View Item 

Show simple item record

Targeting the Notch Pathway to Prevent Rejection
dc.contributor.authorChung, J.
dc.contributor.authorRiella, L. V.
dc.contributor.authorMaillard, I.
dc.date.accessioned2016-11-18T21:23:59Z
dc.date.available2018-01-08T19:47:52Zen
dc.date.issued2016-11
dc.identifier.citationChung, J.; Riella, L. V.; Maillard, I. (2016). "Targeting the Notch Pathway to Prevent Rejection." American Journal of Transplantation 16(11): 3079-3085.
dc.identifier.issn1600-6135
dc.identifier.issn1600-6143
dc.identifier.urihttps://hdl.handle.net/2027.42/134466
dc.publisherWiley Periodicals, Inc.
dc.subject.otherrejection: T cell mediated (TCMR)
dc.subject.otherrejection: antibodymediated (ABMR)
dc.subject.otherheart (allograft) function/dysfunction
dc.subject.othergraft‐versus‐host disease (GVHD)
dc.subject.otherbasic (laboratory) research/science
dc.subject.othertranslational research/science
dc.subject.otherbone marrow/hematopoietic stem cell transplantation
dc.subject.otherimmunosuppression/immune modulation
dc.subject.otherheart transplantation/cardiology
dc.subject.otherT cell biology
dc.titleTargeting the Notch Pathway to Prevent Rejection
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/134466/1/ajt13816_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/134466/2/ajt13816.pdf
dc.identifier.doi10.1111/ajt.13816
dc.identifier.sourceAmerican Journal of Transplantation
dc.identifier.citedreferenceSchaller MA, Neupane R, Rudd BD, et al. Notch ligand Delta‐like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J Exp Med 2007; 204: 2925 – 2934.
dc.identifier.citedreferenceWang H, Zou J, Zhao B, et al. Genome‐wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T‐lymphoblastic leukemia cells. Proc Natl Acad Sci U S A 2011; 108: 14908 – 14913.
dc.identifier.citedreferenceWang H, Zang C, Taing L, et al. NOTCH1‐RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A 2014; 111: 705 – 710.
dc.identifier.citedreferenceCalderon L, Boehm T. Synergistic, context‐dependent, and hierarchical functions of epithelial components in thymic microenvironments. Cell 2012; 149: 159 – 172.
dc.identifier.citedreferenceFasnacht N, Huang HY, Koch U, et al. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch‐regulated immune responses. J Exp Med 2014; 211: 2265 – 2279.
dc.identifier.citedreferenceAmsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen‐presenting cells. Cell 2004; 117: 515 – 526.
dc.identifier.citedreferenceRidgway J, Zhang G, Wu Y, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006; 444: 1083 – 1087.
dc.identifier.citedreferenceWu Y, Cain‐Hom C, Choy L, et al. Therapeutic antibody targeting of individual Notch receptors. Nature 2010; 464: 1052 – 1057.
dc.identifier.citedreferenceHoyne GF, Le Roux I, Corsin‐Jimenez M, et al. Serrate1‐induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int Immunol 2000; 12: 177 – 185.
dc.identifier.citedreferenceVigouroux S, Yvon E, Wagner HJ, et al. Induction of antigen‐specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol 2003; 77: 10872 – 10880.
dc.identifier.citedreferenceYvon ES, Vigouroux S, Rousseau RF, et al. Overexpression of the Notch ligand, Jagged‐1, induces alloantigen‐specific human regulatory T cells. Blood 2003; 102: 3815 – 3821.
dc.identifier.citedreferenceWong KK, Carpenter MJ, Young LL, et al. Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell‐dependent mechanism. J Clin Invest 2003; 112: 1741 – 1750.
dc.identifier.citedreferenceLin Y, Chen W, Li J, et al. Overexpression of Jagged‐1 combined with blockade of CD40 pathway prolongs allograft survival. Immunol Cell Biol 2015; 93: 213 – 217.
dc.identifier.citedreferenceMaekawa Y, Tsukumo S, Chiba S, et al. Delta1‐Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 2003; 19: 549 – 559.
dc.identifier.citedreferenceOng CT, Sedy JR, Murphy KM, Kopan R. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS ONE 2008; 3: e2823.
dc.identifier.citedreferenceHelbig C, Gentek R, Backer RA, et al. Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proc Natl Acad Sci U S A 2012; 109: 9041 – 9046.
dc.identifier.citedreferenceBailis W, Yashiro‐Ohtani Y, Fang TC, et al. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity 2013; 39: 148 – 159.
dc.identifier.citedreferenceLaky K, Evans S, Perez‐Diez A, Fowlkes BJ. Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co‐stimulation. Immunity 2015; 42: 80 – 94.
dc.identifier.citedreferenceTu L, Fang TC, Artis D, et al. Notch signaling is an important regulator of type 2 immunity. J Exp Med 2005; 202: 1037 – 1042.
dc.identifier.citedreferenceElyaman W, Bassil R, Bradshaw EM, et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin‐9‐producing T cells. Immunity 2012; 36: 623 – 634.
dc.identifier.citedreferenceBacker RA, Helbig C, Gentek R, et al. A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol 2014; 15: 1143 – 1151.
dc.identifier.citedreferenceMaekawa Y, Ishifune C, Tsukumo S, Hozumi K, Yagita H, Yasutomo K. Notch controls the survival of memory CD4+ T cells by regulating glucose uptake. Nat Med 2015; 21: 55 – 61.
dc.identifier.citedreferenceMathieu M, Duval F, Daudelin JF, Labrecque N. The Notch signaling pathway controls short‐lived effector CD8+ T cell differentiation but is dispensable for memory generation. J Immunol 2015; 194: 5654 – 5662.
dc.identifier.citedreferenceSandy AR, Stoolman J, Malott K, Pongtornpipat P, Segal BM, Maillard I. Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis. J Immunol 2013; 191: 1606 – 1613.
dc.identifier.citedreferenceBilliard F, Lobry C, Darrasse‐Jeze G, et al. Dll4‐Notch signaling in Flt3‐independent dendritic cell development and autoimmunity in mice. J Exp Med 2012; 209: 1011 – 1028.
dc.identifier.citedreferenceKopan R, Ilagan MX. The canonical Notch signaling pathway: Unfolding the activation mechanism. Cell 2009; 137: 216 – 233.
dc.identifier.citedreferenceGuruharsha KG, Kankel MW, Artavanis‐Tsakonas S. The Notch signalling system: Recent insights into the complexity of a conserved pathway. Nat Rev Genet 2012; 13: 654 – 666.
dc.identifier.citedreferenceRadtke F, MacDonald HR, Tacchini‐Cottier F. Regulation of innate and adaptive immunity by Notch. Nat Rev Immunol 2013; 13: 427 – 437.
dc.identifier.citedreferenceAmsen D, Helbig C, Backer RA. Notch in T cell differentiation: All things considered. Trends Immunol 2015; 36: 802 – 814.
dc.identifier.citedreferenceOsborne BA, Minter LM. Notch signalling during peripheral T‐cell activation and differentiation. Nat Rev Immunol 2007; 7: 64 – 75.
dc.identifier.citedreferenceZhang Y, Sandy AR, Wang J, et al. Notch signaling is a critical regulator of allogeneic CD4+ T‐cell responses mediating graft‐versus‐host disease. Blood 2011; 117: 299 – 308.
dc.identifier.citedreferenceTran IT, Sandy AR, Carulli AJ, et al. Blockade of individual Notch ligands and receptors controls graft‐versus‐host disease. J Clin Invest 2013; 123: 1590 – 1604.
dc.identifier.citedreferenceSandy AR, Chung J, Toubai T, et al. T cell‐specific notch inhibition blocks graft‐versus‐host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells. J Immunol 2013; 190: 5818 – 5828.
dc.identifier.citedreferenceRiella LV, Ueno T, Batal I, et al. Blockade of Notch ligand delta1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation. J Immunol 2011; 187: 4629 – 4638.
dc.identifier.citedreferenceRiella LV, Yang J, Chock S, et al. Jagged2‐signaling promotes IL‐6‐dependent transplant rejection. Eur J Immunol 2013; 43: 1449 – 1458.
dc.identifier.citedreferenceRoderick JE, Gonzalez‐Perez G, Kuksin CA, et al. Therapeutic targeting of NOTCH signaling ameliorates immune‐mediated bone marrow failure of aplastic anemia. J Exp Med 2013; 210: 1311 – 1329.
dc.identifier.citedreferenceMochizuki K, Xie F, He S, et al. Delta‐like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice. J Immunol 2013; 190: 3772 – 3782.
dc.identifier.citedreferenceCharbonnier LM, Wang S, Georgiev P, Sefik E, Chatila TA. Control of peripheral tolerance by regulatory T cell‐intrinsic Notch signaling. Nat Immunol 2015; 16: 1162 – 1173.
dc.identifier.citedreferenceWood S, Feng J, Chung J, et al. Transient blockade of delta‐like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation. J Immunol 2015; 194: 2899 – 2908.
dc.identifier.citedreferenceMaillard I, Weng AP, Carpenter AC, et al. Mastermind critically regulates Notch‐mediated lymphoid cell fate decisions. Blood 2004; 104: 1696 – 1702.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
ajt13816_am.pdf
Size:
210.6KB
Format:
PDF
View/Open
Name:
ajt13816.pdf
Size:
216.2KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.