Viral load responses to HAART is an independent predictor of a new AIDS event in late stage HIV infected patients: prospective cohort study
dc.contributor.author | Kazanjian, Powel | |
dc.contributor.author | Wei, Wei | |
dc.contributor.author | Brown, Morton | |
dc.contributor.author | Gandhi, Tejal | |
dc.contributor.author | Amin, Kamal | |
dc.date.accessioned | 2015-08-07T17:43:30Z | |
dc.date.available | 2015-08-07T17:43:30Z | |
dc.date.issued | 2005-10-31 | |
dc.identifier.citation | Journal of Translational Medicine. 2005 Oct 31;3(1):40 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/112776 | en_US |
dc.description.abstract | Abstract Background A sizeable number of HIV-infected patients receiving HAART do not maintain prolonged virologic suppression. We evaluated long-term HIV viral load (VL) responses to HAART as a risk factor for AIDS events (AE) that is independent of CD4 responses. Methods A cohort of patients with pre-therapy CD4 < 200/mm3 who had CD4 and VL measurements for > one year after receiving HAART at a university clinic were prospectively enrolled. Cox proportional multivariate regression model was used to determine whether CD4 and VL responses were independently associated with new AE. Results The patient (N = 214) mean baseline CD4 = 92/mm3, VL = 219,000 c/mL and follow-up duration 42.3 months (range 13–72 months). A new AE occurred in 56 patients; CD4 cell count response to HAART that remained < 200/mm3 throughout the study period was a significant risk factor for new AE (RR = 9.7–12.5; p < 0.001). Similarly, VL responses that remained > 5,000 c/mL during this period was also a significant risk factor (RR = 6.7–12.8; p = 0.001) that was independent of CD4 response adjusted for <> 200/mm3. Conclusion Maintaining adequate long-term virologic responses to HAART provides a clinical benefit independent of CD4 responses. | |
dc.title | Viral load responses to HAART is an independent predictor of a new AIDS event in late stage HIV infected patients: prospective cohort study | |
dc.type | Article | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/112776/1/12967_2005_Article_100.pdf | |
dc.identifier.doi | 10.1186/1479-5876-3-40 | en_US |
dc.language.rfc3066 | en | |
dc.rights.holder | Kazanjian et al. | |
dc.date.updated | 2015-08-07T17:43:30Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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