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Periodontal health in breast cancer patients on aromatase inhibitors versus postmenopausal controls: a longitudinal analysis
dc.contributor.authorEagle, Iwonka
dc.contributor.authorBenavides, Erika
dc.contributor.authorEber, Robert
dc.contributor.authorKolenic, Giselle
dc.contributor.authorJung, Younghun
dc.contributor.authorVan Poznak, Catherine
dc.contributor.authorTaichman, L. Susan
dc.date.accessioned2016-09-17T23:53:52Z
dc.date.available2017-11-01T15:31:29Zen
dc.date.issued2016-08
dc.identifier.citationEagle, Iwonka; Benavides, Erika; Eber, Robert; Kolenic, Giselle; Jung, Younghun; Van Poznak, Catherine; Taichman, L. Susan (2016). "Periodontal health in breast cancer patients on aromatase inhibitors versus postmenopausal controls: a longitudinal analysis." Journal of Clinical Periodontology 43(8): 659-667.
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.urihttps://hdl.handle.net/2027.42/133559
dc.description.abstractAimThis study was conducted to determine periodontal changes in postmenopausal breast cancer (BCa) survivors using aromatase inhibitors (AI) as compared to postmenopausal women without BCa.MethodsAn 18‐month prospective examination of periodontal health in postmenopausal women (29 receiving AI therapy; 29 women without BCa) was conducted at University of Michigan. Comprehensive periodontal examinations including alveolar bone height (ABH) were conducted at baseline, 6, 12, and 18 months. Bisphosphonate, vitamin D, and calcium supplementation were collected via chart review. Linear mixed models were utilized to investigate the relationship between AI and periodontal measures.ResultsAromatase inhibitor users had significantly deeper probing depths, more dental plaque and clinical attachment loss as compared to controls at the 6, 12, and 18 month study visits (p < 0.05). ABH loss was seen over time within the AI group. The linear mixed model showed a significant effect of time as well as an interaction between aromatase inhibitor use and calcium supplement status. AI users taking calcium experienced less ABH loss over the study than AI users not taking calcium (p = 0.005).ConclusionAromatase inhibitor therapy has a negative impact on the periodontal health of postmenopausal BCa patients. Calcium supplementation appears to mitigate ABH loss in women on AI.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherpostmenopause
dc.subject.otheraromatase inhibitors
dc.subject.otherbiological markers
dc.subject.otherbreast neoplasms
dc.subject.otherperiodontal attachment loss
dc.subject.otherwomen health
dc.titlePeriodontal health in breast cancer patients on aromatase inhibitors versus postmenopausal controls: a longitudinal analysis
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/133559/1/jcpe12562_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/133559/2/jcpe12562.pdf
dc.identifier.doi10.1111/jcpe.12562
dc.identifier.sourceJournal of Clinical Periodontology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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