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The role of melano‐macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus)
dc.contributor.authorBarst, Benjamin D.en_US
dc.contributor.authorBridges, Kristinen_US
dc.contributor.authorKorbas, Malgorzataen_US
dc.contributor.authorRoberts, Aaron P.en_US
dc.contributor.authorVan Kirk, Krayen_US
dc.contributor.authorMcNeel, Kevinen_US
dc.contributor.authorDrevnick, Paul E.en_US
dc.date.accessioned2015-08-05T16:47:26Z
dc.date.available2016-09-06T15:43:59Zen
dc.date.issued2015-08en_US
dc.identifier.citationBarst, Benjamin D.; Bridges, Kristin; Korbas, Malgorzata; Roberts, Aaron P.; Van Kirk, Kray; McNeel, Kevin; Drevnick, Paul E. (2015). "The role of melano‐macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus)." Environmental Toxicology and Chemistry 34(8): 1918-1925.en_US
dc.identifier.issn0730-7268en_US
dc.identifier.issn1552-8618en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/112257
dc.description.abstractMelano‐macrophage aggregates, collections of specialized cells of the innate immune system of fish, are considered a general biomarker for contaminant toxicity. To elucidate further the relationship between macrophage aggregates and metals exposure, yelloweye rockfish (Sebastes ruberrimus), a long‐lived species, were sampled from the east and west coasts of Prince of Wales Island, Alaska. Metals concentrations in livers (inorganic Hg, methyl mercury, Se, Ni, Cd, Cu, Zn) and spleens (inorganic Hg and methyl mercury) were determined, as well as their correlations with melano‐macrophage aggregate area. Sections of liver tissue were analyzed by laser ablation‐inductively coupled plasma–mass spectrometry to determine how metals were spatially distributed between hepatocytes and macrophage aggregates. The concentration of inorganic Hg in whole tissue was the best predictor of macrophage area in yelloweye livers and spleens. Macrophage aggregates had higher relative concentrations than most metals compared with the surrounding hepatocytes. However, not all metals were accumulated to the same degree, as evidenced by differences in the ratios of metals in macrophages compared with hepatocytes. Laser ablation data were corroborated with the results of X‐ray synchrotron fluorescence imaging of a yelloweye liver section. Hepatic macrophage aggregates in yelloweye rockfish may play an important role in the detoxification and storage of Hg and other metals. Environ Toxicol Chem 2015;34:1918–1925. © 2015 SETACen_US
dc.publisherLewis Publishersen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherMercuryen_US
dc.subject.otherLA‐ICP‐MSen_US
dc.subject.otherMelano‐macrophage aggregatesen_US
dc.subject.otherMetalsen_US
dc.subject.otherX‐ray fluorescence imagingen_US
dc.titleThe role of melano‐macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus)en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/112257/1/etc3009.pdf
dc.identifier.doi10.1002/etc.3009en_US
dc.identifier.sourceEnvironmental Toxicology and Chemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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