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μ ‐Opioid activation in the prefrontal cortex in migraine attacks – brief report I

dc.contributor.authorDaSilva, Alexandre F.en_US
dc.contributor.authorNascimento, Thiago D.en_US
dc.contributor.authorDosSantos, Marcos F.en_US
dc.contributor.authorLucas, Sarahen_US
dc.contributor.authorHolsbeeck, Hendriken_US
dc.contributor.authorDeBoer, Mistyen_US
dc.contributor.authorMaslowski, Ericen_US
dc.contributor.authorLove, Tiffanyen_US
dc.contributor.authorMartikainen, Ilkka K.en_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.contributor.authorSmith, Yolanda R.en_US
dc.contributor.authorZubieta, Jon‐karen_US
dc.date.accessioned2014-07-03T14:41:17Z
dc.date.availableWITHHELD_12_MONTHSen_US
dc.date.available2014-07-03T14:41:17Z
dc.date.issued2014-06en_US
dc.identifier.citationDaSilva, Alexandre F.; Nascimento, Thiago D.; DosSantos, Marcos F.; Lucas, Sarah; Holsbeeck, Hendrik; DeBoer, Misty; Maslowski, Eric; Love, Tiffany; Martikainen, Ilkka K.; Koeppe, Robert A.; Smith, Yolanda R.; Zubieta, Jon‐kar (2014). " μ â Opioid activation in the prefrontal cortex in migraine attacks â brief report I." Annals of Clinical and Translational Neurology 1(6): 439-444.en_US
dc.identifier.issn2328-9503en_US
dc.identifier.issn2328-9503en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/107492
dc.description.abstractWe evaluated in vivo the μ ‐opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using positron emission tomography with the selective μ ‐opioid receptor ( μ OR ) radiotracer [11C]carfentanil. In the ictal phase, there was μ OR activation in the medial prefrontal cortex, which was strongly associated with the μ OR availability level during the interictal phase. Furthermore, μ ‐opioid binding changes showed moderate negative correlation with the combined extension and severity of the attacks. These results indicate for the first time that there is high μ OR activation in the migraineurs' brains during headache attacks in response to their pain.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.titleμ ‐Opioid activation in the prefrontal cortex in migraine attacks – brief report Ien_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurology and Neurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/107492/1/acn365.pdf
dc.identifier.doi10.1002/acn3.65en_US
dc.identifier.sourceAnnals of Clinical and Translational Neurologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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