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Biventricular function on early echocardiograms in neonatal hypoxic–ischaemic encephalopathy
dc.contributor.authorAggarwal, Sanjeev
dc.contributor.authorNatarajan, Girija
dc.date.accessioned2017-06-16T20:15:54Z
dc.date.available2018-08-28T15:28:59Zen
dc.date.issued2017-07
dc.identifier.citationAggarwal, Sanjeev; Natarajan, Girija (2017). "Biventricular function on early echocardiograms in neonatal hypoxic–ischaemic encephalopathy." Acta Paediatrica 106(7): 1085-1090.
dc.identifier.issn0803-5253
dc.identifier.issn1651-2227
dc.identifier.urihttps://hdl.handle.net/2027.42/137559
dc.description.abstractAimTo compare early (<24 hours) echocardiograms (ECHOs) in infants with perinatal hypoxic–ischaemic encephalopathy (HIE) undergoing (i) therapeutic hypothermia (TH), (ii) normothermia and (iii) normal controls.MethodsThis was a single‐centre retrospective review of clinical early ECHOs of term infants with moderate or severe HIE and controls (with a normal ECHO <72 hours of age). Right (RVO) and left ventricular output (LVO), RV and LV myocardial performance index (MPI), systolic to diastolic duration ratio (S/D) and eccentricity indices (EI) in systole and diastole were compared using ANOVA.ResultsAmong infants with HIE (n = 56, 38 in the TH and 18 in normothermia groups), 14 (25%) infants died and 42 survived. Significantly elevated biventricular MPI, lower RVO and LVO and pulmonary hypertension (abnormal EI, higher RV S/D and bidirectional or right‐to‐left ductal shunt) were found in groups with HIE, compared to controls (n = 35). LV MPI was lower in HIE‐TH, compared to the HIE‐normothermia group. Infants with HIE who died (n = 14) had a significantly lower EId [0.77 (0.09) vs. 0.83 (0.08), p = 0.021] compared to survivors (n = 42).ConclusionInfants with perinatal HIE have ventricular dysfunction; those who died had significantly lower EId than survivors; this association needs to be further validated.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherPulmonary hypertension
dc.subject.otherHypoxic–ischaemic encephalopathy
dc.subject.otherEchocardiogram
dc.titleBiventricular function on early echocardiograms in neonatal hypoxic–ischaemic encephalopathy
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPediatrics
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137559/1/apa13866_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137559/2/apa13866.pdf
dc.identifier.doi10.1111/apa.13866
dc.identifier.sourceActa Paediatrica
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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