Effect of micronization on the extent of drug absorption from suspensions in humans
dc.contributor.author | Oh, Doo Man | |
dc.contributor.author | Amidon, G. L. | |
dc.contributor.author | Curl, Rane L | |
dc.contributor.author | Yong, ChuI-Soon | |
dc.date.accessioned | 2016-08-02T22:20:00Z | |
dc.date.available | 2016-08-02T22:20:00Z | |
dc.date.issued | 1995 | |
dc.identifier.citation | Archive of Pharmacal Research, Vol. 18, No. 6, 1995, pp. 427-433 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/122837 | |
dc.description.abstract | A microscopic mass balance approach has shown that the initial saturation (Is), absorption number (An), dose number (Do), and dissolution number (Dn) are four fundamental dimensionless parameters that can be used to estimate the fraction dose absorbed (~ of suspensions of poorly soluble drugs in humans. The dissolution number of a drug increases with decreasing its particle size. The effect of micronization on F for suspensions was investigated in terms of Dn. About 90% of maximal Fcan be achieved at Dn-~2. Increasing the solubility of a drug results in better oral absorption through increasing Dn and decreasing Do. The fractions dose absorbed of digoxin, griseofulvin, and benoxaprofen agree with predicted F values using estimated parameters. Drugs with low Do and low Dn can be more completely absorbed by reducing particle size, while absorption of drugs with high Do and low Dn is limited by solubility and requires higher solubility to enhance the fraction dose absorbed in addition to micronization. Solubility at the physiological pH should be used for the estimation of the fraction dose absorbed. | en_US |
dc.description.sponsorship | NIGMS Grant GM 37188. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Springer | en_US |
dc.subject | Drug Dose Micronization Absorption | en_US |
dc.title | Effect of micronization on the extent of drug absorption from suspensions in humans | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | |
dc.subject.hlbtoplevel | Engineering | |
dc.contributor.affiliationum | Chemical Engineering, Department of | en_US |
dc.contributor.affiliationum | College of Pharmacy, | en_US |
dc.contributor.affiliationother | College of Pharmacy, Catholic University of Taegu-Hyosung, Kyungsan, Kyungbuk 713-702, Korea, | en_US |
dc.contributor.affiliationother | College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/122837/1/Oh(1995)Micronization.pdf | |
dc.identifier.source | Archive of Pharmacal Research | en_US |
dc.description.filedescription | Description of Oh(1995)Micronization.pdf : Main article | |
dc.owningcollname | Chemical Engineering (ChE) |
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