View Item 

Show simple item record

μ ‐Opioid activation in the midbrain during migraine allodynia – brief report II
dc.contributor.authorNascimento, Thiago D.en_US
dc.contributor.authorDosSantos, Marcos F.en_US
dc.contributor.authorLucas, Sarahen_US
dc.contributor.authorHolsbeeck, Hendriken_US
dc.contributor.authorDeBoer, Mistyen_US
dc.contributor.authorMaslowski, Ericen_US
dc.contributor.authorLove, Tiffanyen_US
dc.contributor.authorMartikainen, Ilkka K.en_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.contributor.authorSmith, Yolanda R.en_US
dc.contributor.authorZubieta, Jon‐karen_US
dc.contributor.authorDaSilva, Alexandre F.en_US
dc.date.accessioned2014-07-03T14:41:41Z
dc.date.availableWITHHELD_12_MONTHSen_US
dc.date.available2014-07-03T14:41:41Z
dc.date.issued2014-06en_US
dc.identifier.citationNascimento, Thiago D.; DosSantos, Marcos F.; Lucas, Sarah; Holsbeeck, Hendrik; DeBoer, Misty; Maslowski, Eric; Love, Tiffany; Martikainen, Ilkka K.; Koeppe, Robert A.; Smith, Yolanda R.; Zubieta, Jon‐kar ; DaSilva, Alexandre F. (2014). " μ â Opioid activation in the midbrain during migraine allodynia â brief report II." Annals of Clinical and Translational Neurology 1(6): 445-450.en_US
dc.identifier.issn2328-9503en_US
dc.identifier.issn2328-9503en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/107586
dc.description.abstractWe investigated in vivo the allodynic response of the central μ ‐opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography ( PET ) with the selective μ ‐opioid receptor ( μ OR ) radiotracer [11C]carfentanil. Females were scanned during the mid‐late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μ OR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μ OR activation in the migraineurs' brains in response to their allodynic experience.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.titleμ ‐Opioid activation in the midbrain during migraine allodynia – brief report IIen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurology and Neurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/107586/1/acn366.pdf
dc.identifier.doi10.1002/acn3.66en_US
dc.identifier.sourceAnnals of Clinical and Translational Neurologyen_US
dc.identifier.citedreferenceDaSilva AF, Nascimento TD, Dos Santos M, et al. μ‐Opioid activation in the prefrontal cortex in migraine attacks – brief report I. Ann Clin Transl Neurol 2014; doi: 10.1002/acn3.65 [Epub ahead of print].en_US
dc.identifier.citedreferenceThe International Classification of Headache Disorders, 3 rd edition (beta version). Cephalalgia 2013; 33: 629 – 808.en_US
dc.identifier.citedreferenceBurgess SE, Gardell LR, Ossipov MH, et al. Time‐dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 2002; 22: 5129 – 5136.en_US
dc.identifier.citedreferenceDe Felice M, Porreca F. Opiate‐induced persistent pronociceptive trigeminal neural adaptations: potential relevance to opiate‐induced medication overuse headache. Cephalalgia 2009; 29: 1277 – 1284.en_US
dc.identifier.citedreferenceLandy S, Rice K, Lobo B. Central sensitisation and cutaneous allodynia in migraine: implications for treatment. CNS Drugs 2004; 18: 337 – 342.en_US
dc.identifier.citedreferenceWilliamson DJ, Shepheard SL, Cook DA, et al. Role of opioid receptors in neurogenic dural vasodilation and sensitization of trigeminal neurones in anaesthetized rats. Br J Pharmacol 2001; 133: 807 – 814.en_US
dc.identifier.citedreferenceStankewitz A, Aderjan D, Eippert F, May A. Trigeminal nociceptive transmission in migraineurs predicts migraine attacks. J Neurosci 2011; 31: 1937 – 1943.en_US
dc.identifier.citedreferenceWager TD, Scott DJ, Zubieta JK. Placebo effects on human mu‐opioid activity during pain. Proc Natl Acad Sci USA 2007; 104: 11056 – 11061.en_US
dc.identifier.citedreferenceKnight YE, Goadsby PJ. The periaqueductal grey matter modulates trigeminovascular input: a role in migraine? Neuroscience 2001; 106: 793 – 800.en_US
dc.identifier.citedreferenceZubieta JK, Smith YR, Bueller JA, et al. mu‐opioid receptor‐mediated antinociceptive responses differ in men and women. J Neurosci 2002; 22: 5100 – 5107.en_US
dc.identifier.citedreferenceZubieta JK, Smith YR, Bueller JA, et al. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 2001; 293: 311 – 315.en_US
dc.identifier.citedreferenceMeyer CR, Boes JL, Kim B, et al. Demonstration of accuracy and clinical versatility of mutual information for automatic multimodality image fusion using affine and thin‐plate spline warped geometric deformations. Med Image Anal 1997; 1: 195 – 206.en_US
dc.identifier.citedreferenceJewett DM. A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC. Nucl Med Biol 2001; 28: 733 – 734.en_US
dc.identifier.citedreferenceTiteler M, Lyon RA, Kuhar MJ, et al. Mu opiate receptors are selectively labelled by [3H]carfentanil in human and rat brain. Eur J Pharmacol 1989; 167: 221 – 228.en_US
dc.identifier.citedreferenceLipton RB, Bigal ME. Opioid therapy and headache: a cause and a cure. Neurology 2004; 62: 1662 – 1663.en_US
dc.identifier.citedreferenceDe Felice M, Ossipov MH, Porreca F. Update on medication‐overuse headache. Curr Pain Headache Rep 2011; 15: 79 – 83.en_US
dc.identifier.citedreferenceWelch K. Pitfalls for readers of “special issue on pearls and pitfalls in headache research”. Cephalalgia 2014; 34: 237.en_US
dc.identifier.citedreferenceWang Z, Zeng XY, Han SP, et al. Interleukin‐10 of red nucleus plays anti‐allodynia effect in neuropathic pain rats with spared nerve injury. Neurochem Res 2012; 37: 9.en_US
dc.identifier.citedreferenceZhang Q, Wang J, Duan MT, et al. NF‐kappaB, ERK, p38 MAPK and JNK contribute to the initiation and/or maintenance of mechanical allodynia induced by tumor necrosis factor‐alpha in the red nucleus. Brain Res Bull 2013; 99: 132 – 139.en_US
dc.identifier.citedreferenceNioche C, Cabanis EA, Habas C. Functional connectivity of the human red nucleus in the brain resting state at 3T. AJNR Am J Neuroradiol 2009; 30: 396 – 403.en_US
dc.identifier.citedreferenceLogan J, Fowler JS, Volkow ND, et al. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 1996; 16: 834 – 840.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
acn366.pdf
Size:
308.1KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.