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Polyion‐Sensitive Polymeric Membrane‐Based Pulstrode as a Potentiometric Detector in Liquid Chromatography
dc.contributor.authorWang, Xueweien_US
dc.contributor.authorBalijepalli, Anant S.en_US
dc.contributor.authorMeyerhoff, Mark E.en_US
dc.date.accessioned2015-09-01T19:30:38Z
dc.date.available2016-09-06T15:43:59Zen
dc.date.issued2015-08en_US
dc.identifier.citationWang, Xuewei; Balijepalli, Anant S.; Meyerhoff, Mark E. (2015). "Polyion‐Sensitive Polymeric Membrane‐Based Pulstrode as a Potentiometric Detector in Liquid Chromatography." Electroanalysis 27(8): 1823-1828.en_US
dc.identifier.issn1040-0397en_US
dc.identifier.issn1521-4109en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/113143
dc.description.abstractPotentiometric polyion‐sensitive polymeric membrane electrodes are capable of detecting a wide variety of polyionic macromolecules. Herein, we utilize this lack of selectivity to report the first application of this sensor technology as a detector in liquid chromatography (LC). A reversible polycation pulstrode based on tridodecylmethylammonium‐dinonylnaphthalene sulfonate doped within a polymeric membrane is employed as the LC detector. Poly‐arginines/protamine mixtures are separated by cation‐exchange/affinity chromatography on an immobilized heparin column, with eluted polycation peptide bands clearly observed via the pulstrode detector. The LC‐pulstrode system is further applied to follow the production of different polycation peptides derived from thermolysin catalyzed protamine digestion.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherLiquid chromatographyen_US
dc.subject.otherDetectoren_US
dc.subject.otherPolyionen_US
dc.subject.otherPotentiometryen_US
dc.subject.otherPulstrodeen_US
dc.titlePolyion‐Sensitive Polymeric Membrane‐Based Pulstrode as a Potentiometric Detector in Liquid Chromatographyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI 48109‐1055, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/113143/1/1823_ftp.pdf
dc.identifier.doi10.1002/elan.201500101en_US
dc.identifier.sourceElectroanalysisen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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