Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
dc.contributor.author | Ikenoue, Tsuneo | en_US |
dc.contributor.author | Inoki, Ken | en_US |
dc.contributor.author | Yang, Qian | en_US |
dc.contributor.author | Zhou, Xiaoming | en_US |
dc.contributor.author | Guan, Kun‐liang | en_US |
dc.date.accessioned | 2014-01-08T20:35:07Z | |
dc.date.available | 2014-01-08T20:35:07Z | |
dc.date.issued | 2008-07-23 | en_US |
dc.identifier.citation | Ikenoue, Tsuneo; Inoki, Ken; Yang, Qian; Zhou, Xiaoming; Guan, Kun‐liang (2008). "Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling." The EMBO Journal 27(14): 1919-1931. <http://hdl.handle.net/2027.42/102236> | en_US |
dc.identifier.issn | 0261-4189 | en_US |
dc.identifier.issn | 1460-2075 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/102236 | |
dc.publisher | John Wiley & Sons, Ltd | en_US |
dc.subject.other | TORC2 | en_US |
dc.subject.other | PKC | en_US |
dc.subject.other | MTOR | en_US |
dc.subject.other | Akt | en_US |
dc.title | Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 18566587 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/102236/1/emboj2008119-sup-0001.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/102236/2/emboj2008119.pdf | |
dc.identifier.doi | 10.1038/emboj.2008.119 | en_US |
dc.identifier.source | The EMBO Journal | en_US |
dc.identifier.citedreference | Parekh DB, Ziegler W, Parker PJ ( 2000 ) Multiple pathways control protein kinase C phosphorylation. EMBO J 19: 496 – 503 | en_US |
dc.identifier.citedreference | Lawlor MA, Alessi DR ( 2001 ) PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114: 2903 – 2910 | en_US |
dc.identifier.citedreference | Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ ( 1998 ) Protein kinase C isotypes controlled by phosphoinositide 3‐kinase through the protein kinase PDK1. Science 281: 2042 – 2045 | en_US |
dc.identifier.citedreference | Leontieva OV, Black JD ( 2004 ) Identification of two distinct pathways of protein kinase Calpha down‐regulation in intestinal epithelial cells. J Biol Chem 279: 5788 – 5801 | en_US |
dc.identifier.citedreference | Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN ( 2002 ) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10: 457 – 468 | en_US |
dc.identifier.citedreference | Mellor H, Parker PJ ( 1998 ) The extended protein kinase C superfamily. Biochem J 332 (Part 2): 281 – 292 | en_US |
dc.identifier.citedreference | Mora A, Komander D, van Aalten DM, Alessi DR ( 2004 ) PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 15: 161 – 170 | en_US |
dc.identifier.citedreference | Newton AC ( 2003 ) Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370: 361 – 371 | en_US |
dc.identifier.citedreference | Parekh D, Ziegler W, Yonezawa K, Hara K, Parker PJ ( 1999 ) Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon. J Biol Chem 274: 34758 – 34764 | en_US |
dc.identifier.citedreference | Sabatini DM ( 2006 ) mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6: 729 – 734 | en_US |
dc.identifier.citedreference | Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument‐Bromage H, Tempst P, Sabatini DM ( 2004 ) Rictor, a novel binding partner of mTOR, defines a rapamycin‐insensitive and raptor‐independent pathway that regulates the cytoskeleton. Curr Biol 14: 1296 – 1302 | en_US |
dc.identifier.citedreference | Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM ( 2006 ) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22: 159 – 168 | en_US |
dc.identifier.citedreference | Sarbassov DD, Guertin DA, Ali SM, Sabatini DM ( 2005 ) Phosphorylation and regulation of Akt/PKB by the rictor–mTOR complex. Science 307: 1098 – 1101 | en_US |
dc.identifier.citedreference | Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA ( 2006 ) Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11: 583 – 589 | en_US |
dc.identifier.citedreference | Stumpo DJ, Graff JM, Albert KA, Greengard P, Blackshear PJ ( 1989 ) Molecular cloning, characterization, and expression of a cDNA encoding the ‘80‐ to 87‐kDa’ myristoylated alanine‐rich C kinase substrate: a major cellular substrate for protein kinase C. Proc Natl Acad Sci USA 86: 4012 – 4016 | en_US |
dc.identifier.citedreference | Toker A ( 1998 ) Signaling through protein kinase C. Front Biosci 3: D1134 – D1147 | en_US |
dc.identifier.citedreference | Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH ( 2007 ) Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9: 316 – 323 | en_US |
dc.identifier.citedreference | Wullschleger S, Loewith R, Hall MN ( 2006 ) TOR signaling in growth and metabolism. Cell 124: 471 – 484 | en_US |
dc.identifier.citedreference | Yang Q, Inoki K, Ikenoue T, Guan KL ( 2006 ) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20: 2820 – 2832 | en_US |
dc.identifier.citedreference | Zhang J, Wang L, Schwartz J, Bond RW, Bishop WR ( 1994 ) Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation. J Biol Chem 269: 19578 – 19584 | en_US |
dc.identifier.citedreference | Ziegler WH, Parekh DB, Le Good JA, Whelan RD, Kelly JJ, Frech M, Hemmings BA, Parker PJ ( 1999 ) Rapamycin‐sensitive phosphorylation of PKC on a carboxy‐terminal site by an atypical PKC complex. Curr Biol 9: 522 – 529 | en_US |
dc.identifier.citedreference | Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA ( 1996 ) Mechanism of activation of protein kinase B by insulin and IGF‐1. EMBO J 15: 6541 – 6551 | en_US |
dc.identifier.citedreference | Alessi DR, Cohen P ( 1998 ) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8: 55 – 62 | en_US |
dc.identifier.citedreference | Behn‐Krappa A, Newton AC ( 1999 ) The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Curr Biol 9: 728 – 737 | en_US |
dc.identifier.citedreference | Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P ( 1998 ) Akt activation by growth factors is a multiple‐step process: the role of the PH domain. Oncogene 17: 313 – 325 | en_US |
dc.identifier.citedreference | Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence Jr JC, Abraham RT ( 1996 ) Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002. EMBO J 15: 5256 – 5267 | en_US |
dc.identifier.citedreference | Cenni V, Doppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A ( 2002 ) Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J 363: 537 – 545 | en_US |
dc.identifier.citedreference | Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A ( 1998 ) Regulation of protein kinase C zeta by PI 3‐kinase and PDK‐1. Curr Biol 8: 1069 – 1077 | en_US |
dc.identifier.citedreference | Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR ( 2003 ) In vivo role of the PIF‐binding docking site of PDK1 defined by knock‐in mutation. EMBO J 22: 4202 – 4211 | en_US |
dc.identifier.citedreference | Dutil EM, Toker A, Newton AC ( 1998 ) Regulation of conventional protein kinase C isozymes by phosphoinositide‐dependent kinase 1 (PDK‐1). Curr Biol 8: 1366 – 1375 | en_US |
dc.identifier.citedreference | Edwards AS, Faux MC, Scott JD, Newton AC ( 1999 ) Carboxyl‐terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. J Biol Chem 274: 6461 – 6468 | en_US |
dc.identifier.citedreference | Etienne‐Manneville S, Hall A ( 2003 ) Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr Opin Cell Biol 15: 67 – 72 | en_US |
dc.identifier.citedreference | Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA ( 2006 ) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9: 341 – 349 | en_US |
dc.identifier.citedreference | Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM ( 2006 ) mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol 16: 1865 – 1870 | en_US |
dc.identifier.citedreference | Gao T, Newton AC ( 2002 ) The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem 277: 31585 – 31592 | en_US |
dc.identifier.citedreference | Griner EM, Kazanietz MG ( 2007 ) Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7: 281 – 294 | en_US |
dc.identifier.citedreference | Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM ( 2006 ) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt‐FOXO and PKCalpha, but not S6K1. Dev Cell 11: 859 – 871 | en_US |
dc.identifier.citedreference | Hauge C, Antal TL, Hirschberg D, Doehn U, Thorup K, Idrissova L, Hansen K, Jensen ON, Jorgensen TJ, Biondi RM, Frodin M ( 2007 ) Mechanism for activation of the growth factor‐activated AGC kinases by turn motif phosphorylation. EMBO J 26: 2251 – 2261 | en_US |
dc.identifier.citedreference | Hay N, Sonenberg N ( 2004 ) Upstream and downstream of mTOR. Genes Dev 18: 1926 – 1945 | en_US |
dc.identifier.citedreference | Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B ( 2006 ) SIN1/MIP1 maintains rictor‐mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125 – 137 | en_US |
dc.identifier.citedreference | Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y ( 2005 ) Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol 25: 7239 – 7248 | en_US |
dc.identifier.citedreference | Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM ( 2006 ) A pharmacological map of the PI3‐K family defines a role for p110alpha in insulin signaling. Cell 125: 733 – 747 | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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