An updated radiosynthesis of [18F]AV1451 for tau PET imaging
dc.contributor.author | Mossine, Andrew V | |
dc.contributor.author | Brooks, Allen F | |
dc.contributor.author | Henderson, Bradford D | |
dc.contributor.author | Hockley, Brian G | |
dc.contributor.author | Frey, Kirk A | |
dc.contributor.author | Scott, Peter J H | |
dc.date.accessioned | 2017-06-11T03:15:15Z | |
dc.date.available | 2017-06-11T03:15:15Z | |
dc.date.issued | 2017-06-06 | |
dc.identifier.citation | EJNMMI Radiopharmacy and Chemistry. 2017 Jun 06;2(1):7 | |
dc.identifier.uri | http://dx.doi.org/10.1186/s41181-017-0027-7 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/136917 | |
dc.description.abstract | Abstract Background [18F]AV1451 is a commonly used radiotracer for imaging tau deposits in Alzheimer’s disease (AD) and related non-AD tauopathies. Existing radiosyntheses of [18F]AV1451 require complex purifications to provide doses suitable for use in clinical imaging studies. To address this issue, we have modified the synthesis of [18F]AV1451 to use only 0.5 mg precursor, optimized the Boc-deprotection step and developed a simplified method for HPLC purification of the radiotracer. Results An optimized [18F]AV1451 synthesis using a TRACERLab FXFN module led to high radiochemical yield (202 ± 57 mCi per synthesis) and doses with excellent radiochemical purity (98 ± 1%) and good specific activity (2521 ± 623 Ci/mmol). Conclusion An updated and operationally simple synthesis of [18F]AV1451 has been developed that is fully automated and prepares radiotracer doses suitable for use in clinical tau PET studies. | |
dc.title | An updated radiosynthesis of [18F]AV1451 for tau PET imaging | |
dc.type | Article | en_US |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/136917/1/41181_2017_Article_27.pdf | |
dc.language.rfc3066 | en | |
dc.rights.holder | The Author(s) | |
dc.date.updated | 2017-06-11T03:15:17Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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