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Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c‐jun amino‐terminal kinase activation and protein adduct formation
dc.contributor.authorGuldiken, Nurdanen_US
dc.contributor.authorZhou, Qinen_US
dc.contributor.authorKucukoglu, Ozlemen_US
dc.contributor.authorRehm, Melanieen_US
dc.contributor.authorLevada, Katerynaen_US
dc.contributor.authorGross, Annikaen_US
dc.contributor.authorKwan, Raymonden_US
dc.contributor.authorJames, Laura P.en_US
dc.contributor.authorTrautwein, Christianen_US
dc.contributor.authorOmary, M. Bishren_US
dc.contributor.authorStrnad, Pavelen_US
dc.date.accessioned2015-09-01T19:30:51Z
dc.date.available2016-10-10T14:50:23Zen
dc.date.issued2015-09en_US
dc.identifier.citationGuldiken, Nurdan; Zhou, Qin; Kucukoglu, Ozlem; Rehm, Melanie; Levada, Kateryna; Gross, Annika; Kwan, Raymond; James, Laura P.; Trautwein, Christian; Omary, M. Bishr; Strnad, Pavel (2015). "Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c‐jun amino‐terminal kinase activation and protein adduct formation." Hepatology 62(3): 876-886.en_US
dc.identifier.issn0270-9139en_US
dc.identifier.issn1527-3350en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/113159
dc.publisherWiley Periodicals, Inc.en_US
dc.titleHuman keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c‐jun amino‐terminal kinase activation and protein adduct formationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/113159/1/hep27891-sup-0001-suppinfo.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/113159/2/hep27891.pdf
dc.identifier.doi10.1002/hep.27891en_US
dc.identifier.sourceHepatologyen_US
dc.identifier.citedreferenceNelson SD, Forte AJ, McMurtry RJ. Decreased toxicity of the N‐methyl analogs of acetaminophen and phenacetin. Res Commun Chem Pathol Pharmacol 1978; 22: 61 ‐ 71.en_US
dc.identifier.citedreferenceKu NO, Gish R, Wright TL, Omary MB. Keratin 8 mutations in patients with cryptogenic liver disease. N Engl J Med 2001; 344: 1580 ‐ 1587.en_US
dc.identifier.citedreferenceSnider NT, Omary MB. Post‐translational modifications of intermediate filament proteins: mechanisms and functions. Nat Rev Mol Cell Biol 2014; 15: 163 ‐ 177.en_US
dc.identifier.citedreferenceKu NO, Omary MB. A disease‐ and phosphorylation‐related nonmechanical function for keratin 8. J Cell Biol 2006; 174: 115 ‐ 125.en_US
dc.identifier.citedreferenceKrauss S, Franke WW. Organization and sequence of the human gene encoding cytokeratin 8. Gene 1990; 86: 241 ‐ 249.en_US
dc.identifier.citedreferenceMagin TM, Schroder R, Leitgeb S, Wanninger F, Zatloukal K, Grund C, Melton DW. Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver‐specific keratin 8‐positive aggregates. J Cell Biol 1998; 140: 1441 ‐ 1451.en_US
dc.identifier.citedreferenceNakamichi I, Toivola DM, Strnad P, Michie SA, Oshima RG, Baribault H, Omary MB. Keratin 8 overexpression promotes mouse Mallory body formation. J Cell Biol 2005; 171: 931 ‐ 937.en_US
dc.identifier.citedreferenceAksoy S, Szumlanski CL, Weinshilboum RM. Human liver nicotinamide N‐methyltransferase. cDNA cloning, expression, and biochemical characterization. J Biol Chem 1994; 269: 14835 ‐ 14840.en_US
dc.identifier.citedreferenceZhong B, Strnad P, Selmi C, Invernizzi P, Tao GZ, Caleffi A, et al. Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity. Hepatology 2009; 50: 546 ‐ 554.en_US
dc.identifier.citedreferenceCoulombe PA, Lee CH. Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. J Invest Dermatol 2012; 132: 763 ‐ 775.en_US
dc.identifier.citedreferenceSeki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 2012; 143: 307 ‐ 320.en_US
dc.identifier.citedreferenceD'Alessandro M, Russell D, Morley SM, Davies AM, Lane EB. Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock. J Cell Sci 2002; 115: 4341 ‐ 4351.en_US
dc.identifier.citedreferenceSantos M, Perez P, Segrelles C, Ruiz S, Jorcano JL, Paramio JM. Impaired NF‐kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. J Biol Chem 2003; 278: 13422 ‐ 13430.en_US
dc.identifier.citedreferenceTao GZ, Nakamichi I, Ku NO, Wang J, Frolkis M, Gong X, et al. Bispecific and human disease‐related anti‐keratin rabbit monoclonal antibodies. Exp Cell Res 2006; 312: 411 ‐ 422.en_US
dc.identifier.citedreferenceKu NO, Lim JK, Krams SM, Esquivel CO, Keeffe EB, Wright TL, et al. Keratins as susceptibility genes for end‐stage liver disease. Gastroenterology 2005; 129: 885 ‐ 893.en_US
dc.identifier.citedreferenceChung BM, Rotty JD, Coulombe PA. Networking galore: intermediate filaments and cell migration. Curr Opin Cell Biol 2013; 25: 600 – 612.en_US
dc.identifier.citedreferenceLackner C, Gogg‐Kamerer M, Zatloukal K, Stumptner C, Brunt EM, Denk H. Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis. J Hepatol 2008; 48: 821 ‐ 828.en_US
dc.identifier.citedreferenceZhou Q, Ji X, Chen L, Greenberg HB, Lu SC, Omary MB. Keratin mutation primes mouse liver to oxidative injury. Hepatology 2005; 41: 517 ‐ 525.en_US
dc.identifier.citedreferenceTao GZ, Looi KS, Toivola DM, Strnad P, Zhou Q, Liao J, et al. Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis. J Cell Sci 2009; 122: 3851 ‐ 3855.en_US
dc.identifier.citedreferenceKu NO, Soetikno RM, Omary MB. Keratin mutation in transgenic mice predisposes to Fas but not TNF‐induced apoptosis and massive liver injury. HEPATOLOGY 2003; 37: 1006 ‐ 1014.en_US
dc.identifier.citedreferenceStrnad P, Tao GZ, Zhou Q, Harada M, Toivola DM, Brunt EM, Omary MB. Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models. Gastroenterology 2008; 134: 1169 ‐ 1179.en_US
dc.identifier.citedreferenceStrnad P, Lienau TC, Tao GZ, Ku NO, Magin TM, Omary MB. Denaturing temperature selection may underestimate keratin mutation detection by DHPLC. Hum Mutat 2006; 27: 444 ‐ 452.en_US
dc.identifier.citedreferenceStrnad P, Kucukoglu O, Lunova M, Guldiken N, Lienau TC, Stickel F, Omary MB. Non‐coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis. PLoS One 2012; 7: e32669.en_US
dc.identifier.citedreferenceBernal W, Auzinger G, Dhawan A, Wendon J. Acute liver failure. Lancet 2010; 376: 190 ‐ 201.en_US
dc.identifier.citedreferenceFontana RJ. Pathogenesis of idiosyncratic drug‐induced liver injury and clinical perspectives. Gastroenterology 2014; 146: 914 ‐ 928.en_US
dc.identifier.citedreferenceZhao L, Pickering G. Paracetamol metabolism and related genetic differences. Drug Metab Rev 2011; 43: 41 ‐ 52.en_US
dc.identifier.citedreferenceJaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug‐induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev 2012; 44: 88 ‐ 106.en_US
dc.identifier.citedreferenceWatkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA 2006; 296: 87 ‐ 93.en_US
dc.identifier.citedreferenceStrnad P, Zhou Q, Hanada S, Lazzeroni LC, Zhong BH, So P, et al. Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Gastroenterology 2010; 139: 828 ‐ 835, 835.e1‐3.en_US
dc.identifier.citedreferenceHaines RL, Lane EB. Keratins and disease at a glance. J Cell Sci 2012; 125: 3923 ‐ 3928.en_US
dc.identifier.citedreferencePan X, Hobbs RP, Coulombe PA. The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol 2013; 25: 47 ‐ 56.en_US
dc.identifier.citedreferenceSzeverenyi I, Cassidy AJ, Chung CW, Lee BT, Common JE, Ogg SC, et al. The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases. Hum Mutat 2008; 29: 351 ‐ 360.en_US
dc.identifier.citedreferenceOmary MB, Ku NO, Strnad P, Hanada S. Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest 2009; 119: 1794 ‐ 1805.en_US
dc.identifier.citedreferenceStrnad P, Paschke S, Jang KH, Ku NO. Keratins: markers and modulators of liver disease. Curr Opin Gastroenterol 2012; 28: 209 ‐ 216.en_US
dc.identifier.citedreferenceKu N, Strnad P, Zhong BH, Tao GZ, Omary MB. Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory‐Denk bodies. Hepatology 2007; 46: 1639 ‐ 1649.en_US
dc.identifier.citedreferenceTao GZ, Strnad P, Zhou Q, Kamal A, Zhang L, Madani ND, et al. Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. Clin Gastroenterol Hepatol 2007; 5: 857 ‐ 864.en_US
dc.identifier.citedreferenceStrnad P, Usachov V, Debes C, Grater F, Parry DA, Omary MB. Unique amino acid signatures that are evolutionarily conserved distinguish simple‐type, epidermal and hair keratins. J Cell Sci 2011; 124: 4221 ‐ 4232.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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