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Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination

dc.contributor.authorIrani, David N.
dc.date.accessioned2017-04-13T20:35:11Z
dc.date.available2018-05-04T20:56:58Zen
dc.date.issued2017-02
dc.identifier.citationIrani, David N. (2017). "Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination." Annals of Clinical and Translational Neurology 4(2): 145-150.
dc.identifier.issn2328-9503
dc.identifier.issn2328-9503
dc.identifier.urihttps://hdl.handle.net/2027.42/136295
dc.description.abstractOxidative damage occurs in multiple sclerosis, but is difficult to identify antemortem and remains an unknown contributor to disease progression. Carbonylation is a quantitative measure of protein oxidation. Cerebrospinal fluid samples from multiple sclerosis patients showed elevated carbonylated protein levels compared to controls. In experimental autoimmune encephalomyelitis, carbonylated protein levels in cerebrospinal fluid correlated tightly with those found in inflamed spinal cord tissues. Furthermore, concentrations in cerebrospinal fluid and spinal cord responded in parallel to an antioxidant intervention that also attenuated disease symptoms. These data suggest that carbonylated cerebrospinal fluid proteins could be a quantitative, sensitive, and disease‐relevant biomarker in multiple sclerosis.
dc.publisherWiley Periodicals, Inc.
dc.publisherSaunders/Elsevier
dc.titleCerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurology and Neurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/136295/1/acn3379_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/136295/2/acn3379.pdf
dc.identifier.doi10.1002/acn3.379
dc.identifier.sourceAnnals of Clinical and Translational Neurology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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