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Impact of xerostomia on dysphagia after chemotherapy–intensity‐modulated radiotherapy for oropharyngeal cancer: Prospective longitudinal study
dc.contributor.authorVainshtein, Jeffrey M.
dc.contributor.authorSamuels, Stuart
dc.contributor.authorTao, Yebin
dc.contributor.authorLyden, Teresa
dc.contributor.authorHaxer, Marc
dc.contributor.authorSpector, Matthew
dc.contributor.authorSchipper, Matthew
dc.contributor.authorEisbruch, Avraham
dc.date.accessioned2017-06-16T20:06:59Z
dc.date.available2017-06-16T20:06:59Z
dc.date.issued2016-04
dc.identifier.citationVainshtein, Jeffrey M.; Samuels, Stuart; Tao, Yebin; Lyden, Teresa; Haxer, Marc; Spector, Matthew; Schipper, Matthew; Eisbruch, Avraham (2016). "Impact of xerostomia on dysphagia after chemotherapy–intensity‐modulated radiotherapy for oropharyngeal cancer: Prospective longitudinal study." Head & Neck 38(S1): E1605-E1612.
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.urihttps://hdl.handle.net/2027.42/137188
dc.description.abstractBackgroundThe purpose of this study was to assess how xerostomia affects dysphagia.MethodsProspective longitudinal studies of 93 patients with oropharyngeal cancer treated with definitive chemotherapy–intensity‐modulated radiotherapy (IMRT). Observer‐rated dysphagia (ORD), patient‐reported dysphagia (PRD), and patient‐reported xerostomia (PRX) assessment of the swallowing mechanics by videofluoroscopy (videofluoroscopy score), and salivary flow rates, were prospectively assessed from pretherapy through 2 years.ResultsORD grades ≥2 were rare and therefore not modeled. Of patients with no/mild videofluoroscopy abnormalities, a substantial proportion had PRD that peaked 3 months posttherapy and subsequently improved. Through 2 years, highly significant correlations were observed between PRX and PRD scores for all patients, including those with no/mild videofluoroscopy abnormalities. Both PRX and videofluoroscopy scores were highly significantly associated with PRD. On multivariate analysis, PRX score was a stronger predictor of PRD than the videofluoroscopy score.ConclusionXerostomia contributes significantly to PRD. Efforts to further decrease xerostomia, in addition to sparing parotid glands, may translate into improvements in PRD. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1605–E1612, 2016
dc.publisherWiley Periodicals, Inc.
dc.subject.otherxerostomia
dc.subject.otherhead neck cancer
dc.subject.otherpatient‐reported outcomes
dc.subject.otherintensity‐modulated radiotherapy (IMRT)
dc.subject.otherdysphagia
dc.titleImpact of xerostomia on dysphagia after chemotherapy–intensity‐modulated radiotherapy for oropharyngeal cancer: Prospective longitudinal study
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137188/1/hed24286_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137188/2/hed24286.pdf
dc.identifier.doi10.1002/hed.24286
dc.identifier.sourceHead & Neck
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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