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Crevicular fluid biomarkers and periodontal disease progression

dc.contributor.authorKinney, Janet S.en_US
dc.contributor.authorMorelli, Thiagoen_US
dc.contributor.authorOh, Minen_US
dc.contributor.authorBraun, Thomas M.en_US
dc.contributor.authorRamseier, Christoph A.en_US
dc.contributor.authorSugai, Jim V.en_US
dc.contributor.authorGiannobile, William V.en_US
dc.date.accessioned2014-02-11T17:57:17Z
dc.date.available2015-04-01T19:59:07Zen_US
dc.date.issued2014-02en_US
dc.identifier.citationKinney, Janet S.; Morelli, Thiago; Oh, Min; Braun, Thomas M.; Ramseier, Christoph A.; Sugai, Jim V.; Giannobile, William V. (2014). "Crevicular fluid biomarkers and periodontal disease progression." Journal of Clinical Periodontology 41(2): 113-120.en_US
dc.identifier.issn0303-6979en_US
dc.identifier.issn1600-051Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/102702
dc.description.abstractAim Assess the ability of a panel of gingival crevicular fluid ( GCF ) biomarkers as predictors of periodontal disease progression ( PDP ). Materials and methods In this study, 100 individuals participated in a 12‐month longitudinal investigation and were categorized into four groups according to their periodontal status. GCF , clinical parameters and saliva were collected bi‐monthly. Subgingival plaque and serum were collected bi‐annually. For 6 months, no periodontal treatment was provided. At 6 months, patients received periodontal therapy and continued participation from 6 to 12 months. GCF samples were analysed by ELISA for MMP ‐8, MMP ‐9, Osteoprotegerin, C‐reactive Protein and IL ‐1 β . Differences in median levels of GCF biomarkers were compared between stable and progressing participants using Wilcoxon Rank Sum test ( p  = 0.05). Clustering algorithm was used to evaluate the ability of oral biomarkers to classify patients as either stable or progressing. Results Eighty‐three individuals completed the 6‐month monitoring phase. With the exception of GCF C‐reactive protein, all biomarkers were significantly higher in the PDP group compared to stable patients. Clustering analysis showed highest sensitivity levels when biofilm pathogens and GCF biomarkers were combined with clinical measures, 74% (95% CI  = 61, 86). Conclusions Signature of GCF fluid‐derived biomarkers combined with pathogens and clinical measures provides a sensitive measure for discrimination of PDP (ClinicalTrials.gov NCT 00277745).en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherDisease Progressionen_US
dc.subject.otherLongitudinalen_US
dc.subject.otherBiomarkersen_US
dc.subject.otherGingival Crevicular Fluiden_US
dc.subject.otherPeriodontitisen_US
dc.titleCrevicular fluid biomarkers and periodontal disease progressionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102702/1/jcpe12194.pdf
dc.identifier.doi10.1111/jcpe.12194en_US
dc.identifier.sourceJournal of Clinical Periodontologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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