View Item 

Show simple item record

Sculpting Metal‐binding Environments in De Novo Designed Three‐helix Bundles
dc.contributor.authorPlegaria, Jefferson S.en_US
dc.contributor.authorPecoraro, Vincent L.en_US
dc.date.accessioned2015-02-19T15:40:54Z
dc.date.available2016-03-02T19:36:56Zen
dc.date.issued2015-01en_US
dc.identifier.citationPlegaria, Jefferson S.; Pecoraro, Vincent L. (2015). "Sculpting Metal‐binding Environments in De Novo Designed Three‐helix Bundles." Israel Journal of Chemistry 55(1): 85-95.en_US
dc.identifier.issn0021-2148en_US
dc.identifier.issn1869-5868en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/110624
dc.description.abstractDe novo protein design is a biologically relevant approach used to study the active centers of native metalloproteins. In this review, we will first discuss the design process in achieving α3D, a de novo designed three‐helix bundle peptide with a well‐defined fold. We will then cover our recent work in functionalizing the α3D framework by incorporating a tris(cysteine) and tris(histidine) motif. Our first design contains the thiol‐rich sites found in metalloregulatory proteins that control the levels of toxic metal ions (Hg, Cd, and Pb). The latter design recapitulates the catalytic site and activity of a natural metalloenzyme carbonic anhydrase. The review will conclude with future design goals aimed at introducing an asymmetric metal‐binding site in the α3D framework.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherthree‐helix bundlesen_US
dc.subject.otherprotein designen_US
dc.subject.otherthree‐stranded coiled‐coilsen_US
dc.subject.othermetal ionsen_US
dc.subject.othermetalloproteinsen_US
dc.titleSculpting Metal‐binding Environments in De Novo Designed Three‐helix Bundlesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum930 North University Ave, Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 (USA), Tel: (+1) 734‐763‐1519en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/110624/1/85_ftp.pdf
dc.identifier.doi10.1002/ijch.201400146en_US
dc.identifier.sourceIsrael Journal of Chemistryen_US
dc.identifier.citedreferenceG. Öz, D. L. Pountney, I. M. Armitage, Biochem. Cell Biol. 1998, 76, 223 – 234.en_US
dc.identifier.citedreferenceJ. G. Wright, H. T. Tsang, J. E. Penner‐Hahn, T. V. O′Halloran, J. Am. Chem. Soc. 1990, 112, 2434 – 2435.en_US
dc.identifier.citedreferenceL. Banci, I. Bertini, F. Cantini, S. Ciofi‐Baffoni, J. S. Cavet, C. Dennison, A. I. Graham, D. R. Harvie, N. J. Robinson, J. Biol. Chem. 2007, 282, 30181 – 30188.en_US
dc.identifier.citedreferenceJ. Ye, A. Kandegedara, P. Martin, B. P. Rosen, J. Bacteriol. 2005, 187, 4214 – 4221.en_US
dc.identifier.citedreferenceI. Armitage, T. Drakenberg, B. Reilly, Met. Ions Life Sci. 2013, 11, 117 – 144.en_US
dc.identifier.citedreferenceL. Hemmingsen, M. Stachura, P. W. Thulstrup, N. J. Christensen, K. Johnston, Hyperfine Interact. 2010, 197, 255 – 267.en_US
dc.identifier.citedreferenceS. Chakraborty, PhD thesis, University of Michigan (USA), 2011.en_US
dc.identifier.citedreferenceH. Song, D. L. Wilson, E. R. Farquhar, E. A. Lewis, J. P. Emerson, Inorg. Chem. 2012, 51, 11098 – 11105.en_US
dc.identifier.citedreferenceR. G. Khalifah, J. Biol. Chem. 1971, 246, 2561 – 2573.en_US
dc.identifier.citedreferenceR. M. Rush, J. H. Yoe, Anal. Chem. 1954, 26, 1345 – 1347.en_US
dc.identifier.citedreferenceH. Slebocka‐Tilk, J. L. Cocho, Z. Frakman, R. S. Brown, J. Am. Chem. Soc. 1984, 106, 2421 – 2431.en_US
dc.identifier.citedreferenceK. Nakata, N. Shimomura, N. Shiina, M. Izumi, K. Ichikawa, M. Shiro, J. Inorg. Biochem. 2002, 89, 255 – 266.en_US
dc.identifier.citedreferenceJ. E. Jackman, K. M. Merz Jr, C. A. Fierke, Biochemistry 1996, 35, 16421 – 16428.en_US
dc.identifier.citedreferenceD. A. Jewell, C. Tu, S. R. Paranawithana, S. M. Tanhauser, P. V. LoGrasso, P. J. Laipis, D. N. Silverman, Biochemistry 1991, 30, 1484 – 1490.en_US
dc.identifier.citedreferenceZ. Liang, Y. Xue, G. Behravan, B.‐H. Jonsson, S. Lindskog, Eur. J. Biochem. 1993, 211, 821 – 827.en_US
dc.identifier.citedreferenceE. I. Solomon, R. K. Szilagyi, S. DeBeer George, L. Basumallick, Chem. Rev. 2004, 104, 419 – 458.en_US
dc.identifier.citedreferenceB. G. Malmström, FEBS 1994, 223, 711 – 718.en_US
dc.identifier.citedreferenceD. Shiga, D. Nakane, T. Inomata, Y. Funahashi, H. Masuda, A. Kikuchi, M. Oda, M. Noda, S. Uchiyama, K. Fukui, K. Kanaori, K. Tajima, Y. Takano, H. Nakamura, T. Tanaka, J. Am. Chem. Soc. 2010, 132, 18191 – 18198.en_US
dc.identifier.citedreferenceC. T. Choma, J. D. Lear, M. J. Nelson, P. L. Dutton, D. E. Robertson, W. F. DeGrado, J. Am. Chem. Soc. 1994, 116, 856 – 865.en_US
dc.identifier.citedreferenceA. Lombardi, C. M. Summa, S. Geremia, L. Randaccio, V. Pavone, W. F. DeGrado, Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 6298 – 6305.en_US
dc.identifier.citedreferenceJ. Zhuang, J. H. Amoroso, R. Kinloch, J. H. Dawson, M. J. Baldwin, B. R. Gibney, Inorg. Chem. 2004, 43, 8218 – 8220.en_US
dc.identifier.citedreferenceS. S. Huang, R. L. Koder, M. Lewis, A. J. Wand, P. L. Dutton, H. B. Gray, Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 5536 – 554.en_US
dc.identifier.citedreferenceK. J. Waldron, J. C. Rutherford, D. Ford, N. J. Robinson, Nature 2009, 460, 823 – 830.en_US
dc.identifier.citedreferenceY. Lu, S. M. Berry, T. D. Pfister, Chem. Rev. 2001, 101, 3047 – 3080.en_US
dc.identifier.citedreferenceY. Lu, N. Yeung, N. Sieracki, N. M. Marshall, Nature 2009, 460, 855 – 862.en_US
dc.identifier.citedreferenceF. Yu, V. M. Cangelosi, M. L. Zastrow, M. Tegoni, J. S. Plegaria, A. G. Tebo, C. S. Mocny, L. Ruckthong, H. Qayyum, V. L. Pecoraro, Chem. Rev. 2014, 114, 3495 – 3578.en_US
dc.identifier.citedreferenceM. L. Zastrow, V. L. Pecoraro, Coord. Chem. Rev. 2013, 257, 2565 – 2588.en_US
dc.identifier.citedreferenceW. F. DeGrado, C. M. Summa, V. Pavone, F. Nastri, A. Lombardi, Annu. Rev. Biochem. 1999, 68, 779 – 819.en_US
dc.identifier.citedreferenceD. Ghosh, V. L. Pecoraro, Curr. Opin. Chem. Biol. 2005, 9, 97 – 103.en_US
dc.identifier.citedreferenceD. P. Giedroc, A. I. Arunkumar, Dalton Trans. 2007, 3107 – 3120.en_US
dc.identifier.citedreferenceS. T. R. Walsh, H. Cheng, J. W. Bryson, H. Roder, W. F. DeGrado, Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 5486 – 5491.en_US
dc.identifier.citedreferenceL. S. Busenlehner, T. C. Weng, J. E. Penner‐Hahn, D. P. Giedroc, J. Mol. Biol. 2002, 319, 685 – 701.en_US
dc.identifier.citedreferenceS. Chakraborty, J. Yudenfreund‐Kravitz, P. W. Thulstrup, L. Hemmingsen, W. F. DeGrado, V. L. Pecoraro, Angew. Chem. Int. Ed. 2011, 50, 2049 – 2053.en_US
dc.identifier.citedreferenceV. M. Cangelosi, A. Deb, J. E. Penner‐Hahn, V. L. Pecoraro, Angew. Chem. Int. Ed. 2014, 53, 7900 – 7903.en_US
dc.identifier.citedreferenceJ. F. Krebs, J. A. Ippolito, D. W. Christianson, C. A. Fierke, J. Biol. Chem. 1993, 268, 27458 – 27466.en_US
dc.identifier.citedreferenceJ. M. Guss, H. D. Bartunik, H. C. Freeman, Acta Crystallogr. Sect. B: Struct. Sci. 1992, 48, 790 – 811.en_US
dc.identifier.citedreferenceA. F. A. Peacock, O. Iranzo, V. L. Pecoraro, Dalton Trans. 2009, 2271 – 2280.en_US
dc.identifier.citedreferenceD. Ghosh, V. L. Pecoraro, Inorg. Chem. 2004, 43, 7902 – 7915.en_US
dc.identifier.citedreferenceG. R. Dieckmann, D. K. McRorie, D. L. Tierney, L. M. Utschig, C. P. Singer, T. V. O’Halloran, J. E. Penner‐Hahn, W. F. DeGrado, V. L. Pecoraro, J. Am. Chem. Soc. 1997, 119, 6195 – 6196.en_US
dc.identifier.citedreferenceG. R. Dieckmann, D. K. McRorie, J. D. Lear, K. A. Sharp, W. F. DeGrado, V. L. Pecoraro, J. Mol. Biol. 1998, 280, 897 – 912.en_US
dc.identifier.citedreferenceB. T. Farrer, N. P. Harris, K. E. Balchus, V. L. Pecoraro, Biochemistry 2001, 40, 14696 – 14705.en_US
dc.identifier.citedreferenceM. Matzapetakis, B. T. Farrer, T.‐C. Weng, L. Hemmingsen, J. E. Penner‐Hahn, V. L. Pecoraro, J. Am. Chem. Soc. 2002, 124, 8042 – 8054.en_US
dc.identifier.citedreferenceK. H. Lee, M. Matzapetakis, S. Mitra, E. N. Marsh, V. L. Pecoraro, J. Am. Chem. Soc. 2004, 126, 9178 – 9179.en_US
dc.identifier.citedreferenceM. Matzapetakis, D. Ghosh, T. C. Weng, J. E. Penner‐Hahn, V. L. Pecoraro, J. Biol. Inorg. Chem. 2006, 11, 876 – 890.en_US
dc.identifier.citedreferenceO. Iranzo, D. Ghosh, V. L. Pecoraro, Inorg. Chem. 2006, 45, 9959 – 9973.en_US
dc.identifier.citedreferenceO. Iranzo, P. W. Thulstrup, S. Ryu, L. Hemmingsen, V. L. Pecoraro, Chem. Eur. J. 2007, 13, 9178 – 9190.en_US
dc.identifier.citedreferenceO. Iranzo, C. Cabello, V. L. Pecoraro, Angew. Chem. Int. Ed. 2007, 46, 6688 – 6691.en_US
dc.identifier.citedreferenceM. Łuczkowski, M. Stachura, V. Schirf, B. Demeler, L. Hemmingsen, V. L. Pecoraro, Inorg. Chem. 2008, 47, 10875 – 88.en_US
dc.identifier.citedreferenceA. F. A. Peacock, L. Hemmingsen, V. L. Pecoraro, Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 16566 – 16571.en_US
dc.identifier.citedreferenceM. L. Zastrow, A. F. A. Peacock, J. A. Stuckey, V. L. Pecoraro, Nat. Chem. 2011, 4, 118 – 123.en_US
dc.identifier.citedreferenceG. Zampella, K. P. Neupane, L. De Gioia, V. L. Pecoraro, Chem. Eur. J. 2012, 18, 2040 – 2050.en_US
dc.identifier.citedreferenceM. Tegoni, F. Yu, M. Bersellini, J. E. Penner‐Hahn, V. L. Pecoraro, Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 21234 – 21239.en_US
dc.identifier.citedreferenceM. L. Zastrow, V. L. Pecoraro, J. Am. Chem. Soc. 2013, 135, 5895 – 5903.en_US
dc.identifier.citedreferenceF. Yu, J. E. Penner‐Hahn, V. L. Pecoraro, J. Am. Chem. Soc. 2013, 135, 18096 – 18107.en_US
dc.identifier.citedreferenceO. Iranzo, S. Chakraborty, L. Hemmingsen, V. L. Pecoraro, J. Am. Chem. Soc. 2011, 133, 239 – 251.en_US
dc.identifier.citedreferenceK. P. Neupane, V. L. Pecoraro, Angew. Chem. Int. Ed. 2010, 49, 8177 – 8180.en_US
dc.identifier.citedreferenceB. T. Farrer, V. L. Pecoraro, Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3760 – 3765.en_US
dc.identifier.citedreferenceD. S. Touw, C. E. Nordman, J. A. Stuckey, V. L. Pecoraro, Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 11969 – 11974.en_US
dc.identifier.citedreferenceA. F. A. Peacock, J. A. Stuckey, V. L. Pecoraro, Angew. Chem. Int. Ed. 2009, 48, 7371 – 7374.en_US
dc.identifier.citedreferenceS. Chakraborty, D. S. Touw, A. F. A. Peacock, J. A. Stuckey, V. L. Pecoraro, J. Am. Chem. Soc. 2010, 132, 13240 – 13250.en_US
dc.identifier.citedreferenceK. P. Neupane, V. L. Pecoraro, J. Inorg. Biochem. 2011, 105, 1030 – 1034.en_US
dc.identifier.citedreferenceB. S. Avvaru, C. U. Kim, K. H. Sippel, S. M. Gruner, M. Agbandje‐McKenna, D. N. Silverman, R. McKenna, Biochemistry 2010, 49, 249 – 251.en_US
dc.identifier.citedreferenceB. Lovejoy, S. Choe, D. Cascio, D. K. McRorie, W. F. DeGrado, D. Eisenberg, Science 1993, 259, 1288 – 1293.en_US
dc.identifier.citedreferenceJ. W. Bryson, J. R. Desjarlais, T. M. Handel, W. F. DeGrado, Protein Sci. 1998, 7, 1404 – 1414.en_US
dc.identifier.citedreferenceS. T. R. Walsh, A. L. Lee, W. F. DeGrado, A. J. Wand, Biochemistry 2001, 40, 9560 – 9569.en_US
dc.identifier.citedreferenceS. T. R. Walsh, R. P. Cheng, W. W. Wright, D. O. V. Alonso, V. Daggett, J. M. Vanderkooi, W. F. DeGrado, Protein Sci. 2003, 12, 520 – 531.en_US
dc.identifier.citedreferenceY. Zhu, D. O. V. Alonso, K. Maki, C.‐Y. Huang, S. J. Lahr, V. Daggett, H. Roder, W. F. DeGrado, F. Gai, Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 15486 – 15491.en_US
dc.identifier.citedreferenceS. T. R. Walsh, V. I. Sukharev, S. F. Betz, N. L. Vekshin, W. F. DeGrado, J. Mol. Biol. 2001, 305, 361 – 373.en_US
dc.identifier.citedreferenceT. V. O’Halloran, C. Walsh, Science 1987, 235, 211 – 214.en_US
dc.identifier.citedreferenceJ. G. Wright, M. J. Natan, F. M. MacDonnel, D. M. Ralston, T. V. O′Halloran, Prog. Inorg. Chem. 1990, 38, 323 – 412.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
85_ftp.pdf
Size:
1.085MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.