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Educational attainment and motor burden in Parkinson's disease

dc.contributor.authorKotagal, Vikasen_US
dc.contributor.authorBohnen, Nicolaas I.en_US
dc.contributor.authorMüller, Martijn L.t.m.en_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.contributor.authorFrey, Kirk A.en_US
dc.contributor.authorLanga, Kenneth M.en_US
dc.contributor.authorAlbin, Roger L.en_US
dc.date.accessioned2015-08-05T16:47:01Z
dc.date.available2016-08-08T16:18:38Zen
dc.date.issued2015-07en_US
dc.identifier.citationKotagal, Vikas; Bohnen, Nicolaas I.; Müller, Martijn L.t.m. ; Koeppe, Robert A.; Frey, Kirk A.; Langa, Kenneth M.; Albin, Roger L. (2015). "Educational attainment and motor burden in Parkinson's disease." Movement Disorders 30(8): 1143-1147.en_US
dc.identifier.issn0885-3185en_US
dc.identifier.issn1531-8257en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/112215
dc.description.abstractObjectiveGreater educational attainment is a protective factor for neurodegenerative dementias. If education earlier in life leads to greater cerebral reserve, it may play a similar protective role in Parkinson's disease (PD).MethodsWe conducted a cross‐sectional clinical imaging study of 142 subjects with PD. All subjects underwent [11C]dihydrotetrabenazine PET to confirm nigrostriatal dopaminergic denervation and brain MRI to estimate adjusted cortical gray matter volume (GMV).ResultsAfter adjusting for possible confounders, including cognitive and dopaminergic covariates, as well as nonspecific neurodegeneration covariates (age, disease duration, and total adjusted cortical GMV), lower years of education remained a significant predictor of higher total MDS‐UPDRS motor score (t = −3.28; P = 0.001). Education level associated inversely with white matter (WM) hyperintensities in a post‐hoc analysis (n = 83).ConclusionsHigher educational attainment is associated with lower severity of motor impairment in PD. This association may reflect an extranigral protective effect upon WM integrity.en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherneuroprotectionen_US
dc.subject.otherParkinson's diseaseen_US
dc.subject.othergray matteren_US
dc.subject.othereducationen_US
dc.subject.otherdopamineen_US
dc.titleEducational attainment and motor burden in Parkinson's diseaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/112215/1/mds26272.pdf
dc.identifier.doi10.1002/mds.26272en_US
dc.identifier.sourceMovement Disordersen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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