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Stability of methylation markers in head and neck squamous cell carcinoma
dc.contributor.authorVirani, Shama
dc.contributor.authorLight, Emily
dc.contributor.authorPeterson, Lisa A.
dc.contributor.authorSartor, Maureen A.
dc.contributor.authorTaylor, Jeremy M. G.
dc.contributor.authorMcHugh, Jonathan B.
dc.contributor.authorWolf, Gregory T.
dc.contributor.authorRozek, Laura S.
dc.date.accessioned2017-06-16T20:16:14Z
dc.date.available2017-06-16T20:16:14Z
dc.date.issued2016-04
dc.identifier.citationVirani, Shama; Light, Emily; Peterson, Lisa A.; Sartor, Maureen A.; Taylor, Jeremy M. G.; McHugh, Jonathan B.; Wolf, Gregory T.; Rozek, Laura S. (2016). "Stability of methylation markers in head and neck squamous cell carcinoma." Head & Neck 38(S1): E1325-E1331.
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.urihttps://hdl.handle.net/2027.42/137576
dc.description.abstractBackgroundAs cancer progresses, methylation patterns change to promote the tumorigenic phenotype. However, stability of methylation markers over time and the extent that biopsy samples are representative of larger tumor specimens are unknown. This information is critical for clinical use of such biomarkers.MethodsNinety‐eight patients with tumor specimens from 2 timepoints were measured for DNA methylation in the promoter regions across 4 genes.ResultsThere were no significant differences in overall methylation of CCNA1 (cyclin A1), NDN (necdin), deleted in colorectal carcinoma (DCC), and cluster of differentiation 1a (CD1A) within paired specimens (p values = .56, .17, .66, and .58, respectively). All genes showed strong correlations between paired specimens across time. Methylation was most consistent for CCNA1 and NDN over time.ConclusionThis report provides the first evidence that methylation markers measured in biopsy samples are representative of gene methylation in later specimens and suggests that biopsy markers could be representative biomarkers for use in defining personalized treatment utilizing epigenetic changes. © 2015 Wiley Periodicals, Head Neck 38: E1325–E1331, 2016
dc.publisherWiley Periodicals, Inc.
dc.subject.otherDNA methylation
dc.subject.otherhead and neck cancer
dc.subject.otherstability
dc.subject.othertime
dc.subject.othertumor
dc.titleStability of methylation markers in head and neck squamous cell carcinoma
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137576/1/hed24223.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/137576/2/hed24223_am.pdf
dc.identifier.doi10.1002/hed.24223
dc.identifier.sourceHead & Neck
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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