Dietary acid load and chronic kidney disease among adults in the United States
dc.contributor.author | Banerjee, Tanushree | |
dc.contributor.author | Crews, Deidra C | |
dc.contributor.author | Wesson, Donald E | |
dc.contributor.author | Tilea, Anca | |
dc.contributor.author | Saran, Rajiv | |
dc.contributor.author | Rios Burrows, Nilka | |
dc.contributor.author | Williams, Desmond E | |
dc.contributor.author | Powe, Neil R | |
dc.date.accessioned | 2014-12-08T17:45:14Z | |
dc.date.available | 2014-12-08T17:45:14Z | |
dc.date.issued | 2014-08-24 | |
dc.identifier.citation | BMC Nephrology. 2014 Aug 24;15(1):137 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/109474 | en_US |
dc.description.abstract | Abstract Background Diet can markedly affect acid-base status and it significantly influences chronic kidney disease (CKD) and its progression. The relationship of dietary acid load (DAL) and CKD has not been assessed on a population level. We examined the association of estimated net acid excretion (NAEes) with CKD; and socio-demographic and clinical correlates of NAEes. Methods Among 12,293 U.S. adult participants aged >20 years in the National Health and Nutrition Examination Survey 1999–2004, we assessed dietary acid by estimating NAEes from nutrient intake and body surface area; kidney damage by albuminuria; and kidney dysfunction by eGFR < 60 ml/min/1.73m2 using the MDRD equation. We tested the association of NAEes with participant characteristics using median regression; while for albuminuria, eGFR, and stages of CKD we used logistic regression. Results Median regression results (β per quintile) indicated that adults aged 40–60 years (β [95% CI] = 3.1 [0.3–5.8]), poverty (β [95% CI] = 7.1 [4.01–10.22]), black race (β [95% CI] = 13.8 [10.8–16.8]), and male sex (β [95% CI] = 3.0 [0.7- 5.2]) were significantly associated with an increasing level of NAEes. Higher levels of NAEes compared with lower levels were associated with greater odds of albuminuria (OR [95% CI] = 1.57 [1.20–2.05]). We observed a trend toward greater NAEes being associated with higher risk of low eGFR, which persisted after adjustment for confounders. Conclusion Higher NAEes is associated with albuminuria and low eGFR, and socio-demographic risk factors for CKD are associated with higher levels of NAEes. DAL may be an important target for future interventions in populations at high risk for CKD. | |
dc.title | Dietary acid load and chronic kidney disease among adults in the United States | |
dc.type | Article | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/109474/1/12882_2014_Article_829.pdf | |
dc.identifier.doi | 10.1186/1471-2369-15-137 | en_US |
dc.language.rfc3066 | en | |
dc.rights.holder | Banerjee et al.; licensee BioMed Central Ltd. | |
dc.date.updated | 2014-12-08T17:45:14Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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