Meta‐analysis of randomized controlled trials comparing 17α‐hydroxyprogesterone caproate and vaginal progesterone for the prevention of recurrent spontaneous preterm delivery
dc.contributor.author | Oler, Elizabeth | |
dc.contributor.author | Eke, Ahizechukwu C. | |
dc.contributor.author | Hesson, Ashley | |
dc.date.accessioned | 2017-06-16T20:09:36Z | |
dc.date.available | 2018-08-28T15:28:59Z | en |
dc.date.issued | 2017-07 | |
dc.identifier.citation | Oler, Elizabeth; Eke, Ahizechukwu C.; Hesson, Ashley (2017). "Meta‐analysis of randomized controlled trials comparing 17α‐hydroxyprogesterone caproate and vaginal progesterone for the prevention of recurrent spontaneous preterm delivery." International Journal of Gynecology & Obstetrics 138(1): 12-16. | |
dc.identifier.issn | 0020-7292 | |
dc.identifier.issn | 1879-3479 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/137297 | |
dc.description.abstract | BackgroundVaginal progesterone and 17α‐hydroxyprogesterone (17α‐OHP) are both used to prevent preterm delivery in women who have experienced spontaneous preterm delivery (SPTD) previously. Randomized trial data of the comparative effectiveness of these interventions have been mixed.ObjectivesTo compare the efficacy of intramuscular 17α‐OHP and vaginal progesterone in the prevention of recurrent SPTD.Search strategyCochrane Central Register of Controlled Trials, African Journals Online, Embase, Google Scholar, ISI Web of Science, LILACS, CINAHL, PubMed, and registers of ongoing trials were searched using keywords related to 17α‐OHP, vaginal progesterone, and preterm delivery.Selection criteriaRandomized controlled trials published between January 1, 1966, and November 30, 2016, comparing 17α‐OHP and vaginal progesterone for the prevention of recurrent SPTD during singleton pregnancies were included.Data collection and analysisStudy data were extracted and meta‐analyses were performed when outcomes were comparable.Main resultsThe meta‐analyses included data from three randomized trials. Lower rates of SPTD before 34 weeks (relative risk 0.71, 95% confidence interval 0.53–0.95) and before 32 weeks (relative risk 0.62, 95% confidence interval 0.40–0.94) of pregnancy were observed among patients treated with vaginal progesterone.ConclusionsVaginal progesterone and 17α‐OHP were comparable for the prevention of recurrent SPTD in singleton pregnancies; vaginal progesterone could be superior.Vaginal progesterone was comparable to 17α‐hydroxyprogesterone for the prevention of recurrent spontaneous preterm delivery in patients with singleton pregnancies. | |
dc.publisher | The Cochrane Collaboration | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | Vaginal progesterone | |
dc.subject.other | Recurrent preterm delivery | |
dc.subject.other | Preterm labor | |
dc.subject.other | 17 alpha progesterone | |
dc.title | Meta‐analysis of randomized controlled trials comparing 17α‐hydroxyprogesterone caproate and vaginal progesterone for the prevention of recurrent spontaneous preterm delivery | |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/137297/1/ijgo12166.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/137297/2/ijgo12166_am.pdf | |
dc.identifier.doi | 10.1002/ijgo.12166 | |
dc.identifier.source | International Journal of Gynecology & Obstetrics | |
dc.identifier.citedreference | Martin JA, Hamilton BE, Osterman MJK, Curtin SC, Mathews TJ. Centers for Disease Control and Prevention National Center for Health Statistics National Vital Statistics System births: Final data for 2013. Natl Vital Stat Rep. 2015; 64: 1 – 68. | |
dc.identifier.citedreference | Meis PJ, Klebanoff M, Thom E, et al. Prevention of recurrent preterm delivery by 17 alpha‐hydroxyprogesterone caproate. N Engl J Med. 2003; 348: 2379 – 2385. | |
dc.identifier.citedreference | Callaghan WM, MacDorman MF, Rasmussen SA, Qin C, Lackritz EM. The contribution of preterm birth to infant mortality rates in the United States. Pediatrics. 2006; 118: 1566 – 1573. | |
dc.identifier.citedreference | Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008; 371: 75 – 84. | |
dc.identifier.citedreference | Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta‐analyses. BMJ. 2003; 327: 557 – 560. | |
dc.identifier.citedreference | Deeks JJ, Higgins JPT, Altman DG. Chapter 9: Analyzing data and undertaking meta‐analyses. In: Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). Chichester: The Cochrane Collaboration; 2011. | |
dc.identifier.citedreference | Higgins JPT, Altman DG, Sterne JAC. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). Chichester: The Cochrane Collaboration; 2011. | |
dc.identifier.citedreference | Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta‐analyses of studies that evaluate health care interventions: Explanation and elaboration. Ann Intern Med. 2009; 151: W65 – W94. | |
dc.identifier.citedreference | Maher MA, Abdelaziz A, Ellaithy M, Bazeed MF. Prevention of preterm birth: A randomized trial of vaginal compared with intramuscular progesterone. Acta Obstet Gynecol Scand. 2013; 92: 215 – 222. | |
dc.identifier.citedreference | Elimian A, Smith K, Williams M, Knudtson E, Goodman JR, Escobedo MB. A randomized controlled trial of intramuscular versus vaginal progesterone for the prevention of recurrent preterm birth. Int J Gynecol Obstet. 2016; 134: 169 – 172. | |
dc.identifier.citedreference | Bafghi AS, Bahrami E, Sekhavat L. Comparative Study of Vaginal versus Intramuscular Progesterone in the Prevention of Preterm Delivery: A Randomized Clinical Trial. Electron Physician. 2015; 7: 1301 – 1309. | |
dc.identifier.citedreference | Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007; 357: 462 – 469. | |
dc.identifier.citedreference | American College of Obstetricians and Gynecologists. Use of progesterone to reduce preterm birth: ACOG committee opinion no. 419. Obstet Gynecol. 2008; 112: 963 – 965. | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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