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Osteocytes Serve as a Progenitor Cell of Osteosarcoma
dc.contributor.authorSottnik, Joseph L.en_US
dc.contributor.authorCampbell, Brittanyen_US
dc.contributor.authorMehra, Rohiten_US
dc.contributor.authorBehbahani‐nejad, Omiden_US
dc.contributor.authorHall, Christopher L.en_US
dc.contributor.authorKeller, Evan T.en_US
dc.date.accessioned2014-07-03T14:41:37Z
dc.date.availableWITHHELD_14_MONTHSen_US
dc.date.available2014-07-03T14:41:37Z
dc.date.issued2014-08en_US
dc.identifier.citationSottnik, Joseph L.; Campbell, Brittany; Mehra, Rohit; Behbahani‐nejad, Omid ; Hall, Christopher L.; Keller, Evan T. (2014). "Osteocytes Serve as a Progenitor Cell of Osteosarcoma." Journal of Cellular Biochemistry 115(8): 1420-1429.en_US
dc.identifier.issn0730-2312en_US
dc.identifier.issn1097-4644en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/107570
dc.description.abstractOsteosarcoma (OSA) is the most common primary bone tumor in humans. However, the cell of origin of OSA is not clearly defined although there is evidence that osteoblasts may serve as OSA progenitors. The role of osteocytes, terminally differentiated osteoblasts, as OSA progenitors has yet to be described. Analysis of patient cDNA from publicly available microarray data revealed that patients with OSA have increased expression of dentin matrix phosphoprotein 1 (DMP1), a marker of osteocytes. Analysis of multiple murine, human, and canine OSA cell lines revealed DMP1 expression. To test the tumorigenic potential of osteocytes, MLO‐Y4, a SV‐40 immortalized murine osteocyte cell line, was injected into subcutaneous and orthotopic (intratibial) sites of mice. Tumor growth occurred in both locations. Orthotopic MLO‐Y4 tumors produced mixed osteoblastic/osteolytic radiographic lesions; a hallmark of OSA. Together, these data demonstrate for the first time that osteocytes can serve as OSA progenitors. J. Cell. Biochem. 115: 1420–1429, 2014. © 2014 Wiley Periodicals, Inc.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherDMP1en_US
dc.subject.otherBONEen_US
dc.subject.otherOSTEOCYTEen_US
dc.subject.otherOSTEOSARCOMAen_US
dc.subject.otherCANCERen_US
dc.titleOsteocytes Serve as a Progenitor Cell of Osteosarcomaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/107570/1/jcb24793.pdf
dc.identifier.doi10.1002/jcb.24793en_US
dc.identifier.sourceJournal of Cellular Biochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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