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Dopamine D1 receptor expression is bipolar cell typeâ specific in the mouse retina

dc.contributor.authorFarshi, Pershang
dc.contributor.authorFyk‐kolodziej, Bozena
dc.contributor.authorKrolewski, David M.
dc.contributor.authorWalker, Paul D.
dc.contributor.authorIchinose, Tomomi
dc.date.accessioned2017-06-16T20:15:01Z
dc.date.available2017-09-06T14:20:20Zen
dc.date.issued2016-07-01
dc.identifier.citationFarshi, Pershang; Fyk‐kolodziej, Bozena ; Krolewski, David M.; Walker, Paul D.; Ichinose, Tomomi (2016). "Dopamine D1 receptor expression is bipolar cell typeâ specific in the mouse retina." Journal of Comparative Neurology 524(10): 2059-2079.
dc.identifier.issn0021-9967
dc.identifier.issn1096-9861
dc.identifier.urihttps://hdl.handle.net/2027.42/137524
dc.description.abstractIn the retina, dopamine is a key molecule for daytime vision. Dopamine is released by retinal dopaminergic amacrine cells and transmits signaling either by conventional synaptic or by volume transmission. By means of volume transmission, dopamine modulates all layers of retinal neurons; however, it is not well understood how dopamine modulates visual signaling pathways in bipolar cells. Here we analyzed Drd1aâ tdTomato BAC transgenic mice and found that the dopamine D1 receptor (D1R) is expressed in retinal bipolar cells in a typeâ dependent manner. Strong tdTomato fluorescence was detected in the inner nuclear layer and localized to type 1, 3b, and 4 OFF bipolar cells and type 5â 2, XBC, 6, and 7 ON bipolar cells. In contrast, type 2, 3a, 5â 1, 9, and rod bipolar cells did not express Drd1aâ tdTomato. Other interneurons were also found to express tdTomato including horizontal cells and a subset (25%) of AII amacrine cells. Diverse visual processing pathways, such as color or motionâ coded pathways, are thought to be initiated in retinal bipolar cells. Our results indicate that dopamine sculpts bipolar cell performance in a typeâ dependent manner to facilitate daytime vision. J. Comp. Neurol. 524:2059â 2079, 2016. © 2015 Wiley Periodicals, Inc.Using Drd1aâ tdTomato BAC transgenic mice, authors investigated dopamine D1 receptor localization in retinal bipolar cells. Both ON and OFF bipolar cells express D1 receptors in a typeâ dependent manner.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherRRID: AB_10013483
dc.subject.otherRRID: AB_94936
dc.subject.otherBAC transgenic mice
dc.subject.otherimmunohistochemistry
dc.subject.otherRRID: AB_2115181
dc.subject.otherin situ hybridization: RRID: AB_10000347
dc.subject.otherRRID: AB_2313634
dc.subject.otherRRID: AB_10013783
dc.subject.otherRRID: AB_2201528
dc.subject.otherRRID: AB_2086774
dc.subject.otherRRID: AB_2094841
dc.subject.otherRRID: AB_2314280
dc.subject.otherRRID: AB_2248534
dc.subject.otherRRID: AB_2314947
dc.subject.otherRRID: AB_2158332
dc.subject.otherRRID: AB_397957
dc.subject.otherRRID: AB_628142
dc.subject.otherRRID: AB_2261205
dc.subject.otherRRID: AB_2079751
dc.titleDopamine D1 receptor expression is bipolar cell typeâ specific in the mouse retina
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelEcology and Evolutionary Biology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137524/1/cne23932.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137524/2/cne23932_am.pdf
dc.identifier.doi10.1002/cne.23932
dc.identifier.sourceJournal of Comparative Neurology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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