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Positron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer
dc.contributor.authorRosko, Andrew
dc.contributor.authorBirkeland, Andrew
dc.contributor.authorShuman, Andrew
dc.contributor.authorPrince, Mark
dc.contributor.authorBradford, Carol
dc.contributor.authorWolf, Gregory
dc.contributor.authorWorden, Francis
dc.contributor.authorEisbruch, Avraham
dc.contributor.authorSrinivasan, Ashok
dc.contributor.authorWong, Ka Kit
dc.contributor.authorSpector, Matthew E.
dc.date.accessioned2017-05-10T17:47:46Z
dc.date.available2018-07-09T17:42:24Zen
dc.date.issued2017-05
dc.identifier.citationRosko, Andrew; Birkeland, Andrew; Shuman, Andrew; Prince, Mark; Bradford, Carol; Wolf, Gregory; Worden, Francis; Eisbruch, Avraham; Srinivasan, Ashok; Wong, Ka Kit; Spector, Matthew E. (2017). "Positron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer." Head & Neck 39(5): 980-987.
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.urihttps://hdl.handle.net/2027.42/136682
dc.description.abstractBackgroundThe purpose of this study was to evaluate the predictive value of positron emission tomography (PET)‐CT in identifying occult nodal metastasis in clinically and radiographically N0 patients with recurrent laryngeal cancer undergoing salvage laryngectomy.MethodsRetrospective review of 46 clinically and radiographically N0 patients with recurrent laryngeal cancer who underwent a PET‐CT examination before salvage laryngectomy with neck dissection from January 1, 2002, to December 31, 2014, was performed.ResultsTwo patients (16.7%) had true‐positive PET‐CT results, whereas 10 patients (83.3%) had false‐negative scans, 1 patient (2.9%) had a false‐positive result and 33 patients (97.1%) had a true‐negative PET‐CT. The sensitivity of PET‐CT was 16.7% (95% confidence interval [CI], 3.5% to 46.0%) with a specificity of 97.1% (95% CI, 83.8% to 99.9%), positive predictive value (PPV) of 66.7% (95% CI, 20.2% to 94.4%), and negative predictive value (NPV) of 76.7% (95% CI, 62.1% to 87.0%).ConclusionPET‐CT has poor sensitivity and NPV making PET‐CT an imperfect predictor of nodal disease in recurrent laryngeal cancer. © 2017 Wiley Periodicals, Inc. Head Neck 39: 980–987, 2017
dc.publisherWiley Periodicals, Inc.
dc.subject.otherpositron emission tomography (PET)‐CT
dc.subject.otheroccult nodal metastasis
dc.subject.otherrecurrent laryngeal cancer
dc.subject.othersalvage laryngectomy
dc.subject.otherlaryngeal squamous cell carcinoma
dc.titlePositron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/136682/1/hed24719.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/136682/2/hed24719_am.pdf
dc.identifier.doi10.1002/hed.24719
dc.identifier.sourceHead & Neck
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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