View Item 

Show simple item record

Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders:
dc.contributor.authorPerry, LeeAnn M.
dc.contributor.authorGoldstein‐piekarski, Andrea N.
dc.contributor.authorWilliams, Leanne M.
dc.date.accessioned2017-06-16T20:09:52Z
dc.date.available2018-03-01T16:43:51Zen
dc.date.issued2017-01-02
dc.identifier.citationPerry, LeeAnn M.; Goldstein‐piekarski, Andrea N. ; Williams, Leanne M. (2017). "Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders:." Journal of Neuroscience Research 95(1-2): 737-762.
dc.identifier.issn0360-4012
dc.identifier.issn1097-4547
dc.identifier.urihttps://hdl.handle.net/2027.42/137310
dc.publisherWiley Periodicals, Inc.
dc.subject.othersuicide
dc.subject.otherconduct disorder
dc.subject.otherpersonality
dc.subject.otherearlyâ life stress
dc.subject.otheranxiety
dc.subject.otheramygdala
dc.titleSex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders:
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biology
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137310/1/jnr23877.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137310/2/jnr23877_am.pdf
dc.identifier.doi10.1002/jnr.23877
dc.identifier.sourceJournal of Neuroscience Research
dc.identifier.citedreferenceRisch N, Herrell R, Lehner T, Liang K, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR. 2009. Interaction between the serotonin transporter gene (5â HTTLPR), stressful life events, and risk of depression: a metaâ analysis. JAMA 301: 2462 â 2471.
dc.identifier.citedreferenceWay BM, Taylor SE. 2010. The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress. Biol Psychiatry 67: 487 â 492.
dc.identifier.citedreferenceWeder N, Yang BZ, Douglasâ Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. 2009. MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma. Biol Psychiatry 65: 417 â 424.
dc.identifier.citedreferenceWendland JR, Martin BJ, Kruse MR, Lesch K, Murphy DL. 2006. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5â HTTLPR and rs25531. Mol Psychiatry 11: 224 â 226.
dc.identifier.citedreferenceWidom CS, Brzustowicz LM. 2006. MAOA and the â cycle of violenceâ : childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biol Psychiatry 60: 684 â 689.
dc.identifier.citedreferenceWijchers PJ, Yandim C, Panousopoulou E, Ahmad M, Harker N, Saveliev A, Burgoyne PS, Festenstein R. 2010. Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well. Dev Cell 19: 477 â 484.
dc.identifier.citedreferenceWilliams LM. 2016. Precision psychiatry: a neural circuit taxonomy for depression and anxiety. Lancet Psychiatry 3: 472 â 480.
dc.identifier.citedreferenceWilliams LM, Barton MJ, Kemp AH, Liddell BJ, Peduto A, Gordon E, Bryant RA. 2005. Distinct amygdalaâ autonomic arousal profiles in response to fear signals in healthy males and females. Neuroimage 28: 618 â 626.
dc.identifier.citedreferenceWilliams LM, Gatt JM, Kuan SA, Dobsonâ Stone C, Palmer DM, Paul RH, Song L, Costa PT, Schofield PR, Gordon E. 2009. A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index. Neuropsychopharmacology 34: 1797 â 1809.
dc.identifier.citedreferenceWilliams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Staffordâ Smith M, Suarez EC, Clary GL, Svenson IK, Siegler IC. 2003. Serotoninâ related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology 28: 533 â 541.
dc.identifier.citedreferenceWu JB, Chen K, Li Y, Lau YC, Shih JC. 2009. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J 23: 4029 â 4038.
dc.identifier.citedreferenceWüst S, Kumsta R, Treutlein J, Frank J, Entringer S, Schulze TG, Rietschel M. 2009. Sexâ specific association between the 5â HTT geneâ linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology 34: 972 â 982.
dc.identifier.citedreferenceYang J, Lee M, Lee S, Lee B, Kim S, Joe S, Jung I, Choi I, Ham B. 2010. Association between tryptophan hydroxylase 2 polymorphism and angerâ related personality traits among young Korean women. Neuropsychobiology 62: 158 â 163.
dc.identifier.citedreferenceYoon H, Kim Y. 2009. TPH2â 703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 33: 403 â 409.
dc.identifier.citedreferenceYoon H, Lee H, Kim L, Lee M, Ham B. 2012. Impact of tryptophan hydroxylase 2â Gâ 703T polymorphism on angerâ related personality traits and orbitofrontal cortex. Behav Brain Res 231: 105 â 110.
dc.identifier.citedreferenceYu YW, Tsai S, Hong C, Chen T, Chen M, Yang C. 2005a. Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology 30: 1719 â 1723.
dc.identifier.citedreferenceYu YW, Yang C, Wu H, Tsai S, Hong C, Chen M, Chen T. 2005b. Association study of a functional MAOAâ uVNTR gene polymorphism and personality traits in Chinese young females. Neuropsychobiology 52: 118 â 121.
dc.identifier.citedreferenceZaboli G, Gizatullin R, Nilsonne A, Wilczek A, Jönsson EG, Ahnemark E, Asberg M, Leopardi R. 2006. Tryptophan hydroxylaseâ 1 gene variants associate with a group of suicidal borderline women. Neuropsychopharmacology 31: 1982 â 1990.
dc.identifier.citedreferenceZhang L, Liu L, Li X, Song Y, Liu J. 2015. Serotonin transporter gene polymorphism (5â HTTLPR) influences trait anxiety by modulating the functional connectivity between the amygdala and insula in Han Chinese males. Hum Brain Mapp 36: 2732 â 2742.
dc.identifier.citedreferenceZhang X, Beaulieu J, Sotnikova TD, Gainetdinov RR, Caron MG. 2004. Tryptophan hydroxylaseâ 2 controls brain serotonin synthesis. Science 305: 217 â 217.
dc.identifier.citedreferenceZhang X, Gainetdinov RR, Beaulieu J, Sotnikova TD, Burch LH, Williams RB, Schwartz DA, Krishnan KR, Caron MG. 2005. Lossâ ofâ function mutation in tryptophan hydroxylaseâ 2 identified in unipolar major depression. Neuron 45: 11 â 16.
dc.identifier.citedreferenceZhang Y, Zhang C, Yuan G, Yao J, Cheng Z, Liu C, Liu Q, Wan G, Shi G, Cheng Y, Ling Y, Li K. 2010. Effect of tryptophan hydroxylaseâ 2 rs7305115 SNP on suicide attempts risk in major depression. Behav Brain Funct 6: 49.
dc.identifier.citedreferenceZhou Z, Roy A, Lipsky R, Kuchipudi K, Zhu G, Taubman J, Enoch M, Virkkunen M, Goldman D. 2005. Haplotypeâ based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5â hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry 62: 1109 â 1118.
dc.identifier.citedreferenceZill P, Büttner A, Eisenmenger W, Möller H, Bondy B, Ackenheil M. 2004a. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry 56: 581 â 586.
dc.identifier.citedreferenceZill P, Baghai TC, Zwanzger P, Schüle C, Eser D, Rupprecht R, Möller H, Bondy B, Ackenheil M. 2004b. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry 9: 1030 â 1036.
dc.identifier.citedreferenceZill P, Büttner A, Eisenmenger W, Möller H, Ackenheil M, Bondy B. 2007. Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a postmortem study. J Psychiatr Res 41: 168 â 173.
dc.identifier.citedreferenceZoccolillo M. 1992. Coâ occurrence of conduct disorder and its adult outcomes with depressive and anxiety disorders: a review. J Am Acad Child Adolesc Psychiatry 31: 547 â 556.
dc.identifier.citedreferenceAdkins DE, Daw JK, McClay JL, van den Oord EJ. 2012. The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood. Dev Psychopathol 24: 267 â 285.
dc.identifier.citedreferenceAlexander N, Klucken T, Koppe G, Osinsky R, Walter B, Vaitl D, Sammer G, Stark R, Hennig J. 2012. Interaction of the serotonin transporterâ linked polymorphic region and environmental adversity: increased amygdalaâ hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity. Biol Psychiatry 72: 49 â 56.
dc.identifier.citedreferenceAliaâ Klein N, Goldstein RZ, Tomasi D, Woicik PA, Moeller SJ, Williams B, Craig IW, Telang F, Biegon A, Wang G, Fowler JS, Volkow ND. 2009. Neural mechanisms of anger regulation as a function of genetic risk for violence. Emotion 9: 385 â 396.
dc.identifier.citedreferenceAltemus M. 2006. Sex differences in depression and anxiety disorders: potential biological determinants. Horm Behav 50: 534 â 538.
dc.identifier.citedreferenceAncelin M, Carrière I, Boulenger J, Malafosse A, Stewart R, Cristol J, Ritchie K, Chaudieu I, Dupuy A. 2010. Gender and genotype modulation of the association between lipid levels and depressive symptomatology in communityâ dwelling elderly (the ESPRIT study). Biol Psychiatry 68: 125 â 132.
dc.identifier.citedreferenceAndre K, Kampman O, Viikki M, Illi A, Setäläâ Soikkeli E, Poutanen O, Mononen N, Leinonen E, Lehtimäki T. 2013. TPH1 A218C polymorphism and temperament in major depression. BMC Psychiatry 13: 118.
dc.identifier.citedreferenceAnttila S, Viikki M, Huuhka K, Huuhka M, Huhtala H, Rontu R, Lehtimäki T, Leinonen E. 2009. TPH2 polymorphisms may modify clinical picture in treatmentâ resistant depression. Neurosci Lett 464: 43 â 46.
dc.identifier.citedreferenceAntypa N, Cerit H, Kruijt AW, Verhoeven FEA, Van der Does AJ. 2011. Relationships among 5â HTT genotype, life events, and gender in the recognition of facial emotions. Neuroscience 172: 303 â 313.
dc.identifier.citedreferenceArmbruster D, Mueller A, Strobel A, Kirschbaum C, Lesch K, Brocke B. 2010. Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults. Biol Psychol 83: 214 â 221.
dc.identifier.citedreferenceAslund C, Leppert J, Comasco E, Nordquist N, Oreland L, Nilsson KW. 2009. Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A populationâ based study. Behav Genet 39: 524 â 531.
dc.identifier.citedreferenceAslund C, Nordquist N, Comasco E, Leppert J, Oreland L, Nilsson KW. 2011. Maltreatment, MAOA, and delinquency: sex differences in geneâ environment interaction in a large populationâ based cohort of adolescents. Behav Genet 41: 262 â 272.
dc.identifier.citedreferenceAslund C, Comasco E, Nordquist N, Leppert J, Oreland L, Nilsson KW. 2013. Selfâ reported family socioeconomic status, the 5â HTTLPR genotype, and delinquent behavior in a communityâ based adolescent population. Aggress Behav 39: 52 â 63.
dc.identifier.citedreferenceAvery BM, Vrshekâ Schallhorn S. 2016. Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress I: effects in males and females. Psychoneuroendocrinology 70: 134 â 141.
dc.identifier.citedreferenceBacaâ García E, Vaquero C, Diazâ Sastre C, Saizâ Ruiz J, Fernándezâ Piqueras J, de Leon J. 2002. A genderâ specific association between the serotonin transporter gene and suicide attempts. Neuropsychopharmacology 26: 692 â 695.
dc.identifier.citedreferenceBachâ Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ, Sibille E, Tamir H, Mann JJ, Arango V. 2005. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology 31: 814 â 824.
dc.identifier.citedreferenceBale TL, Epperson CN. 2015. Sex differences and stress across the lifespan. Nat Neurosci 18: 1413 â 1420.
dc.identifier.citedreferenceBarr CS, Newman TK, Schwandt M, Shannon C, Dvoskin RL, Lindell SG, Taubman J, Thompson B, Champoux M, Lesch KP, Goldman D, Suomi SJ, Higley JD. 2004. Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A 101: 12358 â 12363.
dc.identifier.citedreferenceBaune BT, Hohoff C, Mortensen LS, Deckert J, Arolt V, Domschke K. 2008. Serotonin transporter polymorphism (5â HTTLPR) association with melancholic depression: a female specific effect? Depress Anxiety 25: 920 â 925.
dc.identifier.citedreferenceBeaver KM, Vaughn MG, Wright JP, Delisi M. 2012. An interaction between perceived stress and 5HTTLPR genotype in the prediction of stable depressive symptomatology. Am J Orthopsychiatry 82: 260 â 266.
dc.identifier.citedreferenceBeaver KM, Barnes JC, Boutwell BB. 2013. The 2â repeat allele of the MAOA gene confers an increased risk for shooting and stabbing behaviors. Psychiatr Q 85: 257 â 265.
dc.identifier.citedreferenceBeevers CG, Pacheco J, Clasen P, McGeary JE, Schnyer D. 2010a. Prefrontal morphology, 5â HTTLPR polymorphism, and biased attention for emotional stimuli. Genes Brain Behav 9: 224 â 233.
dc.identifier.citedreferenceBeevers CG, Ellis AJ, Wells TT, McGeary JE. 2010b. Serotonin transporter gene promoter region polymorphism and selective processing of emotional images. Biol Psychol 83: 260 â 265.
dc.identifier.citedreferenceBeitchman JH, Mik HM, Ehtesham S, Douglas L, Kennedy JL. 2004. MAOA and persistent, pervasive childhood aggression. Mol Psychiatry 9: 546 â 547.
dc.identifier.citedreferenceBeitchman JH, Baldassarra L, Mik H, De Luca V, King N, Bender D, Ehtesham S, Kennedy JL. 2006. Serotonin transporter polymorphisms and persistent, pervasive childhood aggression. Am J Psychiatry 163: 1103 â 1105.
dc.identifier.citedreferenceBellivier F, Szöke A, Henry C, Lacoste J, Bottos C, Nostenâ Bertrand M, Hardy P, Rouillon F, Launay J, Laplanche J, Leboyer M. 2000. Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders. Biol Psychiatry 48: 319 â 322.
dc.identifier.citedreferenceBellivier F, Chaste P, Malafosse A. 2004. Association between the TPH gene A218C polymorphism and suicidal behavior: a metaâ analysis. Am J Med Genet B Neuropsychiatr Genet 124B: 87 â 91.
dc.identifier.citedreferenceBertolino A, Arciero G, Rubino V, Latorre V, De Candia M, Mazzola V, Blasi G, Caforio G, Hariri A, Kolachana B, Nardini M, Weinberger DR, Scarabino T. 2005. Variation of human amygdala response during threatening stimuli as a function of 5â ²HTTLPR genotype and personality style. Biol Psychiatry 57: 1517 â 1525.
dc.identifier.citedreferenceBlairâ West G, Cantor CH, Mellsop GW, Eyesonâ Annan M. 1999. Lifetime suicide risk in major depression: sex and age determinants. J Affect Disord 55: 171 â 178.
dc.identifier.citedreferenceBondy B, Erfurth A, de Jonge S, Krüger M, Meyer H. 2000. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5â HTTLPR) with violent suicide. Mol Psychiatry 5: 193 â 195.
dc.identifier.citedreferenceBooij L, Van der Does W, Benkelfat C, Bremner JD, Cowen PJ, Fava M, Gillin C, Leyton M, Moore P, Smith KA, Van der Kloot WA. 2002. Predictors of mood response to acute tryptophan depletion. A reanalysis. Neuropsychopharmacology 27: 852 â 861.
dc.identifier.citedreferenceBouma EMC, Riese H, Doornbos B, Ormel J, Oldehinkel AJ. 2012. Genetically based reduced MAOA and COMT functioning is associated with the cortisol stress response: a replication study. Mol Psychiatry 17: 119 â 121.
dc.identifier.citedreferenceBrocke B, Armbruster D, Muller J, Hensch T, Jacob CP, Lesch K, Kirschbaum C, Strobel A. 2006. Serotonin transporter gene variation impacts innate fear processing: acoustic startle response and emotional startle. Mol Psychiatry 11: 1106 â 1112.
dc.identifier.citedreferenceBrown GW, Ban M, Craig TKJ, Harris TO, Herbert J, Uher R. 2013. Serotonin transporter length polymorphism, childhood maltreatment, and chronic depression: a specific geneâ environment interaction. Depress Anxiety 30: 5 â 13.
dc.identifier.citedreferenceBrown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR. 2005. A regulatory variant of the human tryptophan hydroxylaseâ 2 gene biases amygdala reactivity. Mol Psychiatry 10: 884 â 888, 805.
dc.identifier.citedreferenceBrummett BH, Siegler IC, McQuoid DR, Svenson IK, Marchuk DA, Steffens DC. 2003. Associations among the NEO Personality Inventory, Revised and the serotonin transporter geneâ linked polymorphic region in elders: effects of depression and gender. Psychiatr Genet 13: 13 â 18.
dc.identifier.citedreferenceBrummett BH, Boyle SH, Siegler IC, Kuhn CM, Ashleyâ Koch A, Jonassaint CR, Züchner S, Collins A, Williams RB. 2008a. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5â HTTLPR). Behav Genet 38: 34 â 43.
dc.identifier.citedreferenceBrummett BH, Muller CL, Collins AL, Boyle SH, Kuhn CM, Siegler IC, Williams RB, Ashleyâ Koch A. 2008b. 5â HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet 38: 476 â 483.
dc.identifier.citedreferenceBrummett BH, Boyle SH, Siegler IC, Kuhn CM, Surwit RS, Garrett ME, Collins A, Ashleyâ Koch A, Williams RB. 2008c. HPA axis function in male caregivers: effect of the monoamine oxidaseâ A gene promoter (MAOAâ uVNTR). Biol Psychol 79: 250 â 255.
dc.identifier.citedreferenceBuckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Egan MF, Mattay VS, Weinberger DR, Meyerâ Lindenberg A. 2008. Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Mol Psychiatry 13: 313 â 324.
dc.identifier.citedreferenceByrd AL, Manuck SB. 2014. MAOA, childhood maltreatment, and antisocial behavior: metaâ analysis of a geneâ environment interaction. Biol Psychiatry 75: 9 â 17.
dc.identifier.citedreferenceCadoret RJ, Langbehn D, Caspers K, Troughton EP, Yucuis R, Sandhu HK, Philibert R. 2003. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Compr Psychiatry 44: 88 â 101.
dc.identifier.citedreferenceCampos SB, Miranda D, Souza BR, Pereira PA, Neves FS, Tramontina J, Kapczinski F, Romanoâ Silva M, Correa H. 2011. Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity. Psychiatr Genet 21: 106 â 111.
dc.identifier.citedreferenceCanli T, Cooney RE, Goldin P, Shah M, Sivers H, Thomason ME, Whitfieldâ Gabrieli S, Gabrieli JDE, Gotlib IH. 2005a. Amygdala reactivity to emotional faces predicts improvement in major depression. Neuroreport 16: 1267 â 1270.
dc.identifier.citedreferenceCanli T, Omura K, Haas BW, Fallgatter A, Constable RT, Lesch KP. 2005b. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc Natl Acad Sci U S A 102: 12224 â 12229.
dc.identifier.citedreferenceCanli T, Congdon E, Gutknecht L, Constable RT, Lesch KP. 2005c. Amygdala responsiveness is modulated by tryptophan hydroxylaseâ 2 gene variation. J Neural Transm 112: 1479 â 1485.
dc.identifier.citedreferenceCanli T, Congdon E, Todd Constable R, Lesch KP. 2008. Additive effects of serotonin transporter and tryptophan hydroxylaseâ 2 gene variation on neural correlates of affective processing. Biol Psychol 79: 118 â 125.
dc.identifier.citedreferenceCarli V, Mandelli L, Zaninotto L, Roy A, Recchia L, Stoppia L, Gatta V, Sarchiapone M, Serretti A. 2011. A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a highâ risk population. Eur Psychiatry 26: 471 â 478.
dc.identifier.citedreferenceCarrel L, Willard HF. 2005. Xâ inactivation profile reveals extensive variability in Xâ linked gene expression in females. Nature 434: 400 â 404.
dc.identifier.citedreferenceCases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih JC. 1995. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268: 1763 â 1766.
dc.identifier.citedreferenceCaspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. 2002. Role of genotype in the cycle of violence in maltreated children. Science 297: 851 â 854.
dc.identifier.citedreferenceCaspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. 2003. Influence of life stress on depression: moderation by a polymorphism in the 5â HTT gene. Science 301: 386 â 389.
dc.identifier.citedreferenceCenter for Behavioral Health Statistics and Quality. 2015. Behavioral health trends in the United States: Results from the 2014 National Survey on Drug Use and Health. HHS Publication No. SMA 15â 4927, NSDUH Series Hâ 50.
dc.identifier.citedreferenceCerasa A, Gioia MC, Fera F, Passamonti L, Liguori M, Lanza P, Muglia M, Magariello A, Quattrone A. 2008a. Ventroâ lateral prefrontal activity during working memory is modulated by MAO A genetic variation. Brain Res 1201: 114 â 121.
dc.identifier.citedreferenceCerasa A, Gioia MC, Labate A, Lanza P, Magariello A, Muglia M, Quattrone A. 2008b. MAO A VNTR polymorphism and variation in human morphology: a VBM study. Neuroreport 19: 1107 â 1110.
dc.identifier.citedreferenceCerasa A, Quattrone A, Gioia MC, Magariello A, Muglia M, Assogna F, Bernardini S, Caltagirone C, Bossù P, Spalletta G. 2011. MAO A VNTR polymorphism and amygdala volume in healthy subjects. Psychiatry Res 191: 87 â 91.
dc.identifier.citedreferenceCerasa A, Quattrone A, Piras F, Mangone G, Magariello A, Fagioli S, Girardi P, Muglia M, Caltagirone C, Spalletta G. 2014. 5â HTTLPR, anxiety and gender interaction moderates right amygdala volume in healthy subjects. Soc Cogn Affect Neurosci 9: 1537 â 1545.
dc.identifier.citedreferenceChen H, Pine DS, Ernst M, Gorodetsky E, Kasen S, Gordon K, Goldman D, Cohen D. 2013. The MAOA gene predicts happiness in women. Prog Neuropsychopharmacol Biol Psychiatry 40: 122 â 125.
dc.identifier.citedreferenceChu DA, Williams LM, Harris AWF, Bryant RA, Gatt JM. 2013. Early life trauma predicts selfâ reported levels of depressive and anxiety symptoms in nonclinical community adults: relative contributions of earlyâ life stressor types and adult trauma exposure. J Psychiatr Res 47: 23 â 32.
dc.identifier.citedreferenceCicchetti D, Rogosch FA, Sturgeâ Apple M. 2007. Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from low socioeconomic status backgrounds. Dev Psychopathol 19: 1161 â 1180.
dc.identifier.citedreferenceClemens B, Voà B, Pawliczek C, Mingoia G, Weyer D, Repple J, Eggermann T, Zerres K, Reetz K, Habel U. 2015. Effect of MAOA genotype on restingâ state networks in healthy participants. Cereb Cortex 25: 1771 â 1781.
dc.identifier.citedreferenceCosta P Jr, Terracciano A, McCrae RR. 2001. Gender differences in personality traits across cultures: robust and surprising findings. J Pers Soc Psychol 81: 322 â 331.
dc.identifier.citedreferenceCourtet P, Baud P, Abbar M, Boulenger JP, Castelnau D, Mouthon D, Malafosse A, Buresi C. 2001. Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene. Mol Psychiatry 6: 338 â 341.
dc.identifier.citedreferenceDannlowski U, Ohrmann P, Bauer J, Kugel H, Baune BT, Hohoff C, Kersting A, Arolt V, Heindel W, Deckert J, Suslow T. 2007. Serotonergic genes modulate amygdala activity in major depression. Genes Brain Behav 6: 672 â 676.
dc.identifier.citedreferenceDannlowski U, Ohrmann P, Bauer J, Deckert J, Hohoff C, Kugel H, Arolt V, Heindel W, Kersting A, Baune BT, Suslow T. 2008. 5â HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology 33: 418 â 424.
dc.identifier.citedreferenceDannlowski U, Ohrmann P, Konrad C, Domschke K, Bauer J, Kugel H, Hohoff C, Schöning S, Kersting A, Baune BT, Mortensen LS, Arolt V, Zwitserlood P, Deckert J, Heindel W, Suslow T. 2009. Reduced amygdalaâ prefrontal coupling in major depression: association with MAOA genotype and illness severity. Int J Neuropsychopharmacol 12: 11 â 22.
dc.identifier.citedreferenceDe Vries GJ. 2004. Minireview: Sex differences in adult and developing brains: compensation, compensation, compensation. Endocrinology 145: 1063 â 1068.
dc.identifier.citedreferenceDeckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nöthen MM, Maffei P, Franke P, Fritze J, Maier W, Propping P, Beckmann H, Bellodi L, Lesch KP. 1999. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8: 621 â 624.
dc.identifier.citedreferenceDenson TF, Dobsonâ Stone C, Ronay R, von Hippel W, Schira MM. 2014. A functional polymorphism of the MAOA gene is associated with neural responses to induced anger control. J Cogn Neurosci 26: 1418 â 1427.
dc.identifier.citedreferenceDerringer J, Krueger RF, Irons DE, Iacono WG. 2010. Harsh discipline, childhood sexual assault, and MAOA genotype: an investigation of main and interactive effects on diverse clinical externalizing outcomes. Behav Genet 40: 639 â 648.
dc.identifier.citedreferenceDomschke K, Tidow N, Kuithan H, Schwarte K, Klauke B, Ambrée O, Reif A, Schmidt H, Arolt V, Kersting A, Zwanzger P, Deckert J. 2012. Monoamine oxidase A gene DNA hypomethylationâ a risk factor for panic disorder? Int J Neuropsychopharmacol 15: 1217 â 1228.
dc.identifier.citedreferenceDouglas K, Chan G, Gelernter J, Arias AJ, Anton RF, Poling J, Farrer L, Kranzler HR. 2011. 5â HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder. Psychiatr Genet 21: 240 â 248.
dc.identifier.citedreferenceDrabant EM, Ramel W, Edge MD, Hyde LW, Kuo JR, Goldin PR, Hariri AR, Gross JJ. 2012. Neural mechanisms underlying 5â HTTLPRâ related sensitivity to acute stress. Am J Psychiatry 169: 397 â 405.
dc.identifier.citedreferenceDrevets WC. 2000. Neuroimaging studies of mood disorders. Biol Psychiatry 48: 813 â 829.
dc.identifier.citedreferenceDu L, Faludi G, Palkovits M, Demeter E, Bakish D, Lapierre YD, Sótonyi P, Hrdina PD. 1999. Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. Biol Psychiatry 46: 196 â 201.
dc.identifier.citedreferenceDu L, Bakish D, Hrdina PD. 2000. Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatr Genet 10: 159 â 164.
dc.identifier.citedreferenceDu L, Faludi G, Palkovits M, Sotonyi P, Bakish D, Hrdina PD. 2002. High activityâ related allele of MAOâ A gene associated with depressed suicide in males. Neuroreport 13: 1195 â 1198.
dc.identifier.citedreferenceDucci F, Enoch M, Hodgkinson C, Xu K, Catena M, Robin RW, Goldman D. 2008. Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 13: 334 â 347.
dc.identifier.citedreferenceEaton NR, Keyes KM, Krueger RF, Balsis S, Skodol AE, Markon KE, Grant BF, Hasin DS. 2012. An invariant dimensional liability model of gender differences in mental disorder prevalence: evidence from a national sample. J Abnorm Psychol 121: 282 â 288.
dc.identifier.citedreferenceEdwards AC, Dodge KA, Latendresse SJ, Lansford JE, Bates JE, Pettit GS, Budde JP, Goate AM, Dick DM. 2010. MAOAâ uVNTR and early physical discipline interact to influence delinquent behavior. J Child Psychol Psychiatry 51: 679 â 687.
dc.identifier.citedreferenceEisenberger NI, Way BM, Taylor SE, Welch WT, Lieberman MD. 2007. Understanding genetic risk for aggression: clues from the brain’s response to social exclusion. Biol Psychiatry 61: 1100 â 1108.
dc.identifier.citedreferenceEker MC, Kitis O, Okur H, Eker OD, Ozan E, Isikli S, Akarsu N, Gonul AS. 2011. Smaller hippocampus volume is associated with short variant of 5â HTTLPR polymorphism in medicationâ free major depressive disorder patients. Neuropsychobiology 63: 22 â 28.
dc.identifier.citedreferenceEley TC, Tahir E, Angleitner A, Harriss K, McClay J, Plomin R, Riemann R, Spinath F, Craig I. 2003. Association analysis of MAOA and COMT with neuroticism assessed by peers. Am J Med Genet B Neuropsychiatr Genet 120B: 90 â 96.
dc.identifier.citedreferenceEley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, Plomin R, Craig IW. 2004. Geneâ environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 9: 908 â 915.
dc.identifier.citedreferenceElâ Hage W, Zelaya F, Radua J, Gohier B, Alsop DC, Phillips ML, Surguladze SA. 2013. Restingâ state cerebral blood flow in amygdala is modulated by sex and serotonin transporter genotype. Neuroimage 76: 90 â 97.
dc.identifier.citedreferenceEnoch M, Steer CD, Newman TK, Gibson N, Goldman D. 2010. Early life stress, MAOA, and geneâ environment interactions predict behavioral disinhibition in children. Genes Brain Behav 9: 65 â 74.
dc.identifier.citedreferenceEveraerd D, Gerritsen L, Rijpkema M, Frodl T, van Oostrom I, Franke B, Fernández G, Tendolkar I. 2012. Sex modulates the interactive effect of the serotonin transporter gene polymorphism and childhood adversity on hippocampal volume. Neuropsychopharmacology 37: 1848 â 1855.
dc.identifier.citedreferenceFan J, Fossella J, Sommer T, Wu Y, Posner MI. 2003. Mapping the genetic variation of executive attention onto brain activity. Proc Natl Acad Sci U S A 100: 7406 â 7411.
dc.identifier.citedreferenceFasching PA, Faschingbauer F, Goecke TW, Engel A, Häberle L, Seifert A, Voigt F, Amann M, Rebhan D, Burger P, Kornhuber J, Ekici AB, Beckmann MW, Binder EB. 2012. Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy. J Psychiatr Res 46: 1109 â 1117.
dc.identifier.citedreferenceFawcett J, Busch KA, Jacobs D, Kravitz HM, Fogg L. 1997. Suicide: a fourâ pathway clinicalâ biochemical model. Ann N Y Acad Sci 836: 288 â 301.
dc.identifier.citedreferenceFlory JD, Manuck SB, Ferrell RE, Dent KM, Peters DG, Muldoon MF. 1999. Neuroticism is not associated with the serotonin transporter (5â HTTLPR) polymorphism. Mol Psychiatry 4: 93 â 96.
dc.identifier.citedreferenceFoley DL, Eaves LJ, Wormley B. 2004. Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder. Arch Gen Psychiatry 61: 738 â 744.
dc.identifier.citedreferenceFortier E, Noreau A, Lepore F, Boivin M, Pérusse D, Rouleau GA, Beauregard M. 2010. Early impact of 5â HTTLPR polymorphism on the neural correlates of sadness. Neurosci Lett 485: 261 â 265.
dc.identifier.citedreferenceFrazzetto G, Lorenzo GD, Carola V, Proietti L, Sokolowska E, Siracusano A, Gross C, Troisi A. 2007. Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. PLoS One 2: e486.
dc.identifier.citedreferenceFrodl T, Zill P, Baghai T, Schüle C, Rupprecht R, Zetzsche T, Bondy B, Reiser M, Möller H, Meisenzahl EM. 2008. Reduced hippocampal volumes associated with the long variant of the triâ and diallelic serotonin transporter polymorphism in major depression. Am J Med Genet B Neuropsychiatr Genet 147B: 1003 â 1007.
dc.identifier.citedreferenceFrodl T, Reinhold E, Koutsouleris N, Donohoe G, Bondy B, Reiser M, Möller H, Meisenzahl EM. 2010. Childhood stress, serotonin transporter gene and brain structures in major depression. Neuropsychopharmacology 35: 1383 â 1390.
dc.identifier.citedreferenceFurman DJ, Hamilton JP, Joormann J, Gotlib IH. 2011. Altered timing of amygdala activation during sad mood elaboration as a function of 5â HTTLPR. Soc Cogn Affect Neurosci 6: 270 â 276.
dc.identifier.citedreferenceFurmark T, Tillfors M, Garpenstrand H, Marteinsdottir I, LÃ¥ngström B, Oreland L, Fredrikson M. 2004. Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neurosci Lett 362: 189 â 192.
dc.identifier.citedreferenceFurmark T, Henningsson S, Appel L, Ahs F, Linnman C, Pissiota A, Faria V, Oreland L, Bani M, Pich EM, Eriksson E, Fredrikson M. 2009. Genotype overdiagnosis in amygdala responsiveness: affective processing in social anxiety disorder. J Psychiatry Neurosci 34: 30 â 40.
dc.identifier.citedreferenceGalfalvy H, Huang Y, Oquendo MA, Currier D, Mann JJ. 2009. Increased risk of suicide attempt in mood disorders and TPH1 genotype. J Affect Disord 115: 331 â 338.
dc.identifier.citedreferenceGao J, Pan Z, Jiao Z, Li F, Zhao G, Wei Q, Pan F, Evangelou E. 2012. TPH2 gene polymorphisms and major depressionâ a metaâ analysis. PLoS One 7: e36721.
dc.identifier.citedreferenceGaspar P, Cases O, Maroteaux L. 2003. The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4: 1002 â 1012.
dc.identifier.citedreferenceGaysina D, Zainullina A, Gabdulhakov R, Khusnutdinova E. 2006. The serotonin transporter gene: polymorphism and haplotype analysis in Russian suicide attempters. Neuropsychobiology 54: 70 â 74.
dc.identifier.citedreferenceGelernter J, Kranzler H, Coccaro EF, Siever LJ, New AS. 1998. Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. Am J Psychiatry 155: 1332 â 1338.
dc.identifier.citedreferenceGillihan SJ, Rao H, Brennan L, Wang DJJ, Detre JA, Sankoorikal GMV, Brodkin ES, Farah MJ. 2011. Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults. Psychiatry Res 193: 161 â 167.
dc.identifier.citedreferenceGizatullin R, Zaboli G, Jönsson EG, Asberg M, Leopardi R. 2006. Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biol Psychiatry 59: 295 â 300.
dc.identifier.citedreferenceGoldstein ME, Tank AW, Fossom LH, Hamill RW. 1992. Molecular aspects of the regulation of tyrosine hydroxylase by testosterone. Brain Res Mol Brain Res 14: 79 â 86.
dc.identifier.citedreferenceGonda X, Juhasz G, Laszik A, Rihmer Z, Bagdy G. 2005. Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene. J Affect Disord 87: 291 â 297.
dc.identifier.citedreferenceGonzálezâ Castro TB, Juárezâ Rojop I, Lópezâ Narváez ML, Tovillaâ Zárate CA. 2014. Association of TPHâ 1 and TPHâ 2 gene polymorphisms with suicidal behavior: a systematic review and metaâ analysis. BMC Psychiatry 14: 196.
dc.identifier.citedreferenceGoodwin RD, Gotlib IH. 2004. Gender differences in depression: the role of personality factors. Psychiatry Res 126: 135 â 142.
dc.identifier.citedreferenceGorodetsky E, Bevilacqua L, Carli V, Sarchiapone M, Roy A, Goldman D, Enoch M. 2014. The interactive effect of MAOAâ LPR genotype and childhood physical neglect on aggressive behaviors in Italian male prisoners. Genes Brain Behav 13: 543 â 549.
dc.identifier.citedreferenceGorwood P, Batel P, Adès J, Hamon M, Boni C. 2000. Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry 48: 259 â 264.
dc.identifier.citedreferenceGotlib IH, Joormann J, Minor KL, Hallmayer J. 2008. HPA axis reactivity: a mechanism underlying the associations among 5â HTTLPR, stress, and depression. Biol Psychiatry 63: 847 â 851.
dc.identifier.citedreferenceGottfries CG, Roos BE, Winblad B. 1974. Determination of 5â hydroxytryptamine, 5â hydroxyindoleacetic acid, and homovanillic acid in brain tissue from an autopsy material. Acta Psychiatr Scand 50: 496 â 507.
dc.identifier.citedreferenceGrabe HJ, Lange M, Wolff B, Völzke H, Lucht M, Freyberger HJ, John U, Cascorbi I. 2005. Mental and physical distress is modulated by a polymorphism in the 5â HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatry 10: 220 â 224.
dc.identifier.citedreferenceGranger DA, Shirtcliff EA, Zahnâ Waxler C, Usher B, Klimesâ Dougan B, Hastings P. 2003. Salivary testosterone diurnal variation and psychopathology in adolescent males and females: individual differences and developmental effects. Dev Psychopathol 15: 431 â 449.
dc.identifier.citedreferenceGreenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL. 2000. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96: 202 â 216.
dc.identifier.citedreferenceGressier F, Calati R, Serretti A. 2016. 5â HTTLPR and gender differences in affective disorders: a systematic review. J Affect Disord 190: 193 â 207.
dc.identifier.citedreferenceGrochans E, Jurczak A, Szkup M, Samochowiec A, Wloszczakâ Szubzda A, Karakiewicz B, Grzywacz A, Brodowska A, Samochowiec J. 2015. Evaluation of the relationship between 5â HTT and MAO gene polymorphisms, mood and level of anxiety among postmenopausal women. Int J Environ Res Public Health 12: 268 â 281.
dc.identifier.citedreferenceGrohmann M, Hammer P, Walther M, Paulmann N, Büttner A, Eisenmenger W, Baghai TC, Schüle C, Rupprecht R, Bader M, Bondy B, Zill P, Priller J, Walther DJ. 2010. Alternative splicing and extensive RNA editing of human TPH2 transcripts. PLoS One 5: e8956.
dc.identifier.citedreferenceGundlah C, Lu NZ, Bethea CL. 2002. Ovarian steroid regulation of monoamine oxidaseâ A and B mRNAs in the macaque dorsal raphe and hypothalamic nuclei. Psychopharmacology 160: 271 â 282.
dc.identifier.citedreferenceGuo G, Ou X, Roettger M, Shih JC. 2008. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet 16: 626 â 634.
dc.identifier.citedreferenceGutknecht L, Jacob C, Strobel A, Kriegebaum C, Müller J, Zeng Y, Markert C, Escher A, Wendland J, Reif A, Mössner R, Gross C, Brocke B, Lesch K. 2007. Tryptophan hydroxylaseâ 2 gene variation influences personality traits and disorders related to emotional dysregulation. Int J Neuropsychopharmacol 10: 309 â 320.
dc.identifier.citedreferenceGutknecht L, Popp S, Waider J, Sommerlandt FMJ, Göppner C, Post A, Reif A, van den Hove D, Strekalova T, Schmitt A, ColaÏ o MBN, Sommer C, Palme R, Lesch K. 2015. Interaction of brain 5â HT synthesis deficiency, chronic stress, and sex differentially impact emotional behavior in Tph2 knockout mice. Psychopharmacology 232: 2429 â 2441.
dc.identifier.citedreferenceHaberstick BC, Smolen A, Hewitt JK. 2006. Familyâ based association test of the 5HTTLPR and aggressive behavior in a general population sample of children. Biol Psychiatry 59: 836 â 843.
dc.identifier.citedreferenceHallikainen T, Saito T, Lachman HM, Volavka J, Pohjalainen T, Ryynänen OP, Kauhanen J, Syvälahti E, Hietala J, Tiihonen J. 1999. Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Mol Psychiatry 4: 385 â 388.
dc.identifier.citedreferenceHammen C, Brennan PA, Keenanâ Miller D, Hazel NA, Najman JM. 2010. Chronic and acute stress, gender, and serotonin transporter geneâ environment interactions predicting depression symptoms in youth. J Child Psychol Psychiatry 51: 180 â 187.
dc.identifier.citedreferenceHariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR. 2002. Serotonin transporter genetic variation and the response of the human amygdala. Science 297: 400 â 403.
dc.identifier.citedreferenceHariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR. 2005. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62: 146 â 152.
dc.identifier.citedreferenceHeim C, Binder EB. 2012. Current research trends in earlyâ life stress and depression: review of human studies on sensitive periods, geneâ environment interactions, and epigenetics. Exp Neurol 233: 102 â 111.
dc.identifier.citedreferenceHeim C, Nemeroff CB. 2001. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49: 1023 â 1039.
dc.identifier.citedreferenceHeinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grüsser SM, Flor H, Schumann G, Mann K, Büchel C. 2005. Amygdalaâ prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 8: 20 â 21.
dc.identifier.citedreferenceHeinz A, Smolka MN, Braus DF, Wrase J, Beck A, Flor H, Mann K, Schumann G, Büchel C, Hariri AR, Weinberger DR. 2007. Serotonin transporter genotype (5â HTTLPR): effects of neutral and undefined conditions on amygdala activation. Biol Psychiatry 61: 1011 â 1014.
dc.identifier.citedreferenceHermann A, Küpper Y, Schmitz A, Walter B, Vaitl D, Hennig J, Stark R, Tabbert K. 2012. Functional gene polymorphisms in the serotonin system and traumatic life events modulate the neural basis of fear acquisition and extinction. PLoS One 7: e44352.
dc.identifier.citedreferenceHerrmann MJ, Huter T, Müller F, Mühlberger A, Pauli P, Reif A, Renner T, Canli T, Fallgatter AJ, Lesch K. 2007. Additive effects of serotonin transporter and tryptophan hydroxylaseâ 2 gene variation on emotional processing. Cereb Cortex 17: 1160 â 1163.
dc.identifier.citedreferenceHiroi R, Handa RJ. 2013. Estrogen receptorâ β regulates human tryptophan hydroxylaseâ 2 through an estrogen response element in the 5â ² untranslated region. J Neurochem 127: 487 â 495.
dc.identifier.citedreferenceHiroi R, McDevitt RA, Neumaier JF. 2006. Estrogen selectively increases tryptophan hydroxylaseâ 2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Biol Psychiatry 60: 288 â 295.
dc.identifier.citedreferenceHirschfeld RMA. 2001. The comorbidity of major depression and anxiety disorders: recognition and management in primary care. Prim Care Companion J Clin Psychiatry 3: 244 â 254.
dc.identifier.citedreferenceHolmes AJ, Bogdan R, Pizzagalli DA. 2010. Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression. Neuropsychopharmacology 35: 1186 â 1197.
dc.identifier.citedreferenceHolz N, Boecker R, Buchmann AF, Blomeyer D, Baumeister S, Hohmann S, Jennenâ Steinmetz C, Wolf I, Rietschel M, Witt SH, Plichta MM, Meyerâ Lindenberg A, Schmidt MH, Esser G, Banaschewski T, Brandeis D, Laucht M. 2016. Evidence for a sexâ dependent MAOAâ Ã â childhood stress interaction in the neural circuitry of aggression. Cereb Cortex 26: 904 â 914.
dc.identifier.citedreferenceHuang S, Lin M, Lin W, Huang C, Shy M, Lu R. 2009. Association of monoamine oxidase A (MAOA) polymorphisms and clinical subgroups of major depressive disorders in the Han Chinese population. World J Biol Psychiatry 10: 544 â 551.
dc.identifier.citedreferenceHuang Y, Cate SP, Battistuzzi C, Oquendo MA, Brent D, Mann JJ. 2004. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits, and early abuse experiences. Neuropsychopharmacology 29: 1498 â 1505.
dc.identifier.citedreferenceHung C, Lung F, Chen C, O’Nions E, Hung T, Chong M, Wu C, Wen J, Lin P. 2011. Association between suicide attempt and a triallelic functional polymorphism in serotonin transporter gene promoter in Chinese patients with schizophrenia. Neurosci Lett 504: 242 â 246.
dc.identifier.citedreferenceIng NH. 2005. Steroid hormones regulate gene expression posttranscriptionally by altering the stabilities of messenger RNAs. Biol Reprod 72: 1290 â 1296.
dc.identifier.citedreferenceInoue H, Yamasue H, Tochigi M, Takei K, Suga M, Abe O, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K. 2010. Effect of tryptophan hydroxylaseâ 2 gene variants on amygdalar and hippocampal volumes. Brain Res 1331: 51 â 57.
dc.identifier.citedreferenceJabbi M, Korf J, Kema IP, Hartman C, van der Pompe G, Minderaa RB, Ormel J, den Boer JA. 2007. Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5â HTT, COMT, and MAOA. Mol Psychiatry 12: 483 â 490.
dc.identifier.citedreferenceJacobs N, Kenis G, Peeters F, Derom C, Vlietinck R, van Os J. 2006. Stressâ related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 63: 989 â 996.
dc.identifier.citedreferenceJaworska N, MacMaster FP, Foster J, Ramasubbu R. 2016. The influence of 5â HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study. BMC Psychiatry 16: 61.
dc.identifier.citedreferenceJoffe H, Cohen LS. 1998. Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge? Biol Psychiatry 44: 798 â 811.
dc.identifier.citedreferenceJokela M, Räikkönen K, Lehtimäki T, Rontu R, Keltikangasâ Järvinen L. 2007. Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults. J Affect Disord 100: 191 â 197.
dc.identifier.citedreferenceJönsson EG, Goldman D, Spurlock G, Gustavsson JP, Nielsen DA, Linnoila M, Owen MJ, Sedvall GC. 1997. Tryptophan hydroxylase and catecholâ Oâ methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Eur Arch Psychiatry Clin Neurosci 247: 297 â 302.
dc.identifier.citedreferenceJönsson EG, Norton N, Gustavsson JP, Oreland L, Owen MJ, Sedvall GC. 2000. A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers. J Psychiatr Res 34: 239 â 244.
dc.identifier.citedreferenceJovanovic H, Lundberg J, Karlsson P, Cerin à , Saijo T, Varrone A, Halldin C, Nordström A. 2008. Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET. Neuroimage 39: 1408 â 1419.
dc.identifier.citedreferenceKarg K, Burmeister M, Shedden K, Sen S. 2011. The serotonin transporter promoter variant (5â HTTLPR), stress, and depression metaâ analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 68: 444 â 454.
dc.identifier.citedreferenceKatsuragi S, Kunugi H, Sano A, Tsutsumi T, Isogawa K, Nanko S, Akiyoshi J. 1999. Association between serotonin transporter gene polymorphism and anxietyâ related traits. Biol Psychiatry 45: 368 â 370.
dc.identifier.citedreferenceKe L, Qi ZY, Ping Y, Ren CY. 2006. Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide. Brain Res 1122: 24 â 26.
dc.identifier.citedreferenceKeltikangasâ Järvinen L, Puttonen S, Kivimäki M, Elovainio M, Rontu R, Lehtimäki T. 2007. Tryptophan hydroxylase 1 gene haplotypes modify the effect of a hostile childhood environment on adulthood harm avoidance. Genes Brain Behav 6: 305 â 313.
dc.identifier.citedreferenceKendler KS, Gatz M, Gardner CO, Pedersen NL. 2006. A Swedish national twin study of lifetime major depression. Am J Psychiatry 163: 109 â 114.
dc.identifier.citedreferenceKessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. 1993. Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity, and recurrence. J Affect Disord 29: 85 â 96.
dc.identifier.citedreferenceKim Y, Lee H, Yang J, Hwang J, Yoon H. 2009. A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. Behav Genet 39: 170 â 175.
dc.identifier.citedreferenceKimâ Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE. 2006. MAOA, maltreatment, and geneâ environment interaction predicting children’s mental health: new evidence and a metaâ analysis. Mol Psychiatry 11: 903 â 913.
dc.identifier.citedreferenceKinnally EL, Huang Y, Haverly R, Burke AK, Galfalvy H, Brent DP, Oquendo MA, Mann JJ. 2009. Parental care moderates the influence of MAOAâ uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women. Psychiatr Genet 19: 126 â 133.
dc.identifier.citedreferenceKlucken T, Alexander N, Schweckendiek J, Merz CJ, Kagerer S, Osinsky R, Walter B, Vaitl D, Hennig J, Stark R. 2013a. Individual differences in neural correlates of fear conditioning as a function of 5â HTTLPR and stressful life events. Soc Cogn Affect Neurosci 8: 318 â 325.
dc.identifier.citedreferenceKlucken T, Wehrum S, Schweckendiek J, Merz CJ, Hennig J, Vaitl D, Stark R. 2013b. The 5â HTTLPR polymorphism is associated with altered hemodynamic responses during appetitive conditioning. Hum Brain Mapp 34: 2549 â 2560.
dc.identifier.citedreferenceKlucken T, Schweckendiek J, Blecker C, Walter B, Kuepper Y, Hennig J, Stark R. 2015. The association between the 5â HTTLPR and neural correlates of fear conditioning and connectivity. Soc Cogn Affect Neurosci 10: 700 â 707.
dc.identifier.citedreferenceKobiella A, Reimold M, Ulshöfer DE, Ikonomidou VN, Vollmert C, Vollstädtâ Klein S, Rietschel M, Reischl G, Heinz A, Smolka MN. 2011. How the serotonin transporter 5â HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure. Transl Psychiatry 1: e37.
dc.identifier.citedreferenceKoh KB, Kim CH, Choi EH, Lee Y, Seo WY. 2012. Effect of tryptophan hydroxylase gene polymorphism on aggression in major depressive disorder and undifferentiated somatoform disorder. J Clin Psychiatry 73: e574 â 579.
dc.identifier.citedreferenceKornstein SG, Schatzberg AF, Thase ME, Yonkers KA, McCullough JP, Keitner GI, Gelenberg AJ, Davis SM, Harrison WM, Keller MB. 2000. Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry 157: 1445 â 1452.
dc.identifier.citedreferenceKranz GS, Wadsak W, Kaufmann U, Savli M, Baldinger P, Gryglewski G, Haeusler D, Spies M, Mitterhauser M, Kasper S, Lanzenberger R. 2015. Highâ dose testosterone treatment increases serotonin transporter binding in transgender people. Biol Psychiatry 78: 525 â 533.
dc.identifier.citedreferenceKuepper Y, Grant P, Wielpuetz C, Hennig J. 2013. MAOAâ uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation. Behav Brain Res 247: 73 â 78.
dc.identifier.citedreferenceLee B, Ham B. 2008a. Monoamine oxidase Aâ uVNTR genotype affects limbic brain activity in response to affective facial stimuli. Neuroreport 19: 515 â 519.
dc.identifier.citedreferenceLee B, Ham B. 2008b. Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes Brain Behav 7: 899 â 905.
dc.identifier.citedreferenceLee B, Lee H, Lee B, Pae C, Yoon B, Ryu S, Choi I, Lee M, Ham B. 2009. Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder. Genes Brain Behav 8: 512 â 518.
dc.identifier.citedreferenceLee KY, Jeong SH, Kim SH, Ahn YM, Kim YS, Jung HY, Bang YW, Joo E. 2014. Genetic role of BDNF Val66Met and 5â HTTLPR polymorphisms on depressive disorder. Psychiatry Investig 11: 192 â 199.
dc.identifier.citedreferenceLehto K, Vaht M, Mäestu J, Veidebaum T, Harro J. 2015. Effect of tryptophan hydroxylaseâ 2 gene polymorphism Gâ 703â T on personality in a population representative sample. Prog Neuropsychopharmacol Biol Psychiatry 57: 31 â 35.
dc.identifier.citedreferenceLei H, Zhang X, Di X, Rao H, Ming Q, Zhang J, Guo X, Jiang Y, Gao Y, Yi J, Zhu X, Yao S. 2014. A functional polymorphism of the MAOA gene modulates spontaneous brain activity in pons. Biomed Res Int 2014: 243280.
dc.identifier.citedreferenceLemogne C, Gorwood P, Boni C, Pessiglione M, Lehéricy S, Fossati P. 2011. Cognitive appraisal and life stress moderate the effects of the 5â HTTLPR polymorphism on amygdala reactivity. Hum Brain Mapp 32: 1856 â 1867.
dc.identifier.citedreferenceLesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL. 1996. Association of anxietyâ related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527 â 1531.
dc.identifier.citedreferenceLi D, He L. 2006. Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic metaâ analyses. Hum Genet 119: 233 â 240.
dc.identifier.citedreferenceLi JJ, Lee SS. 2010. Latent class analysis of antisocial behavior: interaction of serotonin transporter genotype and maltreatment. J Abnorm Child Psychol 38: 789 â 801.
dc.identifier.citedreferenceLi JJ, Berk MS, Lee SS. 2013. Differential susceptibility in longitudinal models of geneâ environment interaction for adolescent depression. Dev Psychopathol 25: 991 â 1003.
dc.identifier.citedreferenceLimosin F, Loze J, Boni C, Hamon M, Adès J, Rouillon F, Gorwood P. 2005. Maleâ specific association between the 5â HTTLPR S allele and suicide attempts in alcoholâ dependent subjects. J Psychiatr Res 39: 179 â 182.
dc.identifier.citedreferenceLin YJ, Ko H, Chang F, Yeh T, Sun HS. 2009. Populationâ specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Arch Womens Ment Health 12: 401 â 408.
dc.identifier.citedreferenceLittle K, Olsson CA, Whittle S, Youssef GJ, Byrne ML, Simmons JG, Yücel M, Foley DL, Allen NB. 2014. Association between serotonin transporter genotype, brain structure and adolescentâ onset major depressive disorder: a longitudinal prospective study. Transl Psychiatry 4: e445.
dc.identifier.citedreferenceLiu J, Mo Y, Ge T, Wang Y, Luo X, Feng J, Li M, Su B. 2015. Allelic variation at 5â HTTLPR is associated with brain morphology in a Chinese population. Psychiatry Res 226: 399 â 402.
dc.identifier.citedreferenceLiu Y, Lu Z. 2013. The Relationship between MAOA gene polymorphism and test anxiety. Twin Res Hum Genet 16: 1103 â 1106.
dc.identifier.citedreferenceLoi M, Koricka S, Lucassen PJ, Joëls M. 2014. Ageâ and sexâ dependent effects of earlyâ life stress on hippocampal neurogenesis. Front Endocrinol 5: 13.
dc.identifier.citedreferenceLopez de Lara C, Brezo J, Rouleau G, Lesage A, Dumont M, Alda M, Benkelfat C, Turecki G. 2007. Effect of tryptophan hydroxylaseâ 2 gene variants on suicide risk in major depression. Biol Psychiatry 62: 72 â 80.
dc.identifier.citedreferenceLothe A, Boni C, Costes N, Gorwood P, Bouvard S, Le Bars D, Lavenne F, Ryvlin P. 2009. Association between triallelic polymorphism of the serotonin transporter and [18F]MPPF binding potential at 5â HT1A receptors in healthy subjects. Neuroimage 47: 482 â 492.
dc.identifier.citedreferenceLung F, Tzeng D, Huang M, Lee M. 2011. Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder. BMC Med Genet 12: 74.
dc.identifier.citedreferenceMa J, Xiao H, Yang Y, Cao D, Wang L, Yang X, Qiu X, Qiao Z, Song J, Liu Y, Wang P, Zhou J, Zhu X. 2015. Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population. J Affect Disord 188: 304 â 309.
dc.identifier.citedreferenceMandelli L, Antypa N, Nearchou FA, Vaiopoulos C, Stefanis CN, Serretti A, Stefanis NC. 2012. The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism. J Affect Disord 142: 82 â 89.
dc.identifier.citedreferenceMann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. 1997. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am J Psychiatry 10: 1451 â 1453.
dc.identifier.citedreferenceManuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. 1999. Aggression and angerâ related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 45: 603 â 614.
dc.identifier.citedreferenceManuck SB, Flory JD, Ferrell RE, Mann JJ, Muldoon MF. 2000. A regulatory polymorphism of the monoamine oxidaseâ A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 95: 9 â 23.
dc.identifier.citedreferenceMarkus CR, De Raedt R. 2011. Differential effects of 5â HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and tryptophan challenge. Neuropsychopharmacology 36: 819 â 826.
dc.identifier.citedreferenceMaron E, Tasa G, Tõru I, Lang A, Vasar V, Shlik J. 2004. Association between serotoninâ related genetic polymorphisms and CCKâ 4â induced panic attacks with or without 5â hydroxytryptophan pretreatment in healthy volunteers. World J Biol Psychiatry 5: 149 â 154.
dc.identifier.citedreferenceMaron E, Lang A, Tasa G, Liivlaid L, Tõru I, Must A, Vasar V, Shlik J. 2005. Associations between serotoninâ related gene polymorphisms and panic disorder. Int J Neuropsychopharmacol 8: 261 â 266.
dc.identifier.citedreferenceMaron E, Tõru I, Must A, Tasa G, Toover E, Vasar V, Lang A, Shlik J. 2007. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Neurosci Lett 411: 180 â 184.
dc.identifier.citedreferenceMarriage K, Fine S, Moretti M, Haley G. 1986. Relationship between depression and conduct disorder in children and adolescents. J Am Acad Child Psychiatry 25: 687 â 691.
dc.identifier.citedreferenceMazzanti CM, Lappalainen J, Long JC, Bengel D, Naukkarinen H, Eggert M, Virkkunen M, Linnoila M, Goldman D. 1998. Role of the serotonin transporter promoter polymorphism in anxietyâ related traits. Arch Gen Psychiatry 55: 936 â 940.
dc.identifier.citedreferenceMcCaffery JM, Bleil M, Pogueâ Geile M, Ferrell RE, Manuck SB. 2003. Allelic variation in the serotonin transporter geneâ linked polymorphic region (5â HTTLPR) and cardiovascular reactivity in young adult male and female twins of Europeanâ American descent. Psychosom Med 65: 721 â 728.
dc.identifier.citedreferenceMcGuffin P, Perroud N, Uher R, Butler A, Aitchison KJ, Craig I, Lewis C, Farmer A. 2010. The genetics of affective disorder and suicide. Eur Psychiatry 25: 275 â 277.
dc.identifier.citedreferenceMcHenry J, Carrier N, Hull E, Kabbaj M. 2014. Sex differences in anxiety and depression: role of testosterone. Front Neuroendocrinol 35: 42 â 57.
dc.identifier.citedreferenceMcLean CP, Asnaani A, Litz BT, Hofmann SG. 2011. Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res 45: 1027 â 1035.
dc.identifier.citedreferenceMcQueen JK, Wilson H, Fink G. 1997. Estradiolâ 17β increase serotonin transporter (SERT) mRNA levels and the density of SERTâ binding sites in female rat brain. Mol Brain Res 45: 13 â 23.
dc.identifier.citedreferenceMelas PA, Wei Y, Wong CCY, Sjöholm LK, à berg E, Mill J, Schalling M, Forsell Y, Lavebratt C. 2013. Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. Int J Neuropsychopharmacol 16: 1513 â 1528.
dc.identifier.citedreferenceMelke J, Landén M, Baghei F, Rosmond R, Holm G, Björntorp P, Westberg L, Hellstrand M, Eriksson E. 2001. Serotonin transporter gene polymorphisms are associated with anxietyâ related personality traits in women. Am J Med Genet 105: 458 â 463.
dc.identifier.citedreferenceMeyerâ Lindenberg A, Buckholtz JW, Kolachana B, Hariri AR, Pezawas L, Blasi G, Wabnitz A, Honea R, Verchinski B, Callicott JH, Egan M, Mattay V, Weinberger DR. 2006. Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A 103: 6269 â 6274.
dc.identifier.citedreferenceMickey BJ, Ducci F, Hodgkinson CA, Langenecker SA, Goldman D, Zubieta J. 2008. Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo. J Neurosci 28: 11354 â 11359.
dc.identifier.citedreferenceMigeon BR. 2007. Why females are mosaics, Xâ chromosome inactivation, and sex differences in disease. Gend Med 4: 97 â 105.
dc.identifier.citedreferenceMing Q, Zhang Y, Chai Q, Chen H, Hou C, Wang M, Wang Y, Cai L, Zhu X, Yi J, Yao S. 2013. Interaction between a serotonin transporter gene promoter region polymorphism and stress predicts depressive symptoms in Chinese adolescents: a multiwave longitudinal study. BMC Psychiatry 13: 142.
dc.identifier.citedreferenceMing Q, Zhang Y, Yi J, Wang X, Zhu X, Yao S. 2015. Serotonin transporter gene polymorphism (5â HTTLPR) L allele interacts with stress to increase anxiety symptoms in Chinese adolescents: a multiwave longitudinal study. BMC Psychiatry 15: 248.
dc.identifier.citedreferenceMizuno T, Aoki M, Shimada Y, Inoue M, Nakaya K, Takahashi T, Itoyama Y, Kanazawa M, Utsumi A, Endo Y, Nomura T, Hiratsuka M, Mizugaki M, Goto J, Hongo M, Fukudo S. 2006. Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety. J Psychosom Res 60: 91 â 97.
dc.identifier.citedreferenceMunafò MR, Clark T, Flint J. 2004. Does measurement instrument moderate the association between the serotonin transporter gene and anxietyâ related personality traits? A metaâ analysis. Mol Psychiatry 10: 415 â 419.
dc.identifier.citedreferenceMunafò MR, Brown SM, Hariri AR. 2008. Serotonin transporter (5â HTTLPR) genotype and amygdala activation: a metaâ analysis. Biol Psychiatry 63: 852 â 857.
dc.identifier.citedreferenceMunafò MR, Durrant C, Lewis G, Flint J. 2009. Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry 65: 211 â 219.
dc.identifier.citedreferenceNeumeister A, Konstantinidis A, Stastny J, Schwarz MJ, Vitouch O, Willeit M, Praschakâ Rieder N, Zach J, de Zwaan M, Bondy B, Ackenheil M, Kasper S. 2002. Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Arch Gen Psychiatry 59: 613 â 620.
dc.identifier.citedreferenceNew AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ. 1998. Tryptophan hydroxylase genotype is associated with impulsiveâ aggression measures: a preliminary study. Am J Med Genet 81: 13 â 17.
dc.identifier.citedreferenceNielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. 1994. Suicidality and 5â hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 51: 34 â 38.
dc.identifier.citedreferenceNielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M. 1998. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55: 593 â 602.
dc.identifier.citedreferenceNikolova Y, Bogdan R, Pizzagalli DA. 2011. Perception of a naturalistic stressor interacts with 5â HTTLPR/rs25531 genotype and gender to impact reward responsiveness. Neuropsychobiology 65: 45 â 54.
dc.identifier.citedreferenceNikulina V, Widom CS, Brzustowicz LM. 2012. Child abuse and neglect, MAOA, and mental health outcomes: a prospective examination. Biol Psychiatry 71: 350 â 357.
dc.identifier.citedreferenceNilsson KW, Sjöberg RL, Damberg M, Leppert J, Ohrvik J, Alm PO, Lindström L, Oreland L. 2006. Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity. Biol Psychiatry 59: 121 â 127.
dc.identifier.citedreferenceNilsson KW, Sjöberg RL, Wargelius H, Leppert J, Lindström L, Oreland L. 2007. The monoamine oxidase A (MAOâ A) gene, family function, and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption. Addiction 102: 389 â 398.
dc.identifier.citedreferenceNilsson KW, Wargelius H, Sjöberg RL, Leppert J, Oreland L. 2008. The MAOâ A gene, platelet MAOâ B activity, and psychosocial environment in adolescent female alcoholâ related problem behaviour. Drug Alcohol Depend 93: 51 â 62.
dc.identifier.citedreferenceNilsson KW, Comasco E, Ã slund C, Nordquist N, Leppert J, Oreland L. 2011. MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption. Addict Biol 16: 347 â 355.
dc.identifier.citedreferenceNilsson KW, Comasco E, Hodgins S, Oreland L, Ã slund C. 2015. Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: geneâ environment interactions of BDNF Val66Met, 5â HTTLPR, and MAOAâ uVNTR [corrected]. Int J Neuropsychopharmacol 18.
dc.identifier.citedreferenceNishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, de Montigny C, Blier P, Diksic M. 1997. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A 94: 5308 â 5313.
dc.identifier.citedreferenceNobile M, Rusconi M, Bellina M, Marino C, Giorda R, Carlet O, Vanzin L, Molteni M, Battaglia M. 2009. The influence of family structure, the TPH2â Gâ 703T and the 5â HTTLPR serotonergic genes upon affective problems in children aged 10â 14 years. J Child Psychol Psychiatry 50: 317 â 325.
dc.identifier.citedreferencePaaver M, Kurrikoff T, Nordquist N, Oreland L, Harro J. 2008. The effect of 5â HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Prog Neuropsychopharmacol Biol Psychiatry 32: 1263 â 1268.
dc.identifier.citedreferencePassamonti L, Fera F, Magariello A, Cerasa A, Gioia MC, Muglia M, Nicoletti G, Gallo O, Provinciali L, Quattrone A. 2006. Monoamine oxidaseâ a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity. Biol Psychiatry 59: 334 â 340.
dc.identifier.citedreferencePassamonti L, Cerasa A, Gioia MC, Magariello A, Muglia M, Quattrone A, Fera F. 2008. Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. Neuroimage 40: 1264 â 1273.
dc.identifier.citedreferencePerezâ Rodriguez M, Weinstein S, New AS, Bevilacqua L, Yuan Q, Zhou Z, Hodgkinson C, Goodman M, Koenigsberg HW, Goldman D, Siever LJ. 2010. Tryptophanâ hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. J Psychiatr Res 44: 1075 â 1081.
dc.identifier.citedreferencePezawas L, Meyerâ Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR. 2005. 5â HTTLPR polymorphism impacts human cingulateâ amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8: 828 â 834.
dc.identifier.citedreferencePorter RJ, Mulder RT, Joyce PR, Miller AL, Kennedy M. 2008. Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression. J Affect Disord 109: 209 â 212.
dc.identifier.citedreferencePreuss N, Salehi B, van der Veen JW, Shen J, Drevets WC, Hodgkinson C, Goldman D, Hasler G. 2013. Associations between prefrontal γâ aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women. Int J Neuropsychopharmacol 16: 1707 â 1717.
dc.identifier.citedreferencePrice JS, Strong J, Eliassen J, McQueeny T, Miller M, Padula CB, Shear P, Lisdahl K. 2013. Serotonin transporter gene moderates associations between mood, memory, and hippocampal volume. Behav Brain Res 242: 158 â 165.
dc.identifier.citedreferencePriessâ Groben H, Hyde JS. 2013. 5â HTTLPR X stress in adolescent depression: moderation by MAOA and gender. J Abnorm Child Psychol 41: 281 â 294.
dc.identifier.citedreferencePromâ Wormley E, Eaves LJ, Foley DL, Gardner CO, Archer KJ, Wormley BK, Maes HH, Riley BP, Silberg JL. 2009. Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females. Psychol Med 39: 579 â 590.
dc.identifier.citedreferencePuigâ Antich J. 1982. Major depression and conduct disorder in prepuberty. J Am Acad Child Psychiatry 21: 118 â 128.
dc.identifier.citedreferenceRabl U, Meyer BM, Diers K, Bartova L, Berger A, Mandorfer D, Popovic A, Scharinger C, Huemer J, Kalcher K, Pail G, Haslacher H, Perkmann T, Windischberger C, Brocke B, Sitte HH, Pollak DD, Dreher J, Kasper S, Praschakâ Rieder N, Moser E, Esterbauer H, Pezawas L. 2014. Additive geneâ environment effects on hippocampal structure in healthy humans. J Neurosci 34: 9917 â 9926.
dc.identifier.citedreferenceReif A, Rösler M, Freitag CM, Schneider M, Eujen A, Kissling C, Wenzler D, Jacob CP, Retzâ Junginger P, Thome J, Lesch K, Retz W. 2007. Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment. Neuropsychopharmacology 32: 2375 â 2383.
dc.identifier.citedreferenceReif A, Weber H, Domschke K, Klauke B, Baumann C, Jacob CP, Ströhle A, Gerlach AL, Alpers GW, Pauli P, Hamm A, Kircher T, Arolt V, Wittchen H, Binder EB, Erhardt A, Deckert J. 2012. Metaâ analysis argues for a femaleâ specific role of MAOAâ uVNTR in panic disorder in four European populations. Am J Med Genet B Neuropsychiatr Genet 159B: 786 â 793.
dc.identifier.citedreferenceReif A, Richter J, Straube B, Höfler M, Lueken U, Gloster AT, Weber H, Domschke K, Fehm L, Ströhle A, Jansen A, Gerlach A, Pyka M, Reinhardt I, Konrad C, Wittmann A, Pfleiderer B, Alpers GW, Pauli P, Lang T, Arolt V, Wittchen H, Hamm A, Kircher T, Deckert J. 2014. MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy. Mol Psychiatry 19: 122 â 128.
dc.identifier.citedreferenceReuter M, Kuepper Y, Hennig J. 2007. Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance. Int J Neuropsychopharmacol 10: 401 â 404.
dc.identifier.citedreferenceGorman JM. 2006. Gender differences in depression and response to psychotropic medication. Gend Med 3: 93 â 109.
dc.identifier.citedreferenceRivera M, Gutierrez B, Molina E, Torresâ Gonzalez F, Bellon JA, Morenoâ Kuestner B, King M, Nazareth I, Martinezâ Gonzalez L, Martinezâ Espin E, Munozâ Garcia M, Motrico E, Martinezâ Canavate T, Lorente JA, Luna JD, Cervilla JA. 2009. Highâ activity variants of the uMAOA polymorphism increase the risk for depression in a large primary care sample. Am J Med Genet B Neuropsychiatr Genet 150B: 395 â 402.
dc.identifier.citedreferenceRucci P, Nimgaonkar VL, Mansour H, Miniati M, Masala I, Fagiolini A, Cassano GB, Frank E. 2009. Gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression. Am J Med Genet B Neuropsychiatr Genet 150B: 907 â 913.
dc.identifier.citedreferenceRujescu D, Giegling I, Bondy B, Gietl A, Zill P, Möller H. 2002. Association of angerâ related traits with SNPs in the TPH gene. Mol Psychiatry 7: 1023 â 1029.
dc.identifier.citedreferenceRujescu D, Giegling I, Sato T, Hartmann AM, Möller HJ. 2003. Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and metaâ analysis. Biol Psychiatry 54: 465 â 473.
dc.identifier.citedreferenceSabol SZ, Hu S, Hamer D. 1998. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103: 273 â 279.
dc.identifier.citedreferenceSakado K, Sakado M, Muratake T, Mundt C, Someya T. 2003. A psychometrically derived impulsive trait related to a polymorphism in the serotonin transporter geneâ linked polymorphic region (5â HTTLPR) in a Japanese nonclinical population: assessment by the Barratt impulsiveness scale (BIS). Am J Med Genet B Neuropsychiatr Genet 121B: 71 â 75.
dc.identifier.citedreferenceSakai JT, Boardman JD, Gelhorn HL, Smolen A, Corley RP, Huizinga D, Menard S, Hewitt JK, Stallings MC. 2010. Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR). Psychiatr Genet 20: 199 â 206.
dc.identifier.citedreferenceSamochowiec J, Hajduk A, Samochowiec A, Horodnicki J, SÅ opieÅ G, Grzywacz A, Kucharskaâ Mazur J. 2004. Association studies of MAOâ A, COMT, and 5â HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Psychiatry Res 128: 21 â 26.
dc.identifier.citedreferenceScherk H, Gruber O, Menzel P, Schneiderâ Axmann T, Kemmer C, Usher J, Reith W, Meyer J, Falkai P. 2009. 5â HTTLPR genotype influences amygdala volume. Eur Arch Psychiatry Clin Neurosci 259: 212 â 217.
dc.identifier.citedreferenceSchinka JA, Busch RM, Robichauxâ Keene N. 2004. A metaâ analysis of the association between the serotonin transporter gene polymorphism (5â HTTLPR) and trait anxiety. Mol Psychiatry 9: 197 â 202.
dc.identifier.citedreferenceSchulze TG, Müller DJ, Krauss H, Scherk H, Ohlraun S, Syagailo YV, Windemuth C, Neidt H, Grässle M, Papassotiropoulos A, Heun R, Nöthen MM, Maier W, Lesch KP, Rietschel M. 2000. Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. Am J Med Genet 96: 801 â 803.
dc.identifier.citedreferenceSelvaraj S, Godlewska BR, Norbury R, Bose S, Turkheimer F, Stokes P, Rhodes R, Howes O, Cowen PJ. 2011. Decreased regional gray matter volume in Sâ allele carriers of the 5â HTTLPR triallelic polymorphism. Mol Psychiatry 16: 472 â 473.
dc.identifier.citedreferenceSen S, Burmeister M, Ghosh D. 2004. Metaâ analysis of the association between a serotonin transporter promoter polymorphism (5â HTTLPR) and anxietyâ related personality traits. Am J Med Genet B Neuropsychiatr Genet 127B: 85 â 89.
dc.identifier.citedreferenceSerretti A, Lilli R, Lorenzi C, Lattuada E, Cusin C, Smeraldi E. 2001. Tryptophan hydroxylase gene and major psychoses. Psychiatry Res 103: 79 â 86.
dc.identifier.citedreferenceSharpley CF, Palanisamy SKA, Glyde NS, Dillingham PW, Agnew LL. 2014. An update on the interaction between the serotonin transporter promoter variant (5â HTTLPR), stress, and depression, plus an exploration of nonconfirming findings. Behav Brain Res 273: 89 â 105.
dc.identifier.citedreferenceShen X, Wu Y, Qian M, Wang X, Hou Z, Liu Y, Sun J, Zhong H, Yang J, Lin M, Li L, Guan T, Shen Z, Yuan Y. 2011. Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population. J Affect Disord 133: 619 â 624.
dc.identifier.citedreferenceSjöberg RL, Nilsson KW, Nordquist N, Ohrvik J, Leppert J, Lindström L, Oreland L. 2006. Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol 9: 443 â 449.
dc.identifier.citedreferenceSjöberg RL, Nilsson KW, Wargelius H, Leppert J, Lindström L, Oreland L. 2007. Adolescent girls and criminal activity: role of MAOAâ LPR genotype and psychosocial factors. Am J Med Genet B Neuropsychiatr Genet 144B: 159 â 164.
dc.identifier.citedreferenceSÅ opieÅ R, SÅ opieÅ A, Różycka A, Warenikâ Szymankiewicz A, Lianeri M, JagodziÅ ski PP. 2012. The c.1460C>T polymorphism of MAOâ A is associated with the risk of depression in postmenopausal women. Sci World J 2012: 194845.
dc.identifier.citedreferenceSpalletta G, Piras F, Caltagirone C, Fagioli S. 2014. Hippocampal multimodal structural changes and subclinical depression in healthy individuals. J Affect Disord 152: 105 â 112.
dc.identifier.citedreferenceStaley JK, Sanacora G, Tamagnan G, Maciejewski PK, Malison RT, Berman RM, Vythilingam M, Kugaya A, Baldwin RM, Seibyl JP, Charney D, Innis RB. 2006. Sex differences in diencephalon serotonin transporter availability in major depression. Biol Psychiatry 59: 40 â 47.
dc.identifier.citedreferenceStaner L, Uyanik G, Correa H, Tremeau F, Monreal J, Crocq M, Stefos G, Morrisâ Rosendahl D, Macher JP. 2002. A dimensional impulsiveâ aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: a pilot study in wellâ characterized impulsive inpatients. Am J Med Genet 114: 553 â 557.
dc.identifier.citedreferenceStarcevic V, Uhlenhuth EH, Fallon S, Pathak D. 1996. Personality dimensions in panic disorder and generalized anxiety disorder. J Affect Disord 37: 75 â 79.
dc.identifier.citedreferenceStarr LR, Hammen C, Brennan PA, Najman JM. 2013. Relational security moderates the effect of serotonin transporter gene polymorphism (5â HTTLPR) on stress generation and depression among adolescents. J Abnorm Child Psychol 41: 379 â 388.
dc.identifier.citedreferenceSteffens DC, Svenson I, Marchuk DA, Levy RM, Hays JC, Flint EP, Krishnan KR, Siegler IC. 2002. Allelic differences in the serotonin transporterâ linked polymorphic region in geriatric depression. Am J Geriatr Psychiatry 10: 185 â 191.
dc.identifier.citedreferenceStein MB, Gorman JM. 2001. Unmasking social anxiety disorder. J Psychiatry Neurosci 26: 185 â 189.
dc.identifier.citedreferenceStein MB, Campbellâ Sills L, Gelernter J. 2009. Genetic variation in 5HTTLPR is associated with emotional resilience. Am J Med Genet B Neuropsychiatr Genet 150B: 900 â 906.
dc.identifier.citedreferenceStetler DA, Davis C, Leavitt K, Schriger I, Benson K, Bhakta S, Wang LC, Oben C, Watters M, Haghnegahdar T, Bortolato M. 2014. Association of lowâ activity MAOA allelic variants with violent crime in incarcerated offenders. J Psychiatr Res 58: 69 â 75.
dc.identifier.citedreferenceStoltenberg SF, Christ CC, Highland KB. 2012. Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner. Prog Neuropsychopharmacol Biol Psychiatry 39: 182 â 191.
dc.identifier.citedreferenceSullivan PF, Neale MC, Kendler KS. 2000. Genetic epidemiology of major depression: review and metaâ analysis. Am J Psychiatry 157: 1552 â 1562.
dc.identifier.citedreferenceSun HS, Tsai H, Ko H, Chang F, Yeh T. 2004. Association of tryptophan hydroxylase gene polymorphism with depression, anxiety, and comorbid depression and anxiety in a populationâ based sample of postpartum Taiwanese women. Genes Brain Behav 3: 328 â 336.
dc.identifier.citedreferenceSurguladze SA, Elkin A, Ecker C, Kalidindi S, Corsico A, Giampietro V, Lawrence N, Deeley Q, Murphy DGM, Kucharskaâ Pietura K, Russell TA, McGuffin P, Murray R, Phillips ML. 2008. Genetic variation in the serotonin transporter modulates neural systemâ wide response to fearful faces. Genes Brain Behav 7: 543 â 551.
dc.identifier.citedreferenceTadic A, Rujescu D, Szegedi A, Giegling I, Singer P, Möller H, Dahmen N. 2003. Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. Am J Med Genet B Neuropsychiatr Genet 117B: 1 â 6.
dc.identifier.citedreferenceTiihonen J, Rautiainen M, Ollila HM, Repoâ Tiihonen E, Virkkunen M, Palotie A, Pietiläinen O, Kristiansson K, Joukamaa M, Lauerma H, Saarela J, Tyni S, Vartiainen H, Paananen J, Goldman D, Paunio T. 2015. Genetic background of extreme violent behavior. Mol Psychiatry 20: 786 â 792.
dc.identifier.citedreferenceTsai S, Hong C, Liou Y, Yu YW, Chen T, Hou S, Yen F. 2009. Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Prog Neuropsychopharmacol Biol Psychiatry 33: 637 â 641.
dc.identifier.citedreferenceUddin M, Koenen KC, de Los Santos R, Bakshis E, Aiello AE, Galea S. 2010. Gender differences in the genetic and environmental determinants of adolescent depression. Depress Anxiety 27: 658 â 666.
dc.identifier.citedreferenceUstün TB, Ayusoâ Mateos J, Chatterji S, Mathers C, Murray CJL. 2004. Global burden of depressive disorders in the year 2000. Br J Psychiatry 184: 386 â 392.
dc.identifier.citedreferenceUtge S, Soronen P, Partonen T, Loukola A, Kronholm E, Pirkola S, Nyman E, Porkkaâ Heiskanen T, Paunio T. 2010. A populationâ based association study of candidate genes for depression and sleep disturbance. Am J Med Genet B Neuropsychiatr Genet 153B: 468 â 476.
dc.identifier.citedreferenceVaillant GE, Batalden M, Orav J, Roston D, Barrett JE. 2005. Evidence for a possibly Xâ linked trait related to affective illness. Aust N Z J Psychiatry 39: 730 â 735.
dc.identifier.citedreferenceVan Den Bogaert A, Sleegers K, De Zutter S, Heyrman L, Norrback K, Adolfsson R, Van Broeckhoven C, Delâ Favero J. 2006. Association of brainâ specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. Arch Gen Psychiatry 63: 1103 â 1110.
dc.identifier.citedreferencevan Strien T, van der Zwaluw CS, Engels RC. 2010. Emotional eating in adolescents: a gene (SLC6A4/5â HTT) â depressive feelings interaction analysis. J Psychiatr Res 44: 1035 â 1042.
dc.identifier.citedreferenceVerhoeven FEA, Booij L, Kruijt A, Cerit H, Antypa N, Does W. 2012. The effects of MAOA genotype, childhood trauma, and sex on trait and stateâ dependent aggression. Brain Behav 2: 806 â 813.
dc.identifier.citedreferenceVerona E, Joiner TE, Johnson F, Bender TW. 2006. Genderâ specific geneâ environment interactions on laboratoryâ assessed aggression. Biol Psychol 71: 33 â 41.
dc.identifier.citedreferenceVidebech P, Ravnkilde B. 2004. Hippocampal volume and depression: a metaâ analysis of MRI studies. Am J Psychiatry 161: 1957 â 1966.
dc.identifier.citedreferenceViikki M, Kampman O, Illi A, Setäläâ Soikkeli E, Anttila S, Huuhka M, Nuolivirta T, Poutanen O, Mononen N, Lehtimäki T, Leinonen E. 2010. TPH1â 218A/C polymorphism is associated with major depressive disorder and its treatment response. Neurosci Lett 468: 80 â 84.
dc.identifier.citedreferenceVolf NV, Belousova LV, Knyazev GG, Kulikov AV. 2015. Gender differences in association between serotonin transporter gene polymorphism and restingâ state EEG activity. Neuroscience 284: 513 â 521.
dc.identifier.citedreferenceVoltas N, Aparicio E, Arija V, Canals J. 2015. Association study of monoamine oxidaseâ A gene promoter polymorphism (MAOAâ uVNTR) with selfâ reported anxiety and other psychopathological symptoms in a community sample of early adolescents. J Anxiety Disord 31: 65 â 72.
dc.identifier.citedreferenceVormfelde SV, Hoell I, Tzvetkov M, Jamrozinski K, Sehrt D, Brockmöller J, Leibing E. 2006. Anxietyâ and novelty seekingâ related personality traits and serotonin transporter gene polymorphisms. J Psychiatr Res 40: 568 â 576.
dc.identifier.citedreferenceVrshekâ Schallhorn S, Stroud CB, Mineka S, Zinbarg RE, Adam EK, Redei EE, Hammen C, Craske MG. 2015. Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression. J Abnorm Psychol 124: 776 â 790.
dc.identifier.citedreferenceWakschlag LS, Kistner EO, Pine DS, Biesecker G, Pickett KE, Skol AD, Dukic V, Blair RJR, Leventhal BL, Cox NJ, Burns JL, Kasza KE, Wright RJ, Cook EH. 2010. Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. Mol Psychiatry 15: 928 â 937.
dc.identifier.citedreferenceWalderhaug E, Magnusson A, Neumeister A, Lappalainen J, Lunde H, Refsum H, Landrø NI. 2007. Interactive effects of sex and 5â HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biol Psychiatry 62: 593 â 599.
dc.identifier.citedreferenceWalderhaug E, Herman AI, Magnusson A, Morgan MJ, Landrø NI. 2010. The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men. Neurosci Lett 473: 208 â 211.
dc.identifier.citedreferenceWankerl M, Zyriax B, Bondy B, Hinkelmann K, Windler E, Otte C. 2010. Serotonin transporter geneâ linked polymorphic region (5â HTTLPR) and diurnal cortisol: a sex by genotype interaction. Biol Psychol 85: 344 â 346.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
jnr23877.pdf
Size:
821.2KB
Format:
PDF
View/Open
Name:
jnr23877_am.pdf
Size:
1.319MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.