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Epigenetic Control of PACE4 Gene Expression Associated with Metastasis
dc.contributor.authorSura, Rishin
dc.contributor.advisorMilitante, Julius
dc.date.accessioned2016-05-09T16:29:15Z
dc.date.available2016-05-09T16:29:15Z
dc.date.issued2013-04-01
dc.identifier.urihttps://hdl.handle.net/2027.42/117929
dc.description.abstractThe main purpose of the project is to study the epigenetic change in the PACE4 gene as it is related to stressors that induce PC-associated metastasis and in doing so, provide an explanation for the stable cellular changes that result in metastasis. The specific objectives of the project are: 1. To evaluate the methylation status of the promoter region of the PACE4 gene in LoVo cells under normal growth conditions, and 2. To describe possible changes in DNA methylation of the PACE 4 gene under conditions of hypoxia, hyperthermia, alone and in combination.
dc.subjectPACE4 gene
dc.subjectmetastasis
dc.subjectstressors
dc.titleEpigenetic Control of PACE4 Gene Expression Associated with Metastasis
dc.typeThesis
dc.description.thesisdegreenameMaster's
dc.description.thesisdegreedisciplineCollege of Arts and Sciences: Biology
dc.description.thesisdegreegrantorUniversity of Michigan
dc.contributor.committeememberMilitante, Julius
dc.contributor.committeememberSucic, Joesph F.
dc.contributor.committeememberMiskevich, Frank
dc.contributor.affiliationumcampusFlint
dc.identifier.uniqname68886215
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/117929/1/Sura.pdf
dc.owningcollnameDissertations and Theses (Ph.D. and Master's)


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