Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans
dc.contributor.author | Zahn, Joseph | |
dc.contributor.author | Kaplan, Mark H | |
dc.contributor.author | Fischer, Sabrina | |
dc.contributor.author | Dai, Manhong | |
dc.contributor.author | Meng, Fan | |
dc.contributor.author | Saha, Anjan K | |
dc.contributor.author | Cervantes, Patrick | |
dc.contributor.author | Chan, Susana M | |
dc.contributor.author | Dube, Derek | |
dc.contributor.author | Omenn, Gilbert S | |
dc.contributor.author | Markovitz, David M | |
dc.contributor.author | Contreras-Galindo, Rafael | |
dc.date.accessioned | 2015-05-08T18:01:27Z | |
dc.date.available | 2015-05-08T18:01:27Z | |
dc.date.issued | 2015-04-12 | |
dc.identifier.citation | Genome Biology. 2015 Apr 12;16(1):74 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/111301 | en_US |
dc.description.abstract | Abstract Background Approximately 8% of the human genome consists of sequences of retroviral origin, a result of ancestral infections of the germ line over millions of years of evolution. The most recent of these infections is attributed to members of the human endogenous retrovirus type-K (HERV-K) (HML-2) family. We recently reported that a previously undetected, large group of HERV-K (HML-2) proviruses, which are descendants of the ancestral K111 infection, are spread throughout human centromeres. Results Studying the genomes of certain cell lines and the DNA of healthy individuals that seemingly lack K111, we discover new HERV-K (HML-2) members hidden in pericentromeres of several human chromosomes. All are related through a common ancestor, termed K222, which is a virus that infected the germ line approximately 25 million years ago. K222 exists as a single copy in the genomes of baboons and high order primates, but not New World monkeys, suggesting that progenitor K222 infected the primate germ line after the split between New and Old World monkeys. K222 exists in modern humans at multiple loci spread across the pericentromeres of nine chromosomes, indicating it was amplified during the evolution of modern humans. Conclusions Copying of K222 may have occurred through recombination of the pericentromeres of different chromosomes during human evolution. Evidence of recombination between K111 and K222 suggests that these retroviral sequences have been templates for frequent cross-over events during the process of centromere recombination in humans. | |
dc.title | Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans | |
dc.type | Article | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/111301/1/13059_2015_Article_641.pdf | |
dc.identifier.doi | 10.1186/s13059-015-0641-1 | en_US |
dc.language.rfc3066 | en | |
dc.rights.holder | Zahn et al.; licensee BioMed Central. | |
dc.date.updated | 2015-05-08T18:01:27Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.