Human papillomavirus–related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor
dc.contributor.author | Vainshtein, Jeffrey | en_US |
dc.contributor.author | McHugh, Jonathan B. | en_US |
dc.contributor.author | Spector, Matthew E. | en_US |
dc.contributor.author | Walline, Heather M. | en_US |
dc.contributor.author | Komarck, Christine M. | en_US |
dc.contributor.author | Stenmark, Matthew H. | en_US |
dc.contributor.author | Prince, Mark E. | en_US |
dc.contributor.author | Worden, Francis P. | en_US |
dc.contributor.author | Wolf, Gregory T. | en_US |
dc.contributor.author | Bradford, Carol R. | en_US |
dc.contributor.author | Chepeha, Douglas B. | en_US |
dc.contributor.author | Carey, Thomas | en_US |
dc.contributor.author | Eisbruch, Avraham | en_US |
dc.date.accessioned | 2015-01-07T15:22:58Z | |
dc.date.available | 2016-03-02T19:36:56Z | en |
dc.date.issued | 2015-01 | en_US |
dc.identifier.citation | Vainshtein, Jeffrey; McHugh, Jonathan B.; Spector, Matthew E.; Walline, Heather M.; Komarck, Christine M.; Stenmark, Matthew H.; Prince, Mark E.; Worden, Francis P.; Wolf, Gregory T.; Bradford, Carol R.; Chepeha, Douglas B.; Carey, Thomas; Eisbruch, Avraham (2015). "Human papillomavirus–related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor." Head & Neck 37(1): 8-11. | en_US |
dc.identifier.issn | 1043-3074 | en_US |
dc.identifier.issn | 1097-0347 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/109811 | |
dc.description.abstract | Background Although typically associated with a favorable prognosis, a minority of human papillomavirus (HPV)‐related (+) oropharyngeal cancers recur after chemoradiation. We postulated that a minor HPV‐negative tumor subfraction may be responsible for recurrences of HPV+ oropharyngeal cancer. Methods Paired untreated primary and recurrent tumor specimens were identified for 37 patients with oropharyngeal cancer who received definitive chemoradiotherapy at our institution. Concordance in HPV/p16 expression between primary and recurrent tumors was assessed. Results Among 31 patients with HPV+/p16+ primary tumors, 30 (97%) retained evidence of both HPV and p16 expression at recurrence (27 HPV+/p16+; 3 HPV+/p16‐partial). One (3%) initially HPV+/p16+ patient developed an HPV‐negative/p16‐negative lung squamous cell carcinoma (SCC), representing either a discordant oropharyngeal cancer metastasis or second primary tumor. Conclusion HPV‐related oropharyngeal cancers retain HPV+/p16+ expression at recurrence. Our results fail to provide evidence that a minor HPV‐negative tumor subfraction is responsible for biologically aggressive behavior of HPV+ oropharyngeal cancer that recurs after chemoradiation. © 2014 Wiley Periodicals, Inc. Head Neck 37 : 8–11, 2015 | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Chemoradiation | en_US |
dc.subject.other | Oropharyngeal Cancer | en_US |
dc.subject.other | P16 | en_US |
dc.subject.other | Human Papillomavirus | en_US |
dc.subject.other | Expression Profiling | en_US |
dc.title | Human papillomavirus–related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/109811/1/hed23548.pdf | |
dc.identifier.doi | 10.1002/hed.23548 | en_US |
dc.identifier.source | Head & Neck | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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