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Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults
dc.contributor.authorKoppelmans, Vincenten_US
dc.contributor.authorHirsiger, Sarahen_US
dc.contributor.authorMérillat, Susanen_US
dc.contributor.authorJäncke, Lutzen_US
dc.contributor.authorSeidler, Rachael D.en_US
dc.date.accessioned2015-05-04T20:35:50Z
dc.date.available2016-07-05T17:27:59Zen
dc.date.issued2015-06en_US
dc.identifier.citationKoppelmans, Vincent; Hirsiger, Sarah; Mérillat, Susan ; Jäncke, Lutz ; Seidler, Rachael D. (2015). "Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults." Human Brain Mapping 36(6): 2352-2363.en_US
dc.identifier.issn1065-9471en_US
dc.identifier.issn1097-0193en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/111082
dc.description.abstractObjectivesFunctional neuroimaging and voxel‐based morphometry studies have confirmed the important role of the cerebellum in motor behavior. However, little is known about the relationship between cerebellar gray (GMv) and white matter (WMv) volume and manual motor performance in aging individuals. This study aims to quantify the relationship between cerebellar tissue volume and manual motor performance.Experimental designTo gain more insight into cerebellar function and how it relates to the role of the primary motor cortex (M1), we related cerebellar GMv, WMv, and M1v to manual motor performance in 217 healthy older individuals. Left and right cerebellar GMv and WMv, and M1v were obtained using FreeSurfer. The following motor measures were obtained: grip force, tapping speed, bimanual visuomotor coordination, and manual dexterity.Principal observationsSignificant positive relationships were observed between cerebellar GMv and WMv and grip strength, right cerebellar WMv and right‐hand tapping speed, right cerebellar WMv and dexterity, M1v and grip strength, and right M1v and left‐hand dexterity, though effect sizes were small.ConclusionsOur results show that cerebellar GMv and WMv are differently associated with manual motor performance. These associations partly overlap with the brain‐behavior associations between M1 and manual motor performance. Not all observed associations were lateralized (i.e., ipsilateral cerebellar and contralateral M1v associations with motor performance), which could point to age‐related neural dedifferentiation. The current study provides new insights in the role of the cerebellum in manual motor performance. In consideration of the small effect sizes replication studies are needed to validate these results. Hum Brain Mapp 36:2352–2363, 2015. © 2015 Wiley Periodicals, Inc.en_US
dc.publisherSpringeren_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.othergray matteren_US
dc.subject.otherMRIen_US
dc.subject.otherwhite matteren_US
dc.subject.othermotor functionen_US
dc.subject.othercerebellumen_US
dc.subject.othervolumeen_US
dc.titleCerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adultsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelKinesiology and Sportsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/111082/1/hbm22775.pdf
dc.identifier.doi10.1002/hbm.22775en_US
dc.identifier.sourceHuman Brain Mappingen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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