μ ‐Opioid activation in the midbrain during migraine allodynia – brief report II
dc.contributor.author | Nascimento, Thiago D. | en_US |
dc.contributor.author | DosSantos, Marcos F. | en_US |
dc.contributor.author | Lucas, Sarah | en_US |
dc.contributor.author | Holsbeeck, Hendrik | en_US |
dc.contributor.author | DeBoer, Misty | en_US |
dc.contributor.author | Maslowski, Eric | en_US |
dc.contributor.author | Love, Tiffany | en_US |
dc.contributor.author | Martikainen, Ilkka K. | en_US |
dc.contributor.author | Koeppe, Robert A. | en_US |
dc.contributor.author | Smith, Yolanda R. | en_US |
dc.contributor.author | Zubieta, Jon‐kar | en_US |
dc.contributor.author | DaSilva, Alexandre F. | en_US |
dc.date.accessioned | 2014-07-03T14:41:41Z | |
dc.date.available | WITHHELD_12_MONTHS | en_US |
dc.date.available | 2014-07-03T14:41:41Z | |
dc.date.issued | 2014-06 | en_US |
dc.identifier.citation | Nascimento, Thiago D.; DosSantos, Marcos F.; Lucas, Sarah; Holsbeeck, Hendrik; DeBoer, Misty; Maslowski, Eric; Love, Tiffany; Martikainen, Ilkka K.; Koeppe, Robert A.; Smith, Yolanda R.; Zubieta, Jon‐kar ; DaSilva, Alexandre F. (2014). " μ â Opioid activation in the midbrain during migraine allodynia â brief report II." Annals of Clinical and Translational Neurology 1(6): 445-450. | en_US |
dc.identifier.issn | 2328-9503 | en_US |
dc.identifier.issn | 2328-9503 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/107586 | |
dc.description.abstract | We investigated in vivo the allodynic response of the central μ ‐opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography ( PET ) with the selective μ ‐opioid receptor ( μ OR ) radiotracer [11C]carfentanil. Females were scanned during the mid‐late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μ OR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μ OR activation in the migraineurs' brains in response to their allodynic experience. | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.title | μ ‐Opioid activation in the midbrain during migraine allodynia – brief report II | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurology and Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/107586/1/acn366.pdf | |
dc.identifier.doi | 10.1002/acn3.66 | en_US |
dc.identifier.source | Annals of Clinical and Translational Neurology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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