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Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion

dc.contributor.authorQin, Yanen_US
dc.contributor.authorLi, Ziruen_US
dc.contributor.authorWang, Zhigangen_US
dc.contributor.authorLi, Yinen_US
dc.contributor.authorZhao, Jingen_US
dc.contributor.authorMulholland, Michaelen_US
dc.contributor.authorZhang, Weizhenen_US
dc.date.accessioned2014-05-21T18:03:27Z
dc.date.availableWITHHELD_13_MONTHSen_US
dc.date.available2014-05-21T18:03:27Z
dc.date.issued2014-04en_US
dc.identifier.citationQin, Yan; Li, Ziru; Wang, Zhigang; Li, Yin; Zhao, Jing; Mulholland, Michael; Zhang, Weizhen (2014). "Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion." Liver International 34(4): 567-575.en_US
dc.identifier.issn1478-3223en_US
dc.identifier.issn1478-3231en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/106759
dc.description.abstractBackground & Aims Ghrelin, a gut hormone with pleiotropic effects, may act as a protective signal in parenchymal cells. We investigated the protective effects of ghrelin on hepatocytes after ischaemia/reperfusion (I/R). Methods Hepatic injury was assessed by measurement of plasma alanine aminotransferase ( ALT ) and lactate dehydrogenase ( LDH ), histological analysis, and TUNEL assay. Effects of exogenous ghrelin and ghrelin receptor gene deletion on I/R induced injury of liver were evaluated. Results Ischaemia/reperfusion induced a profound injury to hepatocytes. This was accompanied by elevations in plasma ALT and LDH . Pretreatment with ghrelin significantly reduced elevations in plasma ALT and LDH , and attenuated tissue damage induced by hepatic I/R in mice. Hepatic injury induced by I/R was more pronounced in ghrelin receptor gene null mice. Ghrelin administration blocked the up‐regulation of AMP ‐activated protein kinase ( AMPK ) activity induced by hepatic I/R. Conclusions This study demonstrates that ghrelin contributes to the cytoprotection during hepatic I/R.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherLiveren_US
dc.subject.otherGhrelinen_US
dc.subject.otherAMPKen_US
dc.subject.otherGhrelin Receptoren_US
dc.subject.otherGut Hormoneen_US
dc.subject.otherHIRIen_US
dc.titleGhrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/106759/1/liv12286.pdf
dc.identifier.doi10.1111/liv.12286en_US
dc.identifier.sourceLiver Internationalen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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