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Impact of a hormone‐releasing intrauterine system on the vaginal microbiome: a prospective baboon model
dc.contributor.authorHashway, S.A.en_US
dc.contributor.authorBergin, I.L.en_US
dc.contributor.authorBassis, C.M.en_US
dc.contributor.authorUchihashi, M.en_US
dc.contributor.authorSchmidt, K.C.en_US
dc.contributor.authorYoung, V.B.en_US
dc.contributor.authorAronoff, D.M.en_US
dc.contributor.authorPatton, D.L.en_US
dc.contributor.authorBell, J.D.en_US
dc.date.accessioned2014-05-21T18:02:34Z
dc.date.availableWITHHELD_13_MONTHSen_US
dc.date.available2014-05-21T18:02:34Z
dc.date.issued2014-04en_US
dc.identifier.citationHashway, S.A.; Bergin, I.L.; Bassis, C.M.; Uchihashi, M.; Schmidt, K.C.; Young, V.B.; Aronoff, D.M.; Patton, D.L.; Bell, J.D. (2014). "Impact of a hormone‐releasing intrauterine system on the vaginal microbiome: a prospective baboon model." Journal of Medical Primatology 43(2): 89-99.en_US
dc.identifier.issn0047-2565en_US
dc.identifier.issn1600-0684en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/106666
dc.description.abstractBackground Use of a levonorgestrel‐releasing intrauterine system ( LNG ‐ IUS ) in humans may alter vaginal microbial populations and susceptibility to pathogens. This study evaluated the time‐dependent effects of an LNG ‐ IUS on the vaginal microbiome of the baboon, a useful animal model for reproductive studies. Methods Levonorgestrel‐releasing intrauterine systems were inserted into three reproductively mature, female baboons. The animals were evaluated for 6 months by physical examination and G ram‐stained cytology. The vaginal microbiota was characterized at each timepoint by culture‐independent analysis of the 16 S rRNA ‐encoding gene. Results Each baboon harbored a diverse vaginal microbiome. Interindividual variation exceeded intra‐individual variation. Diversity declined over time in one baboon and showed mild fluctuations in the other two. There were no significant community differences from early to late post‐ LNG ‐ IUS placement. Conclusions The baboon vaginal microbiome is unique to each individual and is polymicrobial. In this pilot study, the vaginal microbiome remained stable from early to late post‐ LNG ‐ IUS placement.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.publisherDepartment of Microbiology & Immunology, University of Michigan Medical Schoolen_US
dc.subject.otherPyrosequencingen_US
dc.subject.otherNon‐Human Primateen_US
dc.subject.otherLevonorgestrelen_US
dc.titleImpact of a hormone‐releasing intrauterine system on the vaginal microbiome: a prospective baboon modelen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/106666/1/jmp12090.pdf
dc.identifier.doi10.1111/jmp.12090en_US
dc.identifier.sourceJournal of Medical Primatologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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