Clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes
dc.contributor.author | Tatarakis, Nikolaos | en_US |
dc.contributor.author | Kinney, Janet S. | en_US |
dc.contributor.author | Inglehart, Marita | en_US |
dc.contributor.author | Braun, Thomas M. | en_US |
dc.contributor.author | Shelburne, Charles | en_US |
dc.contributor.author | Lang, Niklaus P. | en_US |
dc.contributor.author | Giannobile, William V. | en_US |
dc.contributor.author | Oh, Tae‐ju | en_US |
dc.date.accessioned | 2014-07-03T14:41:19Z | |
dc.date.available | WITHHELD_13_MONTHS | en_US |
dc.date.available | 2014-07-03T14:41:19Z | |
dc.date.issued | 2014-07 | en_US |
dc.identifier.citation | Tatarakis, Nikolaos; Kinney, Janet S.; Inglehart, Marita; Braun, Thomas M.; Shelburne, Charles; Lang, Niklaus P.; Giannobile, William V.; Oh, Tae‐ju (2014). "Clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes." Clinical Oral Implants Research 25(7): 803-812. | en_US |
dc.identifier.issn | 0905-7161 | en_US |
dc.identifier.issn | 1600-0501 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/107497 | |
dc.description.abstract | Objective Regulators of peri‐implant bone loss in patients with diabetes appear to involve multiple risk factors that have not been clearly elucidated. This study was conducted to explore putative local etiologic factors on implant bone loss in relation to type 2 diabetes mellitus, including clinical, microbial, salivary biomarker, and psychosocial factors. Materials and methods Thirty‐two subjects (divided into type 2 diabetes mellitus and non‐diabetic controls), having at least one functional implant and six teeth, were enrolled in a 1‐year longitudinal investigation. Analyses of clinical measurements and standardized intra‐oral radiographs, saliva and serum biomarkers (via protein arrays for 20 selected markers), and plaque biofilm (via q PCR for eight periodontal pathogens) were performed at baseline and 1 year. In addition, the subjects were asked to respond to questionnaires to assess behavioral and psychosocial variables. Results There was a significant increase from baseline to 1 year in the probing depth of implants in the diabetes group (1.95 mm to 2.35 mm, P = 0.015). The average radiographic bone loss during the study period marginally increased at dental implants compared to natural teeth over the study period (0.08 mm vs. 0.05 mm; P = 0.043). The control group harbored higher levels of T reponema denticola at their teeth at baseline ( P = 0.046), and the levels of the pathogen increased significantly over time around the implants of the same group ( P = 0.003). Salivary osteoprotegerin ( OPG ) levels were higher in the diabetes group than the control group at baseline only; in addition, the salivary levels of IL ‐4, IL ‐10, and OPG associated with host defense were significantly reduced in the diabetes group ( P = 0.010, P = 0.019, and P = 0.024), while controls showed an increase in the salivary OPG levels ( P = 0.005). For psychosocial factors, there were not many significant changes over the observation period, except for some findings related to coping behaviors at baseline. Conclusions The study suggests that the clinical, microbiological, salivary biomarker, and psychosocial profiles of dental implant patients with type 2 diabetes who are under good metabolic control and regular maintenance care are very similar to those of non‐diabetic individuals. Future studies are warranted to validate the findings in longer‐term and larger clinical trials ( ClinicalTrials.gov # NCT00933491). | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.publisher | Sage | en_US |
dc.subject.other | Salivary Diagnostics | en_US |
dc.subject.other | Alveolar Bone Loss | en_US |
dc.subject.other | Dental Implants | en_US |
dc.subject.other | Diabetes Mellitus | en_US |
dc.subject.other | Microbiology | en_US |
dc.subject.other | Psychosocial Indicator | en_US |
dc.title | Clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/107497/1/clr12139.pdf | |
dc.identifier.doi | 10.1111/clr.12139 | en_US |
dc.identifier.source | Clinical Oral Implants Research | en_US |
dc.identifier.citedreference | Paulander, J., Axelsson, P., Lindhe, J. & Wennstrom, J. ( 2004 ) Intra‐oral pattern of tooth and periodontal bone loss between the age of 50 and 60 years. A longitudinal prospective study. Acta Odontologica Scandinavica 62: 214 – 222. | en_US |
dc.identifier.citedreference | Mealey, B.L. & Oates, T.W. ( 2006 ) Diabetes mellitus and periodontal diseases. Journal of Periodontology 77: 1289 – 1303. | en_US |
dc.identifier.citedreference | Mullally, B.H., Dace, B., Shelburne, C.E., Wolff, L.F. & Coulter, W.A. ( 2000 ) Prevalence of periodontal pathogens in localized and generalized forms of early‐onset periodontitis. Journal of periodontal research 35: 232 – 241. | en_US |
dc.identifier.citedreference | Nelson, R.G., Shlossman, M., Budding, L.M., Pettitt, D.J., Saad, M.F., Genco, R.J. & Knowler, W.C. ( 1990 ) Periodontal disease and NIDDM in Pima Indians. Diabetes Care 13: 836 – 840. | en_US |
dc.identifier.citedreference | Norderyd, O., Hugoson, A. & Grusovin, G. ( 1999 ) Risk of severe periodontal disease in a swedish adult population. A longitudinal study. Journal of Clinical Periodontology 26: 608 – 615. | en_US |
dc.identifier.citedreference | Novaes, A.B., Jr, Gutierrez, F.G. & Novaes, A.B. ( 1996 ) Periodontal disease progression in type II non‐insulin‐dependent diabetes mellitus patients (NIDDM). Part I – probing pocket depth and clinical attachment. Brazilian Dental Journal 7: 65 – 73. | en_US |
dc.identifier.citedreference | Offenbacher, S., Barros, S.P. & Beck, J.D. ( 2008 ) Rethinking periodontal inflammation. Journal of Periodontology 79: 1577 – 1584. | en_US |
dc.identifier.citedreference | Oringer, R.J., Palys, M.D., Iranmanesh, A., Fiorellini, J.P., Haffajee, A.D., Socransky, S.S. & Giannobile, W.V. ( 1998 ) C‐telopeptide cross‐links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clinical oral implants research 9: 365 – 373. | en_US |
dc.identifier.citedreference | Osborn, C.Y., Patel, K.A., Liu, J., Trott, H.W., Buchowski, M.S., Hargreaves, M.K., Blot, W.J., Cohen, S.S. & Schlundt, D.G. ( 2011 ) Diabetes and co‐morbid depression among racially diverse, low‐income adults. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine 41: 300 – 309. | en_US |
dc.identifier.citedreference | O'Sullivan, E.P., Ashley, D.T., Davenport, C., Devlin, N., Crowley, R., Agha, A., Thompson, C.J., O'Gorman, D. & Smith, D. ( 2010 ) Osteoprotegerin and biomarkers of vascular inflammation in type 2 diabetes. Diabetes/Metabolism Research and Reviews 26: 496 – 502. | en_US |
dc.identifier.citedreference | Page, R.C., Krall, E.A., Martin, J., Mancl, L. & Garcia, R.I. ( 2002 ) Validity and accuracy of a risk calculator in predicting periodontal disease. Journal of the American Dental Association 133: 569 – 576. | en_US |
dc.identifier.citedreference | Peruzzo, D.C., Benatti, B.B., Ambrosano, G.M., Nogueira‐Filho, G.R., Sallum, E.A., Casati, M.Z. & Nociti, F.H., Jr. ( 2007 ) A systematic review of stress and psychological factors as possible risk factors for periodontal disease. Journal of Periodontology 78: 1491 – 1504. | en_US |
dc.identifier.citedreference | Pjetursson, B.E., Bragger, U., Lang, N.P. & Zwahlen, M. ( 2007 ) Comparison of survival and complication rates of tooth‐supported fixed dental prostheses (FDPs) and implant‐supported FDPS and single crowns (SCs). Clinical Oral Implants Research 18 ( Suppl 3 ): 97 – 113. | en_US |
dc.identifier.citedreference | Radloff, L.S. ( 1977 ) The CES‐D scale: a self‐report depression scale for research in the general population. Applied Psychological Measurement 1: 385 – 401. | en_US |
dc.identifier.citedreference | Ramseier, C.A., Kinney, J.S., Herr, A.E., Braun, T., Sugai, J.V., Shelburne, C.A., Rayburn, L.A., Tran, H.M., Singh, A.K. & Giannobile, W.V. ( 2009 ) Identification of pathogen and host‐response markers correlated with periodontal disease. Journal of Periodontology 80: 436 – 446. | en_US |
dc.identifier.citedreference | Schatzle, M., Loe, H., Lang, N.P., Heitz‐Mayfield, L.J., Burgin, W., Anerud, A. & Boysen, H. ( 2003 ) Clinical course of chronic periodontitis. III. Patterns, variations and risks of attachment loss. Journal of Clinical Periodontology 30: 909 – 918. | en_US |
dc.identifier.citedreference | Schoppet, M., Sattler, A.M., Schaefer, J.R., Herzum, M., Maisch, B. & Hofbauer, L.C. ( 2003 ) Increased osteoprotegerin serum levels in men with coronary artery disease. The Journal of Clinical Endocrinology and Metabolism 88: 1024 – 1028. | en_US |
dc.identifier.citedreference | Soskolne, W.A. & Klinger, A. ( 2001 ) The relationship between periodontal diseases and diabetes: an overview. Annals of Periodontology 6: 91 – 98. | en_US |
dc.identifier.citedreference | Taba, M. Jr, Kinney, J., Kim, A.S. & Giannobile, W.V. ( 2005 ) Diagnostic biomarkers for oral and periodontal diseases. Dental Clinics of North America 49: 551 – 571, vi. | en_US |
dc.identifier.citedreference | Tawil, G., Younan, R., Azar, P. & Sleilati, G. ( 2008 ) Conventional and advanced implant treatment in the type ii diabetic patient: surgical protocol and long‐term clinical results. The International Journal of Oral & Maxillofacial Implants 23: 744 – 752. | en_US |
dc.identifier.citedreference | Taylor, G.W. ( 2001 ) Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Annals of Periodontology 6: 99 – 112. | en_US |
dc.identifier.citedreference | Taylor, G.W. & Borgnakke, W.S. ( 2008 ) Periodontal disease: associations with diabetes, glycemic control and complications. Oral Diseases 14: 191 – 203. | en_US |
dc.identifier.citedreference | Taylor, G.W., Burt, B.A., Becker, M.P., Genco, R.J., Shlossman, M., Knowler, W.C. & Pettitt, D.J. ( 1998 ) Non‐insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years. Journal of periodontology 69: 76 – 83. | en_US |
dc.identifier.citedreference | Tomasi, C., Wennstrom, J.L. & Berglundh, T. ( 2008 ) Longevity of teeth and implants – a systematic review. Journal of Oral Rehabilitation 35 ( Suppl 1 ): 23 – 32. | en_US |
dc.identifier.citedreference | Tuncay, T., Musabak, I., Gok, D.E. & Kutlu, M. ( 2008 ) The relationship between anxiety, coping strategies and characteristics of patients with diabetes. Health and Quality of Life Outcomes 6: 79. | en_US |
dc.identifier.citedreference | US Department of Health and Human Services, C. f. D. C. a. P. ( 2011 ) Centers for disease control and prevention. National diabetes fact sheet: National estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA. | en_US |
dc.identifier.citedreference | Wild, S., Roglic, G., Green, A., Sicree, R. & King, H. ( 2004 ) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047 – 1053. | en_US |
dc.identifier.citedreference | van Winkelhoff, A.J., Goene, R.J., Benschop, C. & Folmer, T. ( 2000 ) Early colonization of dental implants by putative periodontal pathogens in partially edentulous patients. Clinical oral implants research 11: 511 – 520. | en_US |
dc.identifier.citedreference | Yuan, K., Chang, C.J., Hsu, P.C., Sun, H.S., Tseng, C.C. & Wang, J.R. ( 2001 ) Detection of putative periodontal pathogens in non‐insulin‐dependent diabetes mellitus and non‐diabetes mellitus by polymerase chain reaction. Journal of Periodontal Research 36: 18 – 24. | en_US |
dc.identifier.citedreference | Ali, S., Stone, M.A., Peters, J.L., Davies, M.J. & Khunti, K. ( 2006 ) The prevalence of co‐morbid depression in adults with type 2 diabetes: a systematic review and meta‐analysis. Diabetic Medicine: A Journal of the British Diabetic Association 23: 1165 – 1173. | en_US |
dc.identifier.citedreference | Association, A.D. ( 2011 ) Standards of medical care in diabetes–2011. Diabetes Care 34 ( Suppl 1 ): S11 – S61. | en_US |
dc.identifier.citedreference | Berglundh, T., Persson, L. & Klinge, B. ( 2002 ) A systematic review of the incidence of biological and technical complications in implant dentistry reported in prospective longitudinal studies of at least 5 years. Journal of clinical periodontology 29 ( Suppl. 3 ): 197 – 212; discussion 232–193. | en_US |
dc.identifier.citedreference | Carver, C.S. ( 1997 ) You want to measure coping but your protocol's too long: consider the brief cope. International Journal of Behavioral Medicine 4: 92 – 100. | en_US |
dc.identifier.citedreference | Cohen, S. & Williamson, G. ( 1988 ) Perceived stress in a probability sample of the United States. In: Spacapan, S. & Oskamp, S., eds. The Social Psychology of Health, 31 – 67. Newbury Park, CA: Sage. | en_US |
dc.identifier.citedreference | Collin, H.L., Uusitupa, M., Niskanen, L., Kontturi‐Narhi, V., Markkanen, H., Koivisto, A.M. & Meurman, J.H. ( 1998 ) Periodontal findings in elderly patients with non‐insulin dependent diabetes mellitus. Journal of periodontology 69: 962 – 966. | en_US |
dc.identifier.citedreference | Costa, F.O., Takenaka‐Martinez, S., Cota, L.O., Ferreira, S.D., Silva, G.L. & Costa, J.E. ( 2012 ) Peri‐implant disease in subjects with and without preventive maintenance: a 5‐year follow‐up. Journal of clinical periodontology 39: 173 – 181. | en_US |
dc.identifier.citedreference | Costa, P.P., Trevisan, G.L., Macedo, G.O., Palioto, D.B., Souza, S.L., Grisi, M.F., Novaes, A.B., Jr & Taba, M., Jr. ( 2010 ) Salivary interleukin‐6, matrix metalloproteinase‐8, and osteoprotegerin in patients with periodontitis and diabetes. Journal of periodontology 81: 384 – 391. | en_US |
dc.identifier.citedreference | Duckworth, J.E., Judy, P.F., Goodson, J.M. & Socransky, S.S. ( 1983 ) A method for the geometric and densitometric standardization of intraoral radiographs. Journal of Periodontology 54: 435 – 440. | en_US |
dc.identifier.citedreference | Genco, R.J. ( 1996 ) Current view of risk factors for periodontal diseases. Journal of Periodontology 67: 1041 – 1049. | en_US |
dc.identifier.citedreference | Haffajee, A.D., Socransky, S.S. & Goodson, J.M. ( 1983 ) Comparison of different data analyses for detecting changes in attachment level. Journal of Clinical Periodontology 10: 298 – 310. | en_US |
dc.identifier.citedreference | Heitz‐Mayfield, L.J. ( 2008 ) Peri‐implant diseases: diagnosis and risk indicators. Journal of Clinical Periodontology 35: 292 – 304. | en_US |
dc.identifier.citedreference | Ismail, A.I., Morrison, E.C., Burt, B.A., Caffesse, R.G. & Kavanagh, M.T. ( 1990 ) Natural history of periodontal disease in adults: findings from the Tecumseh periodontal disease study, 1959–87. Journal of Dental Research 69: 430 – 435. | en_US |
dc.identifier.citedreference | Jung, R.E., Pjetursson, B.E., Glauser, R., Zembic, A., Zwahlen, M. & Lang, N.P. ( 2008 ) A systematic review of the 5‐year survival and complication rates of implant‐supported single crowns. Clinical Oral Implants Research 19: 119 – 130. | en_US |
dc.identifier.citedreference | Kinney, J.S., Morelli, T., Braun, T., Ramseier, C.A., Herr, A.E., Sugai, J.V., Shelburne, C.E., Rayburn, L.A., Singh, A.K. & Giannobile, W.V. ( 2011 ) Saliva/pathogen biomarker signatures and periodontal disease progression. Journal of Dental Research 90: 752 – 758. | en_US |
dc.identifier.citedreference | Kornman, K.S. ( 2008 ) Mapping the pathogenesis of periodontitis: a new look. Journal of Periodontology 79: 1560 – 1568. | en_US |
dc.identifier.citedreference | Laine, M.L., Moustakis, V., Koumakis, L., Potamias, G. & Loos, B. ( 2013 ) Modeling susceptibility to periodontitis. Journal of Dental Research 92: 45 – 50. | en_US |
dc.identifier.citedreference | Lamster, I.B., Smith, Q.T., Celenti, R.S., Singer, R.E. & Grbic, J.T. ( 1994 ) Development of a risk profile for periodontal disease: microbial and host response factors. Journal of Periodontology 65: 511 – 520. | en_US |
dc.identifier.citedreference | Lang, N.P. & Tonetti, M.S. ( 2003 ) Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT). Oral Health & Preventive Dentistry 1: 7 – 16. | en_US |
dc.identifier.citedreference | Lavstedt, S., Bolin, A. & Henrikson, C.O. ( 1986 ) Proximal alveolar bone loss in a longitudinal radiographic investigation. II. A 10‐year follow‐up study of an epidemiologic material. Acta Odontologica Scandinavica 44: 199 – 205. | en_US |
dc.identifier.citedreference | Leonhardt, A., Adolfsson, B., Lekholm, U., Wikstrom, M. & Dahlen, G. ( 1993 ) A longitudinal microbiological study on osseointegrated titanium implants in partially edentulous patients. Clinical Oral Implants Research 4: 113 – 120. | en_US |
dc.identifier.citedreference | Lindhe, J. & Meyle, J. ( 2008 ) Peri‐implant diseases: consensus report of the sixth European workshop on periodontology. Journal of Clinical Periodontology 35: 282 – 285. | en_US |
dc.identifier.citedreference | Loe, H. ( 1993 ) Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 16: 329 – 334. | en_US |
dc.identifier.citedreference | Mandel, I.D. & Wotman, S. ( 1976 ) The salivary secretions in health and disease. Oral Sciences Reviews 8: 25 – 47. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.