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Morphology and connectivity of parabrachial and cortical inputs to gustatory thalamus in rats
dc.contributor.authorHoltz, Stephen L.en_US
dc.contributor.authorFu, Anqien_US
dc.contributor.authorLoflin, Wyatten_US
dc.contributor.authorCorson, James A.en_US
dc.contributor.authorErisir, Aleven_US
dc.date.accessioned2014-12-09T16:54:08Z
dc.date.available2016-03-02T19:36:56Zen
dc.date.issued2015-01-01en_US
dc.identifier.citationHoltz, Stephen L.; Fu, Anqi; Loflin, Wyatt; Corson, James A.; Erisir, Alev (2015). "Morphology and connectivity of parabrachial and cortical inputs to gustatory thalamus in rats." Journal of Comparative Neurology 523(1): 139-161.en_US
dc.identifier.issn0021-9967en_US
dc.identifier.issn1096-9861en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/109654
dc.description.abstractThe ventroposterior medialis parvocellularis (VPMpc) nucleus of the thalamus, the thalamic relay nucleus for gustatory sensation, receives primary input from the parabrachial nucleus, and projects to the insular cortex. To reveal the unique properties of the gustatory thalamus in comparison with archetypical sensory relay nuclei, this study examines the morphology of synaptic circuitry in the VPMpc, focusing on parabrachiothalamic driver input and corticothalamic feedback. Anterogradely visualized parabrachiothalamic fibers in the VPMpc bear large swellings. At electron microscope resolution, parabrachiothalamic axons are myelinated and make large boutons, forming multiple asymmetric, adherent, and perforated synapses onto large‐caliber dendrites and dendrite initial segments. Labeled boutons contain dense‐core vesicles, and they resemble a population of terminals within the VPMpc containing calcitonin gene‐related peptide. As is typical of primary inputs to other thalamic nuclei, parabrachiothalamic terminals are over five times larger than other inputs, while constituting only 2% of all synapses. Glomeruli and triadic arrangements, characteristic features of other sensory thalamic nuclei, are not encountered. As revealed by anterograde tracer injections into the insular cortex, corticothalamic projections in the VPMpc form a dense network of fine fibers bearing small boutons. Corticothalamic terminals within the VPMpc were also observed to synapse on cells that were retrogradely filled from the same injections. The results constitute an initial survey describing unique anatomical properties of the rodent gustatory thalamus. J. Comp. Neurol. 523:139–161, 2015. © 2014 Wiley Periodicals, Inc. Using biotinylated tract tracers and light and electron microscopy, the authors provide quantitative ultrastructural characterization of two inputs that arrive to the gustatory thalamic nucleus (ventroposterior medialis parvocellularis nucleus [VPMpc]): parabrachiothalamic axons that bring the primary input, and corticothalamic axons that provide the feedback input.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.publisherAcademic Pressen_US
dc.subject.otherRid_000042en_US
dc.subject.otherNlx_152120en_US
dc.subject.otherNif‐0000–23420en_US
dc.subject.otherVentroposteromedial Thalamusen_US
dc.subject.otherCortical Feedbacken_US
dc.subject.otherCGRPen_US
dc.subject.otherElectron Microscopyen_US
dc.subject.other3D Reconstructionen_US
dc.subject.otherRGD_70508en_US
dc.subject.otherAB_2336827en_US
dc.subject.otherAB_259000en_US
dc.subject.otherAB_2336171en_US
dc.titleMorphology and connectivity of parabrachial and cortical inputs to gustatory thalamus in ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/109654/1/cne23673.pdf
dc.identifier.doi10.1002/cne.23673en_US
dc.identifier.sourceJournal of Comparative Neurologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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