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Ventricular remodelling in rabbits with sustained high‐fat diet
dc.contributor.authorZarzoso, M.en_US
dc.contributor.authorMironov, S.en_US
dc.contributor.authorGuerrero‐serna, G.en_US
dc.contributor.authorWillis, B. Ciceroen_US
dc.contributor.authorPandit, S. V.en_US
dc.date.accessioned2014-05-23T15:59:44Z
dc.date.availableWITHHELD_13_MONTHSen_US
dc.date.available2014-05-23T15:59:44Z
dc.date.issued2014-05en_US
dc.identifier.citationZarzoso, M.; Mironov, S.; Guerrero‐serna, G. ; Willis, B. Cicero; Pandit, S. V. (2014). "Ventricular remodelling in rabbits with sustained highâ fat diet." Acta Physiologica 211(1): 36-47.en_US
dc.identifier.issn1748-1708en_US
dc.identifier.issn1748-1716en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/106944
dc.description.abstractAim Excess weight gain and obesity are one of the most serious health problems in the western societies. These conditions enhance risk of cardiac disease and have been linked with increased prevalence for cardiac arrhythmias and sudden death. Our goal was to study the ventricular remodelling occurring in rabbits fed with high‐fat diet ( HFD ) and its potential arrhythmogenic mechanisms. Methods We used 15 NZW rabbits that were randomly assigned to a control ( n  = 7) or HFD group ( n  = 8) for 18 weeks. In vivo studies included blood glucose, electrocardiographic, and echocardiographic measurements. Optical mapping was performed in Langendorff‐perfused isolated hearts. Results Body weight (3.69 ± 0.31 vs. 2.94 ± 0.18 kg, P  < 0.001) and blood glucose levels (230 ± 61 vs. 141 ± 14 mg dL −1 , P  < 0.05) were higher in the HFD group vs. controls. The rate‐corrected QT interval and its dispersion were increased in HFD rabbits vs. controls (169 ± 10 vs. 146 ± 13 ms and 37 ± 11 vs. 9 ± 2 ms, respectively; P  < 0.05). Echocardiographic analysis showed morphological and functional alterations in HFD rabbits indicative of left ventricle (LV) hypertrophy. Isolated heart studies revealed no changes in repolarization and propagation properties under conditions of normal extracellular K + , suggesting that extrinsic factors could underlie those electrocardiographic modifications. There were no differences in the dynamics of ventricular fibrillation (frequency, wave breaks) in the presence of isoproterenol. However, HFD rabbits showed a small reduction in action potential duration and an increased incidence of arrhythmias during hyperkalaemia. Conclusion High‐fat feeding during 18 weeks in rabbits induced a type II diabetes phenotype, LV hypertrophy, abnormalities in repolarization and susceptibility to arrhythmias during hyperkalaemia.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherHigh‐Fat Dieten_US
dc.subject.otherVentricle Structure and Electrophysiologyen_US
dc.titleVentricular remodelling in rabbits with sustained high‐fat dieten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/106944/1/apha12185.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/106944/2/apha12185-sup-0001-FigS1-S4TableS1-S3.pdf
dc.identifier.doi10.1111/apha.12185en_US
dc.identifier.sourceActa Physiologicaen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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