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Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy
dc.contributor.authorDemiroz, Candanen_US
dc.contributor.authorVainshtein, Jeffrey M.en_US
dc.contributor.authorKoukourakis, Georgios V.en_US
dc.contributor.authorGutfeld, Oriten_US
dc.contributor.authorPrince, Mark E.en_US
dc.contributor.authorBradford, Carol R.en_US
dc.contributor.authorWolf, Gregory T.en_US
dc.contributor.authorMcLean, Scotten_US
dc.contributor.authorWorden, Francis P.en_US
dc.contributor.authorChepeha, Douglas B.en_US
dc.contributor.authorSchipper, Matthew J.en_US
dc.contributor.authorMcHugh, Jonathan B.en_US
dc.contributor.authorEisbruch, Avrahamen_US
dc.date.accessioned2014-11-04T16:35:35Z
dc.date.availableWITHHELD_13_MONTHSen_US
dc.date.available2014-11-04T16:35:35Z
dc.date.issued2014-11en_US
dc.identifier.citationDemiroz, Candan; Vainshtein, Jeffrey M.; Koukourakis, Georgios V.; Gutfeld, Orit; Prince, Mark E.; Bradford, Carol R.; Wolf, Gregory T.; McLean, Scott; Worden, Francis P.; Chepeha, Douglas B.; Schipper, Matthew J.; McHugh, Jonathan B.; Eisbruch, Avraham (2014). "Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy." Head & Neck 36(11): 1589-1595.en_US
dc.identifier.issn1043-3074en_US
dc.identifier.issn1097-0347en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/109313
dc.description.abstractBackground Management of head and neck carcinoma from unknown primary (HNCUP) remains controversial, with neck dissection and radiotherapy (RT) or definitive RT both commonly used. The purpose of this study was to characterize HNCUP and retrospectively compare outcomes for patients treated with neck dissection + RT versus definitive RT. Methods From 1994 to 2009, 41 patients with HNCUP underwent either neck dissection + RT ( n  = 22) or definitive RT ± concurrent chemotherapy ( n  = 19) at our institution. Treatment outcomes were compared using Kaplan–Meier methods and log‐rank test. Results There were no differences between patients treated with neck dissection + RT and definitive RT in overall survival (OS), progression‐free survival (PFS), locoregional relapse‐free survival (LRFS), freedom from locoregional failure (FFLRG), or freedom from distant failure (FFDF). Among 17 patients who underwent neck dissection + RT for whom human papillomavirus (HPV) status could be determined, HPV(+) patients trended toward improved OS ( p  = .06) and PFS ( p  = .15). Conclusion Neck dissection and postoperative RT resulted in similar outcomes as definitive RT. The prognostic implications of HPV(+) nodes in HNCUP are similar to those in oropharyngeal primary cancers. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1589–1595, 2014en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherUnknown Primaryen_US
dc.subject.otherNeck Dissectionen_US
dc.subject.otherRadiation Therapyen_US
dc.subject.otherHuman Papillomavirusen_US
dc.titleHead and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/109313/1/hed23479.pdf
dc.identifier.doi10.1002/hed.23479en_US
dc.identifier.sourceHead & Necken_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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