Biology of soft tissue wound healing and regeneration – Consensus Report of Group 1 of the 10th European Workshop on Periodontology
dc.contributor.author | Hämmerle, Christoph H. F. | en_US |
dc.contributor.author | Giannobile, William V. | en_US |
dc.date.accessioned | 2014-05-21T18:03:00Z | |
dc.date.available | WITHHELD_13_MONTHS | en_US |
dc.date.available | 2014-05-21T18:03:00Z | |
dc.date.issued | 2014-04 | en_US |
dc.identifier.citation | Hämmerle, Christoph H. F. ; Giannobile, William V. (2014). "Biology of soft tissue wound healing and regeneration â Consensus Report of Group 1 of the 10th European Workshop on Periodontology." Journal of Clinical Periodontology : S1-S5. | en_US |
dc.identifier.issn | 0303-6979 | en_US |
dc.identifier.issn | 1600-051X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/106721 | |
dc.description.abstract | Background The scope of this consensus was to review the biological processes of soft tissue wound healing in the oral cavity and to histologically evaluate soft tissue healing in clinical and pre‐clinical models. Aims To review the current knowledge regarding the biological processes of soft tissue wound healing at teeth, implants and on the edentulous ridge. Furthermore, to review soft tissue wound healing at these sites, when using barrier membranes, growth and differentiation factors and soft tissue substitutes. Collection of data Searches of the literature with respect to recessions at teeth and soft tissue deficiencies at implants, augmentation of the area of keratinized tissue and soft tissue volume were conducted. The available evidence was collected, categorized and summarized. Fundamental principles of oral soft tissue wound healing Oral mucosal and skin wound healing follow a similar pattern of the four phases of haemostasis, inflammation, proliferation and maturation/matrix remodelling. The soft connective tissue determines the characteristics of the overlaying oral epithelium. Within 7–14 days, epithelial healing of surgical wounds at teeth is completed. Soft tissue healing following surgery at implants requires 6–8 weeks for maturation. The resulting tissue resembles scar tissue. Well‐designed pre‐clinical studies providing histological data have been reported describing soft tissue wound healing, when using barrier membranes, growth and differentiation factors and soft tissue substitutes. Few controlled clinical studies with low numbers of patients are available for some of the treatments reviewed at teeth. Whereas, histological new attachment has been demonstrated in pre‐clinical studies resulting from some of the treatments reviewed, human histological data commonly report a lack of new attachment but rather long junctional epithelial attachment and connective tissue adhesion. Regarding soft tissue healing at implants human data are very scarce. Conclusions Oral soft tissue healing at teeth, implants and the edentulous ridge follows the same phases as skin wound healing. Histological studies in humans have not reported new attachment formation at teeth for the indications studied. Human histological data of soft tissue wound healing at implants are limited. Clinical recommendations The use of barriers membranes, growth and differentiation factors and soft tissue substitutes for the treatment of localized gingival/mucosal recessions, insufficient amount of keratinized tissue and insufficient soft tissue volume is at a developing stage. | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Periodontal/Peri‐Implant Wound Healing | en_US |
dc.subject.other | Scaffolds | en_US |
dc.subject.other | Soft Tissue Substitutes | en_US |
dc.subject.other | Human Histology | en_US |
dc.subject.other | Oral Soft Tissue | en_US |
dc.subject.other | Pre‐Clinical Studies | en_US |
dc.subject.other | Barrier Membranes | en_US |
dc.subject.other | Growth and Differentiation Factors | en_US |
dc.title | Biology of soft tissue wound healing and regeneration – Consensus Report of Group 1 of the 10th European Workshop on Periodontology | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/106721/1/jcpe12221.pdf | |
dc.identifier.doi | 10.1111/jcpe.12221 | en_US |
dc.identifier.source | Journal of Clinical Periodontology | en_US |
dc.identifier.citedreference | Vignoletti, F., Nunez, J. & Sanz, M. ( 2014 ) Soft tissue wound healing at teeth, dental implants and the edentulous ridge with scaffolds, cells and biologicals. Journal of Clinical Periodontology 41, accepted. | en_US |
dc.identifier.citedreference | Waerhaug, J. ( 1978 ) Healing of the dento‐epithelial junction following subgingival plaque control. I. As observed in human biopsy material. Journal of Periodontology 49, 1 – 8. doi: 10.1902/jop.1978.49.1.1. | en_US |
dc.identifier.citedreference | Berglundh, T., Abrahamsson, I., Welander, M., Lang, N. P. & Lindhe, J. ( 2007 ) Morphogenesis of the peri‐implant mucosa: an experimental study in dogs. Clinical Oral Implants Research 18, 1 – 8. doi: 10.1111/j.1600‐0501.2006.01380.x. | en_US |
dc.identifier.citedreference | Hiatt, W. H., Stallard, R. E., Butler, E. D. & Badgett, B. ( 1968 ) Repair following mucoperiosteal flap surgery with full gingival retention. Journal of Periodontology 39, 11 – 16. doi: 10.1902/jop.1968.39.1.11. | en_US |
dc.identifier.citedreference | Novaes, A. B., Kon, S., Ruben, M. P. & Goldman, H. M. ( 1969 ) Visualization of the microvascularization of the healing periodontal wound. 3. Gingivectomy. Journal of Periodontology 40, 359 – 371. doi: 10.1902/jop.1969.40.6.359. | en_US |
dc.identifier.citedreference | Schwarz, F., Mihatovic, I., Becker, J., Bormann, K. H., Keeve, P. L. & Friedmann, A. ( 2013 ) Histological evaluation of different abutments in the posterior maxilla and mandible: an experimental study in humans. Journal of Clinical Periodontology 40, 807 – 815. doi: 10.1111/jcpe.12115. | en_US |
dc.identifier.citedreference | Sculean, A., Gruber, R. & Bosshardt, D. D. ( 2014 ) Soft tissue wound healing around teeth and dental implants. Journal of Clinical Periodontology 41, accepted. | en_US |
dc.identifier.citedreference | Stahl, S. S., Weiner, J. M., Benjamin, S. & Yamada, L. ( 1971 ) Soft tissue healing following curettage and root planing. Journal of Periodontology 42, 678 – 684. doi: 10.1902/jop.1971.42.11.678. | en_US |
dc.identifier.citedreference | Tomasi, C., Tessarolo, F., Caola, I., Wennstrom, J., Nollo, G. & Berglundh, T. ( 2013 ) Morphogenesis of peri‐implant mucosa revisited: an experimental study in humans. Clinical Oral Implants Research [Epub ahead of print]. doi: 10.1111/clr.12223. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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