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Improving antiretroviral therapy adherence in resourceâ limited settings at scale: a discussion of interventions and recommendations
dc.contributor.authorHaberer, Jessica E.
dc.contributor.authorSabin, Lora
dc.contributor.authorAmico, K. Rivet
dc.contributor.authorOrrell, Catherine
dc.contributor.authorGalárraga, Omar
dc.contributor.authorTsai, Alexander C.
dc.contributor.authorVreeman, Rachel C.
dc.contributor.authorWilson, Ira
dc.contributor.authorSam‐agudu, Nadia A.
dc.contributor.authorBlaschke, Terrence F.
dc.contributor.authorVrijens, Bernard
dc.contributor.authorMellins, Claude A.
dc.contributor.authorRemien, Robert H.
dc.contributor.authorWeiser, Sheri D.
dc.contributor.authorLowenthal, Elizabeth
dc.contributor.authorStirratt, Michael J.
dc.contributor.authorSow, Papa Salif
dc.contributor.authorThomas, Bruce
dc.contributor.authorFord, Nathan
dc.contributor.authorMills, Edward
dc.contributor.authorLester, Richard
dc.contributor.authorNachega, Jean B.
dc.contributor.authorBwana, Bosco Mwebesa
dc.contributor.authorSsewamala, Fred
dc.contributor.authorMbuagbaw, Lawrence
dc.contributor.authorMunderi, Paula
dc.contributor.authorGeng, Elvin
dc.contributor.authorBangsberg, David R.
dc.date.accessioned2017-10-05T18:17:47Z
dc.date.available2018-04-02T18:03:22Zen
dc.date.issued2017-01
dc.identifier.citationHaberer, Jessica E.; Sabin, Lora; Amico, K. Rivet; Orrell, Catherine; Galárraga, Omar ; Tsai, Alexander C.; Vreeman, Rachel C.; Wilson, Ira; Sam‐agudu, Nadia A. ; Blaschke, Terrence F.; Vrijens, Bernard; Mellins, Claude A.; Remien, Robert H.; Weiser, Sheri D.; Lowenthal, Elizabeth; Stirratt, Michael J.; Sow, Papa Salif; Thomas, Bruce; Ford, Nathan; Mills, Edward; Lester, Richard; Nachega, Jean B.; Bwana, Bosco Mwebesa; Ssewamala, Fred; Mbuagbaw, Lawrence; Munderi, Paula; Geng, Elvin; Bangsberg, David R. (2017). "Improving antiretroviral therapy adherence in resourceâ limited settings at scale: a discussion of interventions and recommendations." Journal of the International AIDS Society 20(1): n/a-n/a.
dc.identifier.issn1758-2652
dc.identifier.issn1758-2652
dc.identifier.urihttps://hdl.handle.net/2027.42/138283
dc.description.abstractIntroduction: Successful populationâ level antiretroviral therapy (ART) adherence will be necessary to realize both the clinical and prevention benefits of antiretroviral scaleâ up and, ultimately, the end of AIDS. Although many people living with HIV are adhering well, others struggle and most are likely to experience challenges in adherence that may threaten virologic suppression at some point during lifelong therapy. Despite the importance of ART adherence, supportive interventions have generally not been implemented at scale. The objective of this review is to summarize the recommendations of clinical, research, and public health experts for scalable ART adherence interventions in resourceâ limited settings.Methods: In July 2015, the Bill and Melinda Gates Foundation convened a meeting to discuss the most promising ART adherence interventions for use at scale in resourceâ limited settings. This article summarizes that discussion with recent updates. It is not a systematic review, but rather provides practical considerations for programme implementation based on evidence from individual studies, systematic reviews, metaâ analyses, and the World Health Organization Consolidated Guidelines for HIV, which include evidence from randomized controlled trials in lowâ and middleâ income countries. Interventions are categorized broadly as education and counselling; information and communication technologyâ enhanced solutions; healthcare delivery restructuring; and economic incentives and social protection interventions. Each category is discussed, including descriptions of interventions, current evidence for effectiveness, and what appears promising for the near future. Approaches to intervention implementation and impact assessment are then described.Results and discussion: The evidence base is promising for currently available, effective, and scalable ART adherence interventions for resourceâ limited settings. Numerous interventions build on existing health care infrastructure and leverage available resources. Those most widely studied and implemented to date involve peer counselling, adherence clubs, and short message service (SMS). Many additional interventions could have an important impact on ART adherence with further development, including standardized counselling through multiâ media technology, electronic dose monitoring, decentralized and differentiated models of care, and livelihood interventions. Optimal targeting and tailoring of interventions will require improved adherence measurement.Conclusions: The opportunity exists today to address and resolve many of the challenges to effective ART adherence, so that they do not limit the potential of ART to help bring about the end of AIDS.
dc.publisherWiley Periodicals, Inc.
dc.publisherTaylor & Francis
dc.subject.otherHIV
dc.subject.otherantiretroviral therapy adherence
dc.subject.otherinterventions
dc.subject.otherresourceâ limited settings
dc.titleImproving antiretroviral therapy adherence in resourceâ limited settings at scale: a discussion of interventions and recommendations
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMicrobiology and Immunology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.contributor.affiliationumDepartment of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI, USA
dc.contributor.affiliationotherDepartment of Health Services, Policy and Practice, Brown University School of Public Health, Providence, RI, USA
dc.contributor.affiliationotherDepartment of Medicine, Harvard Medical School, Boston, MA, USA
dc.contributor.affiliationotherDepartment of Global Health, Center for Global Health and Department, Boston University School of Public Health, Boston, MA, USA
dc.contributor.affiliationotherDesmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, and Department of Medicine, University of Cape Town, Cape Town, South Africa
dc.contributor.affiliationotherDepartment of Medicine and Clinical Pharmacology, Stanford University School of Medicine, Stanford, CA, USA
dc.contributor.affiliationotherInstitute of Human Virology and Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
dc.contributor.affiliationotherClinical Department, Institute of Human Virology Nigeria, Abuja, Nigeria
dc.contributor.affiliationotherAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya
dc.contributor.affiliationotherDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
dc.contributor.affiliationotherChester M. Pierce, MD Division of Global Psychiatry, Massachusetts General Hospital, Boston, MA, USA
dc.contributor.affiliationotherMassachusetts General Hospital Global Health, Boston, MA, USA
dc.contributor.affiliationotherOregon Health & Sciences Universityâ Portland State University School of Public Health, Portland, OR, USA
dc.contributor.affiliationotherDivision of HIV, Infectious Disease and Global Medicine, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, CA, USA
dc.contributor.affiliationotherHIV Care Research Program, Medical Research Council, Uganda Virus Research Institute, Entebbe, Uganda
dc.contributor.affiliationotherDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada
dc.contributor.affiliationotherColumbia University School of Social Work & School of International and Public Affairs, New York, NY, USA
dc.contributor.affiliationotherDepartment of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
dc.contributor.affiliationotherDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
dc.contributor.affiliationotherDivision of Infectious Diseases, Department of Medicine, University of British Columbia
dc.contributor.affiliationotherFaculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
dc.contributor.affiliationotherDepartment of HIV/AIDS, World Health Organization, Geneva, Switzerland
dc.contributor.affiliationotherThe Arcady Group, LLC, Richmond, VA, USA
dc.contributor.affiliationotherDepartment of Infectious diseases, University of Dakar, Dakar, Sénégal
dc.contributor.affiliationotherBill and Melinda Gates Foundation, Seattle, WA, USA
dc.contributor.affiliationotherDivision of AIDS Research, National Institute of Mental Health, Bethesda, MD, USA
dc.contributor.affiliationotherDepartments of Pediatrics and Epidemiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
dc.contributor.affiliationotherDivision of HIV, ID and Global Medicine, Department of Medicine, University of California, San Francisco, CA, USA
dc.contributor.affiliationotherHIV Center for Clinical and Behavioral Studies, NYSPI and Department of Psychiatry, Columbia; University, New York, NY, USA
dc.contributor.affiliationotherWestRock Healthcare, Sion, Switzerland
dc.contributor.affiliationotherDepartment of Biostatistics, University of Liège, Liège, Wallonia, Belgium
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/138283/1/jia21371.pdf
dc.identifier.doi10.7448/IAS.20.1.21371
dc.identifier.sourceJournal of the International AIDS Society
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Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

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