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Progranulin regulates neurogenesis in the developing vertebrate retina
dc.contributor.authorWalsh, Caroline E.
dc.contributor.authorHitchcock, Peter F.
dc.date.accessioned2017-10-05T18:19:24Z
dc.date.available2018-12-03T15:34:03Zen
dc.date.issued2017-09
dc.identifier.citationWalsh, Caroline E.; Hitchcock, Peter F. (2017). "Progranulin regulates neurogenesis in the developing vertebrate retina." Developmental Neurobiology 77(9): 1114-1129.
dc.identifier.issn1932-8451
dc.identifier.issn1932-846X
dc.identifier.urihttps://hdl.handle.net/2027.42/138360
dc.description.abstractWe evaluated the expression and function of the microglia‐specific growth factor, Progranulin‐a (Pgrn‐a) during developmental neurogenesis in the embryonic retina of zebrafish. At 24 hpf pgrn‐a is expressed throughout the forebrain, but by 48 hpf pgrn‐a is exclusively expressed by microglia and/or microglial precursors within the brain and retina. Knockdown of Pgrn‐a does not alter the onset of neurogenic programs or increase cell death, however, in its absence, neurogenesis is significantly delayed—retinal progenitors fail to exit the cell cycle at the appropriate developmental time and postmitotic cells do not acquire markers of terminal differentiation, and microglial precursors do not colonize the retina. Given the link between Progranulin and cell cycle regulation in peripheral tissues and transformed cells, we analyzed cell cycle kinetics among retinal progenitors following Pgrn‐a knockdown. Depleting Pgrn‐a results in a significant lengthening of the cell cycle. These data suggest that Pgrn‐a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina. Collectively, these data show that Pgrn‐a governs neurogenesis by regulating cell cycle kinetics and the transition from proliferation to cell cycle exit and differentiation. © 2017 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 77: 1114–1129, 2017
dc.publisherWiley Periodicals, Inc.
dc.subject.otherzebrafish
dc.subject.othercell cycle
dc.subject.otherCNS development
dc.subject.otherretinal development
dc.subject.otherProgranulin‐a
dc.titleProgranulin regulates neurogenesis in the developing vertebrate retina
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/138360/1/dneu22499.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/138360/2/dneu22499_am.pdf
dc.identifier.doi10.1002/dneu.22499
dc.identifier.sourceDevelopmental Neurobiology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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