Nonlinear times series analysis of epileptic human electroencephalogram (EEG).
dc.contributor.author | Li, Dingzhou | |
dc.contributor.advisor | Savit, Robert | |
dc.date.accessioned | 2016-08-30T15:53:22Z | |
dc.date.available | 2016-08-30T15:53:22Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3192560 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/125277 | |
dc.description.abstract | The problem of seizure anticipation in patients with epilepsy has attracted significant attention in the past few years. In this paper we discuss two approaches, using methods of nonlinear time series analysis applied to scalp electrode recordings, which is able to distinguish between epochs temporally distant from and just prior to, the onset of a seizure in patients with temporal lobe epilepsy. First we describe a method involving a comparison of recordings taken from electrodes adjacent to and remote from the site of the seizure focus. In particular, we define a nonlinear quantity which we call marginal predictability. This quantity is computed using data from remote and from adjacent electrodes. We find that the difference between the marginal predictabilities computed for the remote and adjacent electrodes decreases several tens of minutes prior to seizure onset, compared to its value interictally. We also show that these difl'crcnc es of marginal predictability intervals are independent of the behavior state of the patient. Next we examine the please coherence between different electrodes both in the long-range and the short-range. When time is distant from seizure onsets (interictally), epileptic patients have lower long-range phase coherence in the delta (1-4Hz) and beta (18-30Hz) frequency band compared to nonepileptic subjects. When seizures approach (''preictally), we observe an increase in phase coherence in the beta band. However, interictally there is no difference in short-range phase coherence between this cohort of patients and non-epileptic subjects. Preictally short-range phase coherence also increases in the alpha (10-13Hz) and the beta band. Next we apply the quantity marginal predictability on the phase difference time series. Such marginal predictabilities are lower in the patients than in the non-epileptic subjects. However, when seizure approaches, the former moves asymptotically towards the latter. | |
dc.format.extent | 67 p. | |
dc.language | English | |
dc.language.iso | EN | |
dc.subject | Analysis | |
dc.subject | Eeg | |
dc.subject | Electroencephalogram | |
dc.subject | Epileptic | |
dc.subject | Human | |
dc.subject | Nonlinear Time Series | |
dc.subject | Preictal | |
dc.subject | Times | |
dc.title | Nonlinear times series analysis of epileptic human electroencephalogram (EEG). | |
dc.type | Thesis | |
dc.description.thesisdegreename | PhD | en_US |
dc.description.thesisdegreediscipline | Biological Sciences | |
dc.description.thesisdegreediscipline | Biophysics | |
dc.description.thesisdegreediscipline | Health and Environmental Sciences | |
dc.description.thesisdegreediscipline | Medical imaging | |
dc.description.thesisdegreediscipline | Physics | |
dc.description.thesisdegreediscipline | Pure Sciences | |
dc.description.thesisdegreegrantor | University of Michigan, Horace H. Rackham School of Graduate Studies | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/125277/2/3192560.pdf | |
dc.owningcollname | Dissertations and Theses (Ph.D. and Master's) |
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