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Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland
dc.contributor.authorCastro, Analía E.en_US
dc.contributor.authorBenitez, Sergio G.en_US
dc.contributor.authorFarias Altamirano, Luz E.en_US
dc.contributor.authorSavastano, Luis E.en_US
dc.contributor.authorPatterson, Sean I.en_US
dc.contributor.authorMuñoz, Estela M.en_US
dc.date.accessioned2015-05-04T20:36:35Z
dc.date.available2016-07-05T17:27:59Zen
dc.date.issued2015-05en_US
dc.identifier.citationCastro, Analía E. ; Benitez, Sergio G.; Farias Altamirano, Luz E.; Savastano, Luis E.; Patterson, Sean I.; Muñoz, Estela M. (2015). "Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland." Journal of Pineal Research 58(4): 439-451.en_US
dc.identifier.issn0742-3098en_US
dc.identifier.issn1600-079Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/111177
dc.description.abstractCircadian rhythms govern many aspects of mammalian physiology. The daily pattern of melatonin synthesis and secretion is one of the classic examples of circadian oscillations. It is mediated by a class of neuroendocrine cells known as pinealocytes which are not yet fully defined. An established method to evaluate functional and cytological characters is through the expression of lineage‐specific transcriptional regulators. NeuroD1 is a basic helix‐loop‐helix transcription factor involved in the specification and maintenance of both endocrine and neuronal phenotypes. We have previously described developmental and adult regulation of NeuroD1 mRNA in the rodent pineal gland. However, the transcript levels were not influenced by the elimination of sympathetic input, suggesting that any rhythmicity of NeuroD1 might be found downstream of transcription. Here, we describe NeuroD1 protein expression and cellular localization in the rat pineal gland during development and the daily cycle. In embryonic and perinatal stages, protein expression follows the mRNA pattern and is predominantly nuclear. Thereafter, NeuroD1 is mostly found in pinealocyte nuclei in the early part of the night and in cytoplasm during the day, a rhythm maintained into adulthood. Additionally, nocturnal nuclear NeuroD1 levels are reduced after sympathetic disruption, an effect mimicked by the in vivo administration of α‐ and β‐adrenoceptor blockers. NeuroD1 phosphorylation at two sites, Ser274 and Ser336, associates with nuclear localization in pinealocytes. These data suggest that NeuroD1 influences pineal phenotype both during development and adulthood, in an autonomic and phosphorylation‐dependent manner.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherNeuroD1en_US
dc.subject.othernuclear–cytoplasmic partitioningen_US
dc.subject.otherserine residuesen_US
dc.subject.otherpost‐translational modificationsen_US
dc.subject.otherpineal glanden_US
dc.subject.otherphosphorylationen_US
dc.titleExpression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal glanden_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/111177/1/jpi12228.pdf
dc.identifier.doi10.1111/jpi.12228en_US
dc.identifier.sourceJournal of Pineal Researchen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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