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Haploinsufficiency of myostatin protects against aging‐related declines in muscle function and enhances the longevity of mice

dc.contributor.authorMendias, Christopher L.en_US
dc.contributor.authorBakhurin, Konstantin I.en_US
dc.contributor.authorGumucio, Jonathan P.en_US
dc.contributor.authorShallal‐ayzin, Mark V.en_US
dc.contributor.authorDavis, Carol S.en_US
dc.contributor.authorFaulkner, John A.en_US
dc.date.accessioned2015-08-05T16:47:10Z
dc.date.available2016-09-06T15:43:59Zen
dc.date.issued2015-08en_US
dc.identifier.citationMendias, Christopher L.; Bakhurin, Konstantin I.; Gumucio, Jonathan P.; Shallal‐ayzin, Mark V. ; Davis, Carol S.; Faulkner, John A. (2015). "Haploinsufficiency of myostatin protects against agingâ related declines in muscle function and enhances the longevity of mice." Aging Cell 14(4): 704-706.en_US
dc.identifier.issn1474-9718en_US
dc.identifier.issn1474-9726en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/112228
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherGDF‐8en_US
dc.subject.othermyostatinen_US
dc.subject.othermuscle contractilityen_US
dc.subject.othermuscle atrophyen_US
dc.subject.otherlongevityen_US
dc.subject.otherskeletal muscleen_US
dc.subject.othersarcopeniaen_US
dc.titleHaploinsufficiency of myostatin protects against aging‐related declines in muscle function and enhances the longevity of miceen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/112228/1/acel12339-sup-0003-TableS1.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/112228/2/acel12339.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/112228/3/acel12339-sup-0004-TableS2.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/112228/4/acel12339-sup-0002-FigureS1.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/112228/5/acel12339-sup-0001-DataS1.pdf
dc.identifier.doi10.1111/acel.12339en_US
dc.identifier.sourceAging Cellen_US
dc.identifier.citedreferenceBish LT, George I, Maybaum S, Yang J, Chen JM, Sweeney HL ( 2011 ) Myostatin is elevated in congenital heart disease and after mechanical unloading. PLoS One 6, e23818.en_US
dc.identifier.citedreferenceLynch GS, Hinkle RT, Chamberlain JS, Brooks SV, Faulkner JA ( 2001 ) Force and power output of fast and slow skeletal muscles from mdx mice 6–28 months old. J. Physiol. (Lond) 535, 591 – 600.en_US
dc.identifier.citedreferenceLakatta EG, Levy D ( 2003 ) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease. Circulation 107, 346 – 354.en_US
dc.identifier.citedreferenceGumucio JP, Mendias CL ( 2013 ) Atrogin‐1, MuRF‐1, and sarcopenia. Endocrine 43, 12 – 21.en_US
dc.identifier.citedreferenceGraber TG, Ferguson‐Stegall L, Kim J‐H, Thompson LV ( 2013 ) C57BL/6 neuromuscular healthspan scoring system. J. Gerontol. A Biol. Sci. Med. Sci. 68, 1326 – 1336.en_US
dc.identifier.citedreferenceFielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan van Kan G, Andrieu S, Bauer J, Breuille D, Cederholm T, Chandler J, De Meynard C, Donini L, Harris T, Kannt A, Keime Guibert F, Onder G, Papanicolaou D, Rolland Y, Rooks D, Sieber C, Souhami E, Verlaan S, Zamboni M ( 2011 ) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J. Am. Med. Dir. Assoc. 12, 249 – 256.en_US
dc.identifier.citedreferenceBrooks SV, Faulkner JA ( 1988 ) Contractile properties of skeletal muscles from young, adult and aged mice. J. Physiol. (Lond) 404, 71 – 82.en_US
dc.identifier.citedreferenceBlagosklonny MV ( 2013 ) Big mice die young but large animals live longer. Aging (Albany NY) 5, 227 – 233.en_US
dc.identifier.citedreferenceRamaswamy KS, Palmer ML, Van der Meulen JH, Renoux A, Kostrominova TY, Michele DE, Faulkner JA ( 2011 ) Lateral transmission of force is impaired in skeletal muscles of dystrophic mice and very old rats. J. Physiol. (Lond) 589, 1195 – 1208.en_US
dc.identifier.citedreferenceMiller MD, Crotty M, Giles LC, Bannerman E, Whitehead C, Cobiac L, Daniels LA, Andrews G ( 2002 ) Corrected arm muscle area: an independent predictor of long‐term mortality in community‐dwelling older adults? J. Am. Geriatr. Soc. 50, 1272 – 1277.en_US
dc.identifier.citedreferenceMendias CL, Bakhurin KI, Faulkner JA ( 2008 ) Tendons of myostatin‐deficient mice are small, brittle, and hypocellular. Proc. Natl Acad. Sci. USA 105, 388 – 393.en_US
dc.identifier.citedreferenceMendias CL, Marcin JE, Calerdon DR, Faulkner JA ( 2006 ) Contractile properties of EDL and soleus muscles of myostatin‐deficient mice. J. Appl. Physiol. 101, 898 – 905.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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