects on G βγ and phosphatidylinositol 4,5‐bisphosphate binding. J Biol Chem, 270, 17000 – 17005. | en_US |
dc.identifier.citedreference | Wells JA and de Vos AM ( 1996 ) Hematopoietic receptor complexes. Annu Rev Biochem, 65, 609 – 634. | en_US |
dc.identifier.citedreference | Weng GZ, Li JR, Dingus J, Hildebrandt JD, Weinstein H and Iyengar R ( 1996 ) G‐β subunit interacts with a peptide encoding region 956–982 of adenylyl cyclase 2: cross‐linking of the peptide to free G βγ but not the heterotrimer. J Biol Chem, 271, 26445 – 26448. | en_US |
dc.identifier.citedreference | Wiley JW, Moises HC, Gross RA and Macdonald RL ( 1997 ) Dynorphin A‐mediated reduction in multiple calcium currents involves a G(o) α‐subtype G protein in rat primary afferent neurons. J Neurophysiol, 77, 1338 – 1348. | en_US |
dc.identifier.citedreference | Wrighton NC et al. ( 1996 ) Small peptides as potent mimetics of the protein hormone erythropoietin. Science, 273, 458 – 464. | en_US |
dc.identifier.citedreference | Xie W et al. ( 1999 ) Genetic alteration of phospholipase Cβ3 expression modulates behavioral and cellular responses to μ opioids. Proc Natl Acad Sci USA, 96, 10385 – 10390. | en_US |
dc.identifier.citedreference | Yoshikawa DM, Hatwar M and Smrcka AV ( 2000 ) G protein β 5 subunit interactions with α subunits and effectors. Biochemistry, 39, 11340 – 11347. | en_US |
dc.identifier.citedreference | Bonnycastle LLC, Mehroke JS, Rashed M, Gong X and Scott JK ( 1996 ) Probing the basis of antibody reactivity with a panel of constrained peptide libraries displayed by filamentous phage. J Mol Biol, 258, 747 – 762. | en_US |
dc.identifier.citedreference | Chen J et al. ( 1995 ) A region of adenylyl cyclase 2 critical for regulation by G protein βγ subunits. Science, 268, 1166 – 1169. | en_US |
dc.identifier.citedreference | Clapham DE and Neer EJ ( 1997 ) G protein βγ subunits. Annu Rev Pharmacol Toxicol, 37, 167 – 203. | en_US |
dc.identifier.citedreference | Dingus J, Wilcox MD, Kohnken R and Hildebrandt JD ( 1994 ) Synthesis and use of biotinylated βγ complexes prepared from bovine brain G proteins. Methods Enzymol, 237, 457 – 471. | en_US |
dc.identifier.citedreference | Fairbrother WJ et al. ( 1998 ) Novel peptides selected to bind vascular endothelial growth factor target the receptor‐binding site. Biochemistry, 37, 17754 – 17764. | en_US |
dc.identifier.citedreference | Gaudet R, Bohm A and Sigler PB ( 1996 ) Crystal structure at 2.4 Å resolution of the complex of transducin βγ and its regulator, phosducin. Cell, 87, 577 – 588. | en_US |
dc.identifier.citedreference | Geysen HM, Meloen RH and Barteling SJ ( 1984 ) Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc Natl Acad Sci USA, 81, 3998 – 4002. | en_US |
dc.identifier.citedreference | Gutkind JS ( 1998 ) The pathways connecting G protein coupled receptors to the nucleus through divergent mitogen‐activated protein kinase cascades. J Biol Chem, 273, 1839 – 1842. | en_US |
dc.identifier.citedreference | Hamm HE ( 1998 ) The many faces of G protein signaling. J Biol Chem, 273, 669 – 672. | en_US |
dc.identifier.citedreference | Herlitze S, Garcia DE, Mackie K, Hille B, Scheuer T and Catterall WA ( 1996 ) Modulation of Ca 2+ channels by G‐protein βγ subunits. Nature, 380, 258 – 262. | en_US |
dc.identifier.citedreference | Herlitze S, Hockerman GH, Scheuer T and Catterall WA ( 1997 ) Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel α1A subunit. Proc Natl Acad Sci USA, 94, 1512 – 1516. | en_US |
dc.identifier.citedreference | Hildebrandt JD ( 1997 ) Role of subunit diversity in signaling by heterotrimeric G proteins. Biochem Pharmacol, 54, 325 – 339. | en_US |
dc.identifier.citedreference | Jiang H, Kuang Y, Wu Y, Xie W, Simon MI and Wu D ( 1997 ) Roles of phospholipase C β2 in chemoattractant‐elicited responses. Proc Natl Acad Sci USA, 94, 7971 – 7975. | en_US |
dc.identifier.citedreference | Koch WJ, Inglese J, Stone WC and Lefkowitz RJ ( 1993 ) The binding site for the βγ subunits of heterotrimeric G proteins on the β‐adrenergic receptor kinase. J Biol Chem, 268, 8256 – 8260. | en_US |
dc.identifier.citedreference | Kohnken RE and Hildebrandt JD ( 1989 ) G protein subunit interactions: studies with biotinylated G protein subunits. J Biol Chem, 264, 20688 – 20696. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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