Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study
dc.contributor.author | Llewellyn, David J | |
dc.contributor.author | Lang, Iain A | |
dc.contributor.author | Matthews, Fiona E | |
dc.contributor.author | Plassman, Brenda L | |
dc.contributor.author | Rogers, Mary A | |
dc.contributor.author | Morgenstern, Lewis B | |
dc.contributor.author | Fisher, Gwenith G | |
dc.contributor.author | Kabeto, Mohammed U | |
dc.contributor.author | Langa, Kenneth M | |
dc.date.accessioned | 2015-08-07T17:32:08Z | |
dc.date.available | 2015-08-07T17:32:08Z | |
dc.date.issued | 2010-06-24 | |
dc.identifier.citation | Alzheimers Res Ther. 2010 Jun 24;2(3):19 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/112505 | en_US |
dc.description.abstract | Abstract Introduction Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein ε4 (APOE) are associated with dementia. Methods A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE ε4 to dementia was modelled using adjusted multivariable logistic regression. Results Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE ε4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE ε4 and stroke (P = 0.001). Conclusions Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE ε4 allele and their interaction are strongly associated with dementia. | |
dc.title | Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study | |
dc.type | Article | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/112505/1/13195_2009_Article_26.pdf | |
dc.identifier.doi | 10.1186/alzrt43 | en_US |
dc.language.rfc3066 | en | |
dc.rights.holder | Llewellyn et al.. | |
dc.date.updated | 2015-08-07T17:32:08Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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