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Neurologic late effects associated with radiologic evidence of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome associated with survivors of laryngeal and hypopharyngeal cancer
dc.contributor.authorRosko, Andrew J.
dc.contributor.authorSpector, Matthew E.
dc.contributor.authorGriffin, Garrett R.
dc.contributor.authorVainshtein, Jeffrey M.
dc.contributor.authorLee, Jae
dc.contributor.authorBradford, Carol R.
dc.contributor.authorPrince, Mark E. P.
dc.contributor.authorMoyer, Jeffrey S.
dc.contributor.authorWorden, Francis P.
dc.contributor.authorEisbruch, Avraham
dc.contributor.authorChepeha, Douglas B.
dc.date.accessioned2016-09-17T23:54:05Z
dc.date.available2017-11-01T15:31:29Zen
dc.date.issued2016-08
dc.identifier.citationRosko, Andrew J.; Spector, Matthew E.; Griffin, Garrett R.; Vainshtein, Jeffrey M.; Lee, Jae; Bradford, Carol R.; Prince, Mark E. P.; Moyer, Jeffrey S.; Worden, Francis P.; Eisbruch, Avraham; Chepeha, Douglas B. (2016). "Neurologic late effects associated with radiologic evidence of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome associated with survivors of laryngeal and hypopharyngeal cancer." Head & Neck 38(8): 1187-1193.
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.urihttps://hdl.handle.net/2027.42/133568
dc.description.abstractBackgroundDelayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection.MethodsWe conducted a retrospective case series of 6 patients presenting from 2003 to 2012 with a history of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) followed by salvage laryngectomy.ResultsPosterior neck and upper back pain developed a mean of 27.5 days after instrumentation of the pharynx (reconstruction after laryngectomy or pharyngeal dilation). Myelopathy developed an average of 21.5 days after the onset of posterior neck pain. Five patients required urgent decompression. Three patients developed quadriplegia. The disease‐specific mortality was 50%.ConclusionThere is a syndrome of late neurological effects after RT, salvage surgery, and pharyngeal instrumentation that is associated with high morbidity and mortality. © 2016 Wiley Periodicals, Inc. Head Neck 38:1187–1193, 2016
dc.publisherWiley Periodicals, Inc.
dc.subject.otherhead and neck cancer
dc.subject.othersalvage laryngectomy
dc.subject.otherlate effects
dc.subject.otherosteoradionecrosis
dc.subject.othermyelopathy
dc.titleNeurologic late effects associated with radiologic evidence of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome associated with survivors of laryngeal and hypopharyngeal cancer
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/133568/1/hed24348_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/133568/2/hed24348.pdf
dc.identifier.doi10.1002/hed.24348
dc.identifier.sourceHead & Neck
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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