T cell integrin overexpression as a model of murine autoimmunity
dc.contributor.author | Yung, Raymond L | |
dc.contributor.author | Ray, Donna | |
dc.contributor.author | Mo, Ru R | |
dc.contributor.author | Chen, Jun | |
dc.date.accessioned | 2015-08-07T17:26:09Z | |
dc.date.available | 2015-08-07T17:26:09Z | |
dc.date.issued | 2015-08-07 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/112347 | en_US |
dc.description.abstract | Abstract Integrin adhesion molecules have important adhesion and signaling functions. They also play a central role in the pathogenesis of many autoimmune diseases. Over the past few years we have described a T cell adoptive transfer model to investigate the role of T cell integrin adhesion molecules in the development of autoimmunity. This report summarizes the methods we used in establishing this murine model. By treating murine CD4+ T cells with DNA hypomethylating agents and by transfection we were able to test thein vitro effects of integrin overexpression on T cell autoreactive proliferation, cytotoxicity, adhesion and trafficking. Furthermore, we showed that the ability to inducein vivo autoimmunity may be unique to the integrin lymphocyte function associated antigen-1 (LFA-1). | |
dc.title | T cell integrin overexpression as a model of murine autoimmunity | |
dc.type | Article | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/112347/1/12575_2008_Article_51211.pdf | |
dc.identifier.doi | 10.1251/bpo64 | en_US |
dc.language.rfc3066 | en | |
dc.rights.holder | Springer | |
dc.date.updated | 2015-08-07T17:26:09Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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