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Sculpting Metal‐binding Environments in De Novo Designed Three‐helix Bundles
dc.contributor.authorPlegaria, Jefferson S.en_US
dc.contributor.authorPecoraro, Vincent L.en_US
dc.date.accessioned2015-02-19T15:40:54Z
dc.date.available2016-03-02T19:36:56Zen
dc.date.issued2015-01en_US
dc.identifier.citationPlegaria, Jefferson S.; Pecoraro, Vincent L. (2015). "Sculpting Metal‐binding Environments in De Novo Designed Three‐helix Bundles." Israel Journal of Chemistry 55(1): 85-95.en_US
dc.identifier.issn0021-2148en_US
dc.identifier.issn1869-5868en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/110624
dc.description.abstractDe novo protein design is a biologically relevant approach used to study the active centers of native metalloproteins. In this review, we will first discuss the design process in achieving α3D, a de novo designed three‐helix bundle peptide with a well‐defined fold. We will then cover our recent work in functionalizing the α3D framework by incorporating a tris(cysteine) and tris(histidine) motif. Our first design contains the thiol‐rich sites found in metalloregulatory proteins that control the levels of toxic metal ions (Hg, Cd, and Pb). The latter design recapitulates the catalytic site and activity of a natural metalloenzyme carbonic anhydrase. The review will conclude with future design goals aimed at introducing an asymmetric metal‐binding site in the α3D framework.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherthree‐helix bundlesen_US
dc.subject.otherprotein designen_US
dc.subject.otherthree‐stranded coiled‐coilsen_US
dc.subject.othermetal ionsen_US
dc.subject.othermetalloproteinsen_US
dc.titleSculpting Metal‐binding Environments in De Novo Designed Three‐helix Bundlesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum930 North University Ave, Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 (USA), Tel: (+1) 734‐763‐1519en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/110624/1/85_ftp.pdf
dc.identifier.doi10.1002/ijch.201400146en_US
dc.identifier.sourceIsrael Journal of Chemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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