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Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and metaâ analysis
dc.contributor.authorLin, Guo‐hao
dc.contributor.authorLim, Glendale
dc.contributor.authorChan, Hsun‐liang
dc.contributor.authorGiannobile, William V.
dc.contributor.authorWang, Hom‐lay
dc.date.accessioned2016-11-18T21:23:48Z
dc.date.available2018-01-08T19:47:52Zen
dc.date.issued2016-11
dc.identifier.citationLin, Guo‐hao ; Lim, Glendale; Chan, Hsun‐liang ; Giannobile, William V.; Wang, Hom‐lay (2016). "Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and metaâ analysis." Clinical Oral Implants Research 27(11): 1349-1359.
dc.identifier.issn0905-7161
dc.identifier.issn1600-0501
dc.identifier.urihttps://hdl.handle.net/2027.42/134457
dc.description.abstractAimsTo study the effect of the recombinant human bone morphogenetic protein 2 (rhBMPâ 2) on sinus volumetric and histometric changes after sinus floor augmentation compared to a conventional approach of nonâ biologic bone grafting materials.Materials and methodsAn electronic search of 4 databases (January 1990â February 2015), including PubMed/MEDLINE, EMBASE, Web of Science and Cochrane Central, and a hand search of peerâ reviewed journals for relevant articles were performed. Human clinical trials with data on comparison of sinus volumetric and/or histometric outcomes with and without the use of rhBMPâ 2 in sinus grafting procedures, with â ¥10 augmentation sites in each study group, and with a followâ up period of at least 6 months, were included. Randomâ effects metaâ analyses were performed to analyze weighted mean difference (WMD) and confidence interval (CI) for the recorded variables according to PRISMA guidelines.ResultsSix randomized controlled trials (RCTs) were included. The results of the metaâ analyses showed that the WMD of vertical bone height gain was â 0.14 mm (95% CI = â 1.91 to 1.62 mm, P = 0.87), the WMD of bone density was â 142.42 mg/cm3 (95% CI = â 310.62â 25.78 mg/cm3, P = 0.10), the WMD of the percentage of vital bone was â 4.59% (95% CI = â 11.73â 2.56%, P = 0.21), and the WMD of the percentage of residual bone grafting materials was â 9.90% (95% CI = â 26.38â 6.58%, P = 0.21). The comparison of implant survival rate presented an overall risk ratio of 1.00 (95% CI = 0.94â 1.07). The two approaches (conventional bone grafting compared to BMPs) demonstrated comparable effectiveness for both clinical and histomorphometric measures.ConclusionsThis systematic review revealed that the use of rhBMPâ 2 in maxillary sinus floor augmentation achieved similar clinical and histometric outcomes when compared to conventional sinus grafting procedures after a healing period of 6â 9 months. However, previous studies showed the morbidity and other patientâ reported outcomes were improved in rhBMPâ 2 approaches as compared to bone autograft procedures (both intraoral and extraoral bone harvesting because no donor site is required). Longâ term studies are required to determine the costâ benefit of sinus floor augmentation procedures for patients requiring implant reconstruction.
dc.publisherWiley Periodicals, Inc.
dc.subject.othergrowth factors
dc.subject.othermorphometric analysis
dc.subject.othersinus floor elevation
dc.subject.otherwound healing
dc.subject.otherbone substitutes
dc.titleRecombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and metaâ analysis
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/134457/1/clr12737.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/134457/2/clr12737_am.pdf
dc.identifier.doi10.1111/clr.12737
dc.identifier.sourceClinical Oral Implants Research
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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