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Reduced executive and default network functional connectivity in cigarette smokers

dc.contributor.authorWeiland, Barbara J.en_US
dc.contributor.authorSabbineni, Amithrupaen_US
dc.contributor.authorCalhoun, Vince D.en_US
dc.contributor.authorWelsh, Robert C.en_US
dc.contributor.authorHutchison, Kent E.en_US
dc.date.accessioned2015-03-05T18:24:43Z
dc.date.available2016-05-10T20:26:28Zen
dc.date.issued2015-03en_US
dc.identifier.citationWeiland, Barbara J.; Sabbineni, Amithrupa; Calhoun, Vince D.; Welsh, Robert C.; Hutchison, Kent E. (2015). "Reduced executive and default network functional connectivity in cigarette smokers." Human Brain Mapping 36(3): 872-882.en_US
dc.identifier.issn1065-9471en_US
dc.identifier.issn1097-0193en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/110754
dc.description.abstractAltered functional connectivity has been associated with acute and chronic nicotine use. Connectivity alterations, specifically in the right and left executive control networks (RECN/LECN) and the default mode network (DMN), may contribute to the addiction cycle. The objective of this study was to determine if executive control network (ECN) and DMN connectivity is different between non‐smokers and smokers and whether reductions in connectivity are related to chronic cigarette use. The RECN, LECN, and DMN were identified in resting state functional magnetic resonance imaging data in 650 subjects. Analyses tested for group differences in network connectivity strength, controlling for age and alcohol use. There was a significant group effect on LECN and DMN connectivity strength with smokers (n = 452) having lower network strengths than non‐smokers (n = 198). Smokers had lower connectivity than non‐smokers associated with key network hubs: the dorsolateral prefrontal cortex, and parietal nodes within ECNs. Further, ECN connectivity strength was negatively associated with pack years of cigarette use. Our data suggest that chronic nicotine use negatively impacts functional connectivity within control networks that may contribute to the difficulty smokers have in quitting. Hum Brain Mapp 36:872–882, 2015. © 2014 Wiley Periodicals, Inc.en_US
dc.publisherAmerican Physiological Societyen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherresting stateen_US
dc.subject.othersmokingen_US
dc.subject.otherfunctional connectivityen_US
dc.subject.otherexecutive control networken_US
dc.subject.othercigaretteen_US
dc.subject.otherdefault mode networken_US
dc.subject.othernicotineen_US
dc.titleReduced executive and default network functional connectivity in cigarette smokersen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelKinesiology and Sportsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/110754/1/hbm22672.pdf
dc.identifier.doi10.1002/hbm.22672en_US
dc.identifier.sourceHuman Brain Mappingen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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