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Genome‐wide scans of genetic variants for psychophysiological endophenotypes: A methodological overview
dc.contributor.authorIacono, William. G.en_US
dc.contributor.authorMalone, Stephen. M.en_US
dc.contributor.authorVaidyanathan, Umaen_US
dc.contributor.authorVrieze, Scott I.en_US
dc.date.accessioned2014-12-09T16:53:43Z
dc.date.availableWITHHELD_13_MONTHSen_US
dc.date.available2014-12-09T16:53:43Z
dc.date.issued2014-12en_US
dc.identifier.citationIacono, William. G.; Malone, Stephen. M.; Vaidyanathan, Uma; Vrieze, Scott I. (2014). "Genome‐wide scans of genetic variants for psychophysiological endophenotypes: A methodological overview." Psychophysiology (12): 1207-1224.en_US
dc.identifier.issn0048-5772en_US
dc.identifier.issn1469-8986en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/109594
dc.description.abstractThis article provides an introductory overview of the investigative strategy employed to evaluate the genetic basis of 17 endophenotypes examined as part of a 20‐year data collection effort from the M innesota C enter for T win and F amily R esearch. Included are characterization of the study samples, descriptive statistics for key properties of the psychophysiological measures, and rationale behind the steps taken in the molecular genetic study design. The statistical approach included (a) biometric analysis of twin and family data, (b) heritability analysis using 527,829 single nucleotide polymorphisms ( SNPs ), (c) genome‐wide association analysis of these SNPs and 17,601 autosomal genes, (d) follow‐up analyses of candidate SNPs and genes hypothesized to have an association with each endophenotype, (e) rare variant analysis of nonsynonymous SNPs in the exome, and (f) whole genome sequencing association analysis using 27 million genetic variants. These methods were used in the accompanying empirical articles comprising this special issue, Genome‐Wide Scans of Genetic Variants for Psychophysiological Endophenotypes .en_US
dc.publisherNational Institute on Drug Abuseen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherExome Chipen_US
dc.subject.otherEndophenotypeen_US
dc.subject.otherBiometric Modelingen_US
dc.subject.otherWhole Genome Sequencingen_US
dc.subject.otherGenome‐Wide Association Studyen_US
dc.subject.otherGenome‐Wide Complex Trait Analysisen_US
dc.titleGenome‐wide scans of genetic variants for psychophysiological endophenotypes: A methodological overviewen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysiologyen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/109594/1/psyp12343.pdf
dc.identifier.doi10.1111/psyp.12343en_US
dc.identifier.sourcePsychophysiologyen_US
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