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Epigenomeâ wide association of PTSD from heterogeneous cohorts with a common multiâ site analysis pipeline
dc.contributor.authorRatanatharathorn, Andrew
dc.contributor.authorBoks, Marco P.
dc.contributor.authorMaihofer, Adam X.
dc.contributor.authorAiello, Allison E.
dc.contributor.authorAmstadter, Ananda B.
dc.contributor.authorAshley‐koch, Allison E.
dc.contributor.authorBaker, Dewleen G.
dc.contributor.authorBeckham, Jean C.
dc.contributor.authorBromet, Evelyn
dc.contributor.authorDennis, Michelle
dc.contributor.authorGarrett, Melanie E.
dc.contributor.authorGeuze, Elbert
dc.contributor.authorGuffanti, Guia
dc.contributor.authorHauser, Michael A.
dc.contributor.authorKilaru, Varun
dc.contributor.authorKimbrel, Nathan A.
dc.contributor.authorKoenen, Karestan C.
dc.contributor.authorKuan, Pei‐fen
dc.contributor.authorLogue, Mark W.
dc.contributor.authorLuft, Benjamin J.
dc.contributor.authorMiller, Mark W.
dc.contributor.authorMitchell, Colter
dc.contributor.authorNugent, Nicole R.
dc.contributor.authorRessler, Kerry J.
dc.contributor.authorRutten, Bart P. F.
dc.contributor.authorStein, Murray B.
dc.contributor.authorVermetten, Eric
dc.contributor.authorVinkers, Christiaan H.
dc.contributor.authorYoussef, Nagy A.
dc.contributor.authorUddin, Monica
dc.contributor.authorNievergelt, Caroline M.
dc.contributor.authorSmith, Alicia K.
dc.date.accessioned2017-10-05T18:18:17Z
dc.date.available2018-12-03T15:34:03Zen
dc.date.issued2017-09
dc.identifier.citationRatanatharathorn, Andrew; Boks, Marco P.; Maihofer, Adam X.; Aiello, Allison E.; Amstadter, Ananda B.; Ashley‐koch, Allison E. ; Baker, Dewleen G.; Beckham, Jean C.; Bromet, Evelyn; Dennis, Michelle; Garrett, Melanie E.; Geuze, Elbert; Guffanti, Guia; Hauser, Michael A.; Kilaru, Varun; Kimbrel, Nathan A.; Koenen, Karestan C.; Kuan, Pei‐fen ; Logue, Mark W.; Luft, Benjamin J.; Miller, Mark W.; Mitchell, Colter; Nugent, Nicole R.; Ressler, Kerry J.; Rutten, Bart P. F.; Stein, Murray B.; Vermetten, Eric; Vinkers, Christiaan H.; Youssef, Nagy A.; Uddin, Monica; Nievergelt, Caroline M.; Smith, Alicia K. (2017). "Epigenomeâ wide association of PTSD from heterogeneous cohorts with a common multiâ site analysis pipeline." American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(6): 619-630.
dc.identifier.issn1552-4841
dc.identifier.issn1552-485X
dc.identifier.urihttps://hdl.handle.net/2027.42/138305
dc.publisherSpringer
dc.publisherWiley Periodicals, Inc.
dc.subject.otherEWAS
dc.subject.otherstress
dc.subject.othertrauma
dc.subject.othermetaâ analysis
dc.titleEpigenomeâ wide association of PTSD from heterogeneous cohorts with a common multiâ site analysis pipeline
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/138305/1/ajmgb32568.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/138305/2/ajmgb32568_am.pdf
dc.identifier.doi10.1002/ajmg.b.32568
dc.identifier.sourceAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
dc.identifier.citedreferenceNievergelt, C. M., Maihofer, A. X., Mustapic, M., Yurgil, K. A., Schork, N. J., Miller, M. W., â ¦ O’Connor, D. T. ( 2015 ). Genomic predictors of combat stress vulnerability and resilience in US Marines: A genomeâ wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. Psychoneuroendocrinology, 51, 459 â 471.
dc.identifier.citedreferenceKubzansky, L. D., Koenen, K. C., Jones, C., & Eaton, W. W. ( 2009 ). A prospective study of posttraumatic stress disorder symptoms and coronary heart disease in women. Health Psychology, 28 ( 1 ), 125 â 130.
dc.identifier.citedreferenceKubzansky, L. D., Koenen, K. C., Spiro, A., 3rd, Vokonas, P. S., & Sparrow, D. ( 2007 ). Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Archives of General Psychiatry, 64 ( 1 ), 109 â 116.
dc.identifier.citedreferenceKundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heraviâ Moussavi, A., â ¦ Kellis, M. ( 2015 ). Integrative analysis of 111 reference human epigenomes. Nature, 518 ( 7539 ), 317 â 330.
dc.identifier.citedreferenceLi, J. Z., Absher, D. M., Tang, H., Southwick, A. M., Casto, A. M., Ramachandran, S., â ¦ Myers, R. M. ( 2008 ). Worldwide human relationships inferred from genomeâ wide patterns of variation. Science, 319 ( 5866 ), 1100 â 1104.
dc.identifier.citedreferenceLin, D. Y., Zeng, D. ( 2010 ). On the relative efficiency of using summary statistics versus individualâ level data in metaâ analysis. Biometrika, 97 ( 2 ), 321 â 332.
dc.identifier.citedreferenceLiu, P., Hwang, J. G. ( 2007 ). Quick calculation for sample size while controlling false discovery rate with application to microarray analysis. Bioinformatics, 23 ( 6 ), 739 â 746.
dc.identifier.citedreferenceLogue, M. W., Amstadter, A. B., Baker, D. G., Duncan, L., Koenen, K. C., Liberzon, I., â ¦ Ressler, K. J. ( 2015 ). The psychiatric genomics consortium posttraumatic stress disorder workgroup: Posttraumatic stress disorder enters the age of largeâ scale genomic collaboration. Neuropsychopharmacology, 40 ( 10 ), 2287 â 2297.
dc.identifier.citedreferenceLogue, M. W., Baldwin, C., Guffanti, G., Melista, E., Wolf, E. J., Reardon, A. F., â ¦ Koenen, K. C. ( 2013 ). A genomeâ wide association study of postâ traumatic stress disorder identifies the retinoidâ related orphan receptor alpha (RORA) gene as a significant risk locus. Molecular Psychiatry, 18 ( 8 ), 937 â 942.
dc.identifier.citedreferenceLong, J. S., Ervin, L. H. ( 2000 ). Using heteroscedasticity consistent standard errors in the linear regression model. The American Statistician, 54 ( 3 ), 217 â 224.
dc.identifier.citedreferenceLuft, B., Schechter, C., Kotov, R., Broihier, J., Reissman, D., Guerrera, K., â ¦ Friedmanâ Jimenez, G. ( 2012 ). Exposure, probable PTSD and lower respiratory illness among World Trade Center rescue, recovery and cleanâ up workers. Psychological Medicine, 42 ( 05 ), 1069 â 1079.
dc.identifier.citedreferenceMarot, G., Foulley, J.â L., Mayer, C.â D., & Jaffrézic, F. ( 2009 ). Moderated effect size and Pâ value combinations for microarray metaâ analyses. Bioinformatics, 25 ( 20 ), 2692 â 2699.
dc.identifier.citedreferenceMathew, T., Nordstrom, K. ( 1999 ). On the equivalence of metaâ analysis using literature and using individual patient data. Biometrics, 55 ( 4 ), 1221 â 1223.
dc.identifier.citedreferenceMaunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., â ¦ Zhao, Y. ( 2010 ). Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature, 466 ( 7303 ), 253 â 257.
dc.identifier.citedreferenceMcGowan, P. O., Sasaki, A., D’Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., â ¦ Meaney, M. J. ( 2009 ). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12 ( 3 ), 342 â 348.
dc.identifier.citedreferenceMehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., â ¦ Mercer, K. B. ( 2013 ). Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proceedings of the National Academy of Sciences, 110 ( 20 ), 8302 â 8307.
dc.identifier.citedreferenceMoser, D. A., Paoloniâ Giacobino, A., Stenz, L., Adouan, W., Manini, A., Suardi, F., â ¦ Rusconiâ Serpa, S. ( 2015 ). BDNF methylation and maternal brain activity in a violenceâ related sample. PLoS ONE, 10 ( 12 ).
dc.identifier.citedreferenceNajt, P., Fusarâ Poli, P., & Brambilla, P. ( 2011 ). Coâ occurring mental and substance abuse disorders: A review on the potential predictors and clinical outcomes. Psychiatry Research, 186 ( 2 ), 159 â 164.
dc.identifier.citedreferenceNielsen, D. A., Hamon, S., Yuferov, V., Jackson, C., Ho, A., Ott, J., & Kreek, M. J. ( 2010 ). Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Human Genetics, 127 ( 6 ), 639 â 649.
dc.identifier.citedreferenceNievergelt, C. M., Maihofer, A. X., Shekhtman, T., Libiger, O., Wang, X., Kidd, K. K., & Kidd, J. R. ( 2013 ). Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41â SNP panel. Investigative Genetics, 4 ( 1 ), 13.
dc.identifier.citedreferenceOlkin, I., Sampson, A. ( 1998 ). Comparison of metaâ analysis versus analysis of variance of individual patient data. Biometrics, 54 ( 1 ), 317 â 322.
dc.identifier.citedreferenceOrr, M., Liu, P. ( 2009 ). Sample size estimation while controlling false discovery rate for microarray experiments using the ssize. fdr package. R Journal, 1, 47 â 53.
dc.identifier.citedreferencePidsley, R., Wong, C. C., Volta, M., Lunnon, K., Mill, J., & Schalkwyk, L. C. ( 2013 ). A dataâ driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 ( 1 ), 293.
dc.identifier.citedreferencePrice, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. ( 2006 ). Principal components analysis corrects for stratification in genomeâ wide association studies. Nature Genetics, 38 ( 8 ), 904 â 909.
dc.identifier.citedreferenceReinius, L. E., Acevedo, N., Joerink, M., Pershagen, G., Dahlén, S.â E., Greco, D., â ¦ Kere, J. ( 2012 ). Differential DNA methylation in purified human blood cells: Implications for cell lineage and studies on disease susceptibility. PLoS ONE, 7 ( 7 ), 41361.
dc.identifier.citedreferenceResnick, H. S., Kilpatrick, D. G., Dansky, B. S., Saunders, B. E., & Best, C. L. ( 1993 ). Prevalence of civilian trauma and posttraumatic stress disorder in a representative national sample of women. Journal of Consulting and Clinical Psychology, 61 ( 6 ), 984.
dc.identifier.citedreferenceRessler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., â ¦ May, V. ( 2011 ). Postâ traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature, 470 ( 7335 ), 492 â 497.
dc.identifier.citedreferenceRice, L., Waters, C. E., Eccles, J., Garside, H., Sommer, P., Kay, P., â ¦ Stratford, I. ( 2008 ). Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. Journal of Endocrinology, 198 ( 3 ), 499 â 509.
dc.identifier.citedreferenceRoth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. ( 2009 ). Lasting epigenetic influence of earlyâ life adversity on the BDNF gene. Biological Psychiatry, 65 ( 9 ), 760 â 769.
dc.identifier.citedreferenceSareen, J., Houlahan, T., Cox, B. J., & Asmundson, G. J. ( 2005 ). Anxiety disorders associated with suicidal ideation and suicide attempts in the National Comorbidity Survey. The Journal of Nervous and Mental Disease, 193 ( 7 ), 450 â 454.
dc.identifier.citedreferenceSartor, C. E., Grant, J. D., Lynskey, M. T., McCutcheon, V. V., Waldron, M., Statham, D. J., â ¦ Nelson, E. C. ( 2012 ). Common heritable contributions to lowâ risk trauma, highâ risk trauma, posttraumatic stress disorder, and major depression. Archives of General Psychiatry, 69 ( 3 ), 293 â 299.
dc.identifier.citedreferenceSartor, C. E., McCutcheon, V. V., Pommer, N. E., Nelson, E. C., Grant, J. D., Duncan, A. E., â ¦ Heath, A. C. ( 2011 ). Common genetic and environmental contributions to postâ traumatic stress disorder and alcohol dependence in young women. Psychological Medicine, 41 ( 7 ), 1497 â 1505.
dc.identifier.citedreferenceSipahi, L., Wildman, D. E., Aiello, A. E., Koenen, K. C., Galea, S., Abbas, A., & Uddin, M. ( 2014 ). Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to postâ traumatic stress disorder. Psychological Medicine, 44 ( 15 ), 3165 â 3179.
dc.identifier.citedreferenceSmith, A. K., Conneely, K. N., Kilaru, V., Mercer, K. B., Weiss, T. E., Bradley, B., â ¦ Ressler, K. J. ( 2011 ). Differential immune system DNA methylation and cytokine regulation in postâ traumatic stress disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156 ( 6 ), 700 â 708.
dc.identifier.citedreferenceSmith, A. K., Kilaru, V., Kocak, M., Almli, L. M., Mercer, K. B., Ressler, K. J., â ¦ Conneely, K. N. ( 2014 ). Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type. BMC Genomics, 15 ( 1 ), 145.
dc.identifier.citedreferenceSmyth, G. K. ( 2005 ). Limma: Linear models for microarray data. Bioinformatics and computational biology solutions using R and Bioconductor. Springer, (pp. 397 â 420 ).
dc.identifier.citedreferenceStein, M. B., Jang, K. L., Taylor, S., Vernon, P. A., & Livesley, W. J. ( 2002 ). Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: A twin study. American Journal of Psychiatry, 159 ( 10 ), 1675 â 1681.
dc.identifier.citedreferenceTeschendorff, A. E., Marabita, F., Lechner, M., Bartlett, T., Tegner, J., Gomezâ Cabrero, D., & Beck, S. ( 2013 ). A betaâ mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450k DNA methylation data. Bioinformatics, 29 ( 2 ), 189 â 196.
dc.identifier.citedreferenceThompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Vasquez, A. A., Renteria, M. E., â ¦ Alzheimer’s Disease Neuroimaging Initiative ECICSYSG( 2014 ). The ENIGMA Consortium: Largeâ scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, 8 ( 2 ), 153 â 182.
dc.identifier.citedreferenceTrue, W. R., Rice, J., Eisen, S. A., Heath, A. C., Goldberg, J., Lyons, M. J., & Nowak, J. ( 1993 ). A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Archives of General Psychiatry, 50 ( 4 ), 257 â 264.
dc.identifier.citedreferenceTyrka, A. R., Price, L. H., Marsit, C., Walters, O. C., & Carpenter, L. L. ( 2012 ). Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: Preliminary findings in healthy adults. PLoS ONE, 7 ( 1 ), 30148.
dc.identifier.citedreferenceUddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de Los Santos, R., â ¦ Galea, S. ( 2010 ). Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America, 107 ( 20 ), 9470 â 9475.
dc.identifier.citedreferenceVinkers, C. H., Kalafateli, A. L., Rutten, B. P., Kas, M. J., Kaminsky, Z., Turner, J. D., & Boks, M. P. ( 2015 ). Traumatic stress and human DNA methylation: A critical review. Epigenomics, 7 ( 4 ), 593 â 608.
dc.identifier.citedreferenceWeaver, I. C. G., Cervoni, N., D’Alessio, A. C., Champagne, F. A., Seckl, J. R., Szyf, M., & Meaney, M. J. ( 2004 ). Epigenetic programming through maternal behavior. Nature Neuroscience, 7, 847 â 854.
dc.identifier.citedreferenceWeidner, C. I., Lin, Q., Koch, C. M., Eisele, L., Beier, F., Ziegler, P., ⠦ Mühleisen, T. W. ( 2014 ). Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biology, 15 ( 2 ), 1.
dc.identifier.citedreferenceWisco, B. E., Marx, B. P., Wolf, E. J., Miller, M. W., Southwick, S. M., & Pietrzak, R. H. ( 2014 ). Posttraumatic stress disorder in the US veteran population: Results from the National Health and Resilience in Veterans Study. The Journal of Clinical Psychiatry, 75 ( 12 ), 1338 â 1346.
dc.identifier.citedreferenceXian, H., Chantarujikapong, S. I., Scherrer, J. F., Eisen, S. A., Lyons, M. J., Goldberg, J., â ¦ True, W. R. ( 2000 ). Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs. Drug and Alcohol Dependence, 61 ( 1 ), 95 â 102.
dc.identifier.citedreferenceXie, P., Kranzler, H. R., Yang, C., Zhao, H., Farrer, L. A., & Gelernter, J. ( 2013 ). Genomeâ wide association study identifies new susceptibility loci for posttraumatic stress disorder. Biological Psychiatry, 74 ( 9 ), 656 â 663.
dc.identifier.citedreferenceZeileis A. ( 2004 ). Econometric computing with HC and HAC covariance matrix estimators.
dc.identifier.citedreferenceAlmli, L. M., Srivastava, A., Fani, N., Kerley, K., Mercer, K. B., Feng, H., â ¦ Ressler, K. J. ( 2014 ). Followâ up and extension of a prior genomeâ wide association study of posttraumatic stress disorder: Gene x environment associations and structural magnetic resonance imaging in a highly traumatized Africanâ American civilian population. Biological Psychiatry, 76 ( 4 ), e3.
dc.identifier.citedreferenceAryee, M. J., Jaffe, A. E., Corradaâ Bravo, H., Laddâ Acosta, C., Feinberg, A. P., Hansen, K. D., & Irizarry, R. A. ( 2014 ). Minfi: A flexible and comprehensive bioconductor package for the analysis of infinium DNA methylation microarrays. Bioinformatics, 30 ( 10 ), 1363 â 1369.
dc.identifier.citedreferenceAmerican Psychiatric Association. ( 2000 ). DSMâ IVâ TR: Diagnostic and statistical manual of mental disorders, text revision. Washington, DC: American Psychiatric Association 75.
dc.identifier.citedreferenceBarfield, R. T., Almli, L. M., Kilaru, V., Smith, A. K., Mercer, K. B., Duncan, R., â ¦ Conneely, K. N. ( 2014 ). Accounting for population stratification in DNA methylation studies. Genetic Epidemiology, 38 ( 3 ), 231 â 241.
dc.identifier.citedreferenceBenjamini, Y., Hochberg, Y. ( 1995 ). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B (Methodological), 57 ( 1 ), 289 â 300.
dc.identifier.citedreferenceBenjet, C., Bromet, E., Karam, E. G., Kessler, R. C., McLaughlin, K. A., Ruscio, A. M., â ¦ Koenen, K. C. ( 2016 ). The epidemiology of traumatic event exposure worldwide: Results from the World Mental Health Survey Consortium. Psychological Medicine, 46 ( 2 ), 327 â 343.
dc.identifier.citedreferenceBernstein, B. E., Stamatoyannopoulos, J. A., Costello, J. F., Ren, B., Milosavljevic, A., Meissner, A., â ¦ Thomson, J. A. ( 2010 ). The NIH roadmap epigenomics mapping consortium. Nature Biotechnology, 28 ( 10 ), 1045 â 1048.
dc.identifier.citedreferenceBocklandt S., Lin W., Sehl M. E., Sánchez F. J., Sinsheimer J. S., Horvath S., & Vilain E. ( 2011 ). Epigenetic predictor of age.
dc.identifier.citedreferenceBoks, M. P., Rutten, B. P., Geuze, E., Houtepen, L. C., Vermetten, E., Kaminsky, Z., & Vinkers, C. H. ( 2016 ). SKA2 methylation is involved in cortisol stress reactivity and predicts the development of postâ traumatic stress disorder (PTSD) after military deployment. Neuropsychopharmacology, 41 ( 5 ), 1350 â 1356.
dc.identifier.citedreferenceBonasio, R., Tu, S., & Reinberg, D. ( 2010 ). Molecular signals of epigenetic states. Science, 330 ( 6004 ), 612 â 616.
dc.identifier.citedreferenceBoscarino, J. A. ( 2008 ). A prospective study of PTSD and earlyâ age heart disease mortality among Vietnam veterans: Implications for surveillance and prevention. Psychosomatic Medicine, 70 ( 6 ), 668 â 676.
dc.identifier.citedreferenceBrady, K. T., Killeen, T. K., Brewerton, T., & Lucerini, S. ( 2000 ). Comorbidity of psychiatric disorders and posttraumatic stress disorder. Journal of Clinical Psychiatry, 61 ( Suppl7 ), 22 â 32.
dc.identifier.citedreferenceBreslau, N., Kessler, R. C., Chilcoat, H. D., Schultz, L. R., Davis, G. C., & Andreski, P. ( 1998 ). Trauma and posttraumatic stress disorder in the community: The 1996 Detroit Area Survey of Trauma. Archives of General Psychiatry, 55 ( 7 ), 626 â 632.
dc.identifier.citedreferenceChang, S.â C., Koenen, K. C., Galea, S., Aiello, A. E., Soliven, R., Wildman, D. E., & Uddin, M. ( 2012 ). Molecular variation at the SLC6A3 locus predicts lifetime risk of PTSD in the Detroit Neighborhood Health Study. PLoS ONE, 7 ( 6 ), e39184.
dc.identifier.citedreferenceCoughlin, S. S. ( 2011 ). Postâ traumatic stress disorder and cardiovascular disease. The Open Cardiovascular Medicine Journal, 5, 164 â 170.
dc.identifier.citedreferenceDaskalakis, N. P., Cohen, H., Cai, G., Buxbaum, J. D., & Yehuda, R. ( 2014 ). Expression profiling associates blood and brain glucocorticoid receptor signaling with traumaâ related individual differences in both sexes. Proceedings of the National Academy of Sciences of the United States of America, 111 ( 37 ), 13529 â 13534.
dc.identifier.citedreferenceDavid, D., Woodward, C., Esquenazi, J., & Mellman, T. A. ( 2004 ). Comparison of comorbid physical illnesses among veterans with PTSD and veterans with alcohol dependence. Psychiatric Services, 55 ( 1 ), 82 â 85.
dc.identifier.citedreferenceDu, P., Zhang, X., Huang, C.â C., Jafari, N., Kibbe, W. A., Hou, L., & Lin, S. M. ( 2010 ). Comparison of Betaâ value and Mâ value methods for quantifying methylation levels by microarray analysis. BMC bioinformatics, 11 ( 1 ), 587.
dc.identifier.citedreferenceFalush, D., Stephens, M., & Pritchard, J. K. ( 2003 ). Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies. Genetics, 164 ( 4 ), 1567 â 1587.
dc.identifier.citedreferenceFeinberg, A. P. ( 2007 ). Phenotypic plasticity and the epigenetics of human disease. Nature, 447 ( 7143 ), 433 â 440.
dc.identifier.citedreferenceFortin, J.â P., Labbe, A., Lemire, M., Zanke, B. W., Hudson, T. J., Fertig, E. J., â ¦ Hansen, K. D. ( 2014 ). Functional normalization of 450k methylation array data improves replication in large cancer studies. Genome Biology, 15 ( 11 ), 503.
dc.identifier.citedreferenceGibbs, J. R., van der Brug, M. P., Hernandez, D. G., Traynor, B. J., Nalls, M. A., Lai, S.â L., â ¦ Troncoso, J. ( 2010 ). Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genetics, 6 ( 5 ), e1000952.
dc.identifier.citedreferenceGuffanti, G., Galea, S., Yan, L., Roberts, A. L., Solovieff, N., Aiello, A. E., â ¦ Koenen, K. C. ( 2013 ). Genomeâ wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for postâ traumatic stress disorder in women. Psychoneuroendocrinology, 38 ( 12 ), 3029 â 3038.
dc.identifier.citedreferenceGuintivano, J., Brown, T., Newcomer, A., Jones, M., Cox, O., Maher, B. S., â ¦ Kaminsky, Z. A. ( 2014 ). Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. American Journal of Psychiatry, 171 ( 12 ), 1287 â 1296.
dc.identifier.citedreferenceHannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., â ¦ Gao, Y. ( 2013 ). Genomeâ wide methylation profiles reveal quantitative views of human aging rates. Molecular Cell, 49 ( 2 ), 359 â 367.
dc.identifier.citedreferenceHarper, K. N., Peters, B. A., & Gamble, M. V. ( 2013 ). Batch effects and pathway analysis: Two potential perils in cancer studies involving DNA methylation array analysis. Cancer Epidemiology Biomarkers & Prevention, 22 ( 6 ), 1052 â 1060.
dc.identifier.citedreferenceHeppner, P. S., Crawford, E. F., Haji, U. A., Afari, N., Hauger, R. L., Dashevsky, B. A., â ¦ Baker, D. G. ( 2009 ). The association of posttraumatic stress disorder and metabolic syndrome: A study of increased health risk in veterans. BMC Medicine, 7, 1.
dc.identifier.citedreferenceHeyn, H., Moran, S., Hernandoâ Herraez, I., Sayols, S., Gomez, A., Sandoval, J., â ¦ Wang, L. ( 2013 ). DNA methylation contributes to natural human variation. Genome Research, 23 ( 9 ), 1363 â 1372.
dc.identifier.citedreferenceHorvath, S. ( 2013 ). DNA methylation age of human tissues and cell types. Genome Biology, 14 ( 10 ), R115.
dc.identifier.citedreferenceHorvath, S., Zhang, Y., Langfelder, P., Kahn, R. S., Boks, M., van Eijk, K., â ¦ Ophoff, R. A. ( 2012 ). Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biology, 13 ( 10 ), R97.
dc.identifier.citedreferenceHouseman, E. A., Accomando, W. P., Koestler, D. C., Christensen, B. C., Marsit, C. J., Nelson, H. H., â ¦ Kelsey, K. T. ( 2012 ). DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics, 13 ( 1 ), 1.
dc.identifier.citedreferenceJaffe, A. E., Irizarry, R. A. ( 2014 ). Accounting for cellular heterogeneity is critical in epigenomeâ wide association studies. Genome Biology, 15 ( 2 ), R31.
dc.identifier.citedreferenceJakovljevic, M., Babic, D., Crncevic, Z., Martinac, M., Maslov, B., & Topic, R. ( 2008 ). Metabolic syndrome and depression in war veterans with postâ traumatic stress disorder. Psychiatria Danubina, 20 ( 3 ), 406 â 410.
dc.identifier.citedreferenceJirtle, R. L., Skinner, M. K. ( 2007 ). Environmental epigenomics and disease susceptibility. Nature Reviews: Genetics, 8 ( 4 ), 253 â 262.
dc.identifier.citedreferenceJohnson, W. E., Li, C., & Rabinovic, A. ( 2007 ). Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics, 8 ( 1 ), 118 â 127.
dc.identifier.citedreferenceKessler, R. C. ( 2000 ). Posttraumatic stress disorder: The burden to the individual and to society. The Journal of Clinical Psychiatry, 61 ( suppl 5 ), 4 â 12.
dc.identifier.citedreferenceKessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. ( 2005 ). Lifetime prevalence and ageâ ofâ onset distributions of DSMâ IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62 ( 6 ), 593 â 602.
dc.identifier.citedreferenceKoenen, K. C., Uddin, M., Chang, S. C., Aiello, A. E., Wildman, D. E., Goldmann, E., & Galea, S. ( 2011 ). SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depression and Anxiety, 28 ( 8 ), 639 â 647.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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