Positron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer
dc.contributor.author | Rosko, Andrew | |
dc.contributor.author | Birkeland, Andrew | |
dc.contributor.author | Shuman, Andrew | |
dc.contributor.author | Prince, Mark | |
dc.contributor.author | Bradford, Carol | |
dc.contributor.author | Wolf, Gregory | |
dc.contributor.author | Worden, Francis | |
dc.contributor.author | Eisbruch, Avraham | |
dc.contributor.author | Srinivasan, Ashok | |
dc.contributor.author | Wong, Ka Kit | |
dc.contributor.author | Spector, Matthew E. | |
dc.date.accessioned | 2017-05-10T17:47:46Z | |
dc.date.available | 2018-07-09T17:42:24Z | en |
dc.date.issued | 2017-05 | |
dc.identifier.citation | Rosko, Andrew; Birkeland, Andrew; Shuman, Andrew; Prince, Mark; Bradford, Carol; Wolf, Gregory; Worden, Francis; Eisbruch, Avraham; Srinivasan, Ashok; Wong, Ka Kit; Spector, Matthew E. (2017). "Positron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer." Head & Neck 39(5): 980-987. | |
dc.identifier.issn | 1043-3074 | |
dc.identifier.issn | 1097-0347 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/136682 | |
dc.description.abstract | BackgroundThe purpose of this study was to evaluate the predictive value of positron emission tomography (PET)‐CT in identifying occult nodal metastasis in clinically and radiographically N0 patients with recurrent laryngeal cancer undergoing salvage laryngectomy.MethodsRetrospective review of 46 clinically and radiographically N0 patients with recurrent laryngeal cancer who underwent a PET‐CT examination before salvage laryngectomy with neck dissection from January 1, 2002, to December 31, 2014, was performed.ResultsTwo patients (16.7%) had true‐positive PET‐CT results, whereas 10 patients (83.3%) had false‐negative scans, 1 patient (2.9%) had a false‐positive result and 33 patients (97.1%) had a true‐negative PET‐CT. The sensitivity of PET‐CT was 16.7% (95% confidence interval [CI], 3.5% to 46.0%) with a specificity of 97.1% (95% CI, 83.8% to 99.9%), positive predictive value (PPV) of 66.7% (95% CI, 20.2% to 94.4%), and negative predictive value (NPV) of 76.7% (95% CI, 62.1% to 87.0%).ConclusionPET‐CT has poor sensitivity and NPV making PET‐CT an imperfect predictor of nodal disease in recurrent laryngeal cancer. © 2017 Wiley Periodicals, Inc. Head Neck 39: 980–987, 2017 | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | positron emission tomography (PET)‐CT | |
dc.subject.other | occult nodal metastasis | |
dc.subject.other | recurrent laryngeal cancer | |
dc.subject.other | salvage laryngectomy | |
dc.subject.other | laryngeal squamous cell carcinoma | |
dc.title | Positron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer | |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Otolaryngology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/136682/1/hed24719.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/136682/2/hed24719_am.pdf | |
dc.identifier.doi | 10.1002/hed.24719 | |
dc.identifier.source | Head & Neck | |
dc.identifier.citedreference | Stuckensen T, Kovács AF, Adams S, Baum RP. Staging of the neck in patients with oral cavity squamous cell carcinomas: a prospective comparison of PET, ultrasound, CT and MRI. J Craniomaxillofac Surg 2000; 28: 319 – 324. | |
dc.identifier.citedreference | Hannah A, Scott AM, Tochon–Danguy H, et al. Evaluation of 18 F‐fluorodeoxyglucose positron emission tomography and computed tomography with histopathologic correlation in the initial staging of head and neck cancer. Ann Surg 2002; 236: 208 – 217. | |
dc.identifier.citedreference | Kim SY, Kim JS, Yi JS, et al. Evaluation of 18F‐FDG PET/CT and CT/MRI with histopathologic correlation in patients undergoing salvage surgery for head and neck squamous cell carcinoma. Ann Surg Oncol 2011; 18: 2579 – 2584. | |
dc.identifier.citedreference | Kitagawa Y, Nishizawa S, Sano K, et al. Prospective comparison of 18F‐FDG PET with conventional imaging modalities (MRI, CT, and 67Ga scintigraphy) in assessment of combined intraarterial chemotherapy and radiotherapy for head and neck carcinoma. J Nucl Med 2003; 44: 198 – 206. | |
dc.identifier.citedreference | Kitagawa Y, Sadato N, Azuma H, et al. FDG PET to evaluate combined intra‐arterial chemotherapy and radiotherapy of head and neck neoplasms. J Nucl Med 1999; 40: 1132 – 1137. | |
dc.identifier.citedreference | Kitagawa Y, Sano K, Nishizawa S, et al. FDG‐PET for prediction of tumour aggressiveness and response to intra‐arterial chemotherapy and radiotherapy in head and neck cancer. Eur J Nucl Med Mol Imaging 2003; 30: 63 – 71. | |
dc.identifier.citedreference | Kresnik E, Mikosch P, Gallowitsch HJ, et al. Evaluation of head and neck cancer with 18F‐FDG PET: a comparison with conventional methods. Eur J Nucl Med 2001; 28: 816 – 821. | |
dc.identifier.citedreference | Lowe VJ, Dunphy FR, Varvares M, et al. Evaluation of chemotherapy response in patients with advanced head and neck cancer using [F‐18]fluorodeoxyglucose positron emission tomography. Head Neck 1997; 19: 666 – 674. | |
dc.identifier.citedreference | Spector ME, Chinn SB, Rosko AJ, et al. Diagnostic modalities for distant metastasis in head and neck squamous cell carcinoma: are we changing life expectancy? Laryngoscope 2012; 122: 1507 – 1511. | |
dc.identifier.citedreference | Terhaard CH, Bongers V, van Rijk PP, Hordijk GJ. F‐18‐fluoro‐deoxy‐glucose positron‐emission tomography scanning in detection of local recurrence after radiotherapy for laryngeal/pharyngeal cancer. Head Neck 2001; 23: 933 – 941. | |
dc.identifier.citedreference | Wong RJ, Lin DT, Schöder H, et al. Diagnostic and prognostic value of [(18)F]fluorodeoxyglucose positron emission tomography for recurrent head and neck squamous cell carcinoma. J Clin Oncol 2002; 20: 4199 – 4208. | |
dc.identifier.citedreference | Brouwer J, de Bree R, Comans EF, et al. Improved detection of recurrent laryngeal tumor after radiotherapy using (18)FDG‐PET as initial method. Radiother Oncol 2008; 87: 217 – 220. | |
dc.identifier.citedreference | Gilbert MR, Branstetter BF 4th, Kim S. Utility of positron‐emission tomography/computed tomography imaging in the management of the neck in recurrent laryngeal cancer. Laryngoscope 2012; 122: 821 – 825. | |
dc.identifier.citedreference | Hyde NC, Prvulovich E, Newman L, Waddington WA, Visvikis D, Ell P. A new approach to pre‐treatment assessment of the N0 neck in oral squamous cell carcinoma: the role of sentinel node biopsy and positron emission tomography. Oral Oncol 2003; 39: 350 – 360. | |
dc.identifier.citedreference | Nahmias C, Carlson ER, Duncan LD, et al. Positron emission tomography/computerized tomography (PET/CT) scanning for preoperative staging of patients with oral/head and neck cancer. J Oral Maxillofac Surg 2007; 65: 2524 – 2535. | |
dc.identifier.citedreference | Paulus P, Sambon A, Vivegnis D, et al. 18FDG‐PET for the assessment of primary head and neck tumors: clinical, computed tomography, and histopathological correlation in 38 patients. Laryngoscope 1998; 108: 1578 – 1583. | |
dc.identifier.citedreference | Wensing BM, Vogel WV, Marres HA, et al. FDG‐PET in the clinically negative neck in oral squamous cell carcinoma. Laryngoscope 2006; 116: 809 – 813. | |
dc.identifier.citedreference | Yamazaki Y, Saitoh M, Notani K, et al. Assessment of cervical lymph node metastases using FDG‐PET in patients with head and neck cancer. Ann Nucl Med 2008; 22: 177 – 184. | |
dc.identifier.citedreference | Agresti A, Coull BA. Approximate is better than “exact” for interval estimation of binomial proportions. Am Stat 1998; 52: 119 – 126. | |
dc.identifier.citedreference | Warburg O. On the origin of cancer cells. Science 1956; 123: 309 – 314. | |
dc.identifier.citedreference | Ong SC, Schöder H, Lee NY, et al. Clinical utility of 18F‐FDG PET/CT in assessing the neck after concurrent chemoradiotherapy for locoregional advanced head and neck cancer. J Nucl Med 2008; 49: 532 – 540. | |
dc.identifier.citedreference | Schöder H, Carlson DL, Kraus DH, et al. 18F‐FDG PET/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT/MRI. J Nucl Med 2006; 47: 755 – 762. | |
dc.identifier.citedreference | Kyzas PA, Evangelou E, Denaxa–Kyza D, Ioannidis JP. 18F‐fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta‐analysis. J Natl Cancer Inst 2008; 100: 712 – 720. | |
dc.identifier.citedreference | Purohit BS, Ailianou A, Dulguerov N, Becker CD, Ratib O, Becker M. FDG‐PET/CT pitfalls in oncological head and neck imaging. Insights Imaging 2014; 5: 585 – 602. | |
dc.identifier.citedreference | Vecchio TJ. Predictive value of a single diagnostic test in unselected populations. N Engl J Med 1966; 274: 1171 – 1173. | |
dc.identifier.citedreference | Weiss MH, Harrison LB, Isaacs RS. Use of decision analysis in planning a management strategy for the stage N0 neck. Arch Otolaryngol Head Neck Surg 1994; 120: 699 – 702. | |
dc.identifier.citedreference | Ferlito A, Rinaldo A, Silver CE, et al. Neck dissection for laryngeal cancer. J Am Coll Surg 2008; 207: 587 – 593. | |
dc.identifier.citedreference | Rutledge JW, Spencer H, Moreno MA. Predictors for perioperative outcomes following total laryngectomy: a University HealthSystem Consortium Discharge Database Study. Otolaryngol Head Neck Surg 2014; 151: 81 – 86. | |
dc.identifier.citedreference | Weber RS, Berkey BA, Forastiere A, et al. Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation Therapy Oncology Group trial 91‐11. Arch Otolaryngol Head Neck Surg 2003; 129: 44 – 49. | |
dc.identifier.citedreference | Graboyes EM, Yang Z, Kallogjeri D, Diaz JA, Nussenbaum B. Patients undergoing total laryngectomy: an at‐risk population for 30‐day unplanned readmission. JAMA Otolaryngol Head Neck Surg 2014; 140: 1157 – 1165. | |
dc.identifier.citedreference | Urba S, Wolf G, Eisbruch A, et al. Single‐cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm. J Clin Oncol 2006; 24: 593 – 598. | |
dc.identifier.citedreference | Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 1996; 88: 890 – 899. | |
dc.identifier.citedreference | Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003; 349: 2091 – 2098. | |
dc.identifier.citedreference | Chone CT, Yonehara E, Martins JE, Altemani A, Crespo AN. Importance of anterior commissure in recurrence of early glottic cancer after laser endoscopic resection. Arch Otolaryngol Head Neck Surg 2007; 133: 882 – 887. | |
dc.identifier.citedreference | Hakeem AH, Tubachi J, Pradhan SA. Significance of anterior commissure involvement in early glottic squamous cell carcinoma treated with trans‐oral CO2 laser microsurgery. Laryngoscope 2013; 123: 1912 – 1917. | |
dc.identifier.citedreference | Clark JR, de Almeida J, Gilbert R, et al. Primary and salvage (hypo)pharyngectomy: analysis and outcome. Head Neck 2006; 28: 671 – 677. | |
dc.identifier.citedreference | Paydarfar JA, Birkmeyer NJ. Complications in head and neck surgery: a meta‐analysis of postlaryngectomy pharyngocutaneous fistula. Arch Otolaryngol Head Neck Surg 2006; 132: 67 – 72. | |
dc.identifier.citedreference | Li M, Lorenz RR, Khan MJ, et al. Salvage laryngectomy in patients with recurrent laryngeal cancer in the setting of nonoperative treatment failure. Otolaryngol Head Neck Surg 2013; 149: 245 – 251. | |
dc.identifier.citedreference | Bohannon IA, Desmond RA, Clemons L, Magnuson JS, Carroll WR, Rosenthal EL. Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Laryngoscope 2010; 120: 58 – 61. | |
dc.identifier.citedreference | Farrag TY, Lin FR, Cummings CW, et al. Neck management in patients undergoing postradiotherapy salvage laryngeal surgery for recurrent/persistent laryngeal cancer. Laryngoscope 2006; 116: 1864 – 1866. | |
dc.identifier.citedreference | Wax MK, Touma BJ. Management of the N0 neck during salvage laryngectomy. Laryngoscope 1999; 109: 4 – 7. | |
dc.identifier.citedreference | Yao M, Roebuck JC, Holsinger FC, Myers JN. Elective neck dissection during salvage laryngectomy. Am J Otolaryngol 2005; 26: 388 – 392. | |
dc.identifier.citedreference | Birkeland AC, Rosko AJ, Issa MR, et al. Occult nodal disease prevalence and distribution in recurrent laryngeal cancer requiring salvage laryngectomy. Otolaryngol Head Neck Surg 2016; 154: 473 – 479. | |
dc.identifier.citedreference | Ng SH, Yen TC, Liao CT, et al. 18F‐FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med 2005; 46: 1136 – 1143. | |
dc.identifier.citedreference | Adams S, Baum RP, Stuckensen T, Bitter K, Hör G. Prospective comparison of 18F‐FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer. Eur J Nucl Med 1998; 25: 1255 – 1260. | |
dc.identifier.citedreference | Braams JW, Pruim J, Freling NJ, et al. Detection of lymph node metastases of squamous‐cell cancer of the head and neck with FDG‐PET and MRI. J Nucl Med 1995; 36: 211 – 216. | |
dc.identifier.citedreference | Abgral R, Querellou S, Potard G, et al. Does 18F‐FDG PET/CT improve the detection of posttreatment recurrence of head and neck squamous cell carcinoma in patients negative for disease on clinical follow‐up? J Nucl Med 2009; 50: 24 – 29. | |
dc.identifier.citedreference | Conessa C, Hervé S, Foehrenbach H, Poncet JL. FDG‐PET scan in local follow‐up of irradiated head and neck squamous cell carcinomas. Ann Otol Rhinol Laryngol 2004; 113: 628 – 635. | |
dc.identifier.citedreference | Döbert N, Kovács AF, Menzel C, et al. The prognostic value of FDG PET in head and neck cancer. Correlation with histopathology. Q J Nucl Med Mol Imaging 2005; 49: 253 – 257. | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.