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Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: A randomized controlled, clinical trial
dc.contributor.authorBajestan, Mona N.
dc.contributor.authorRajan, Archana
dc.contributor.authorEdwards, Sean P.
dc.contributor.authorAronovich, Sharon
dc.contributor.authorCevidanes, Lucia H. S.
dc.contributor.authorPolymeri, Angeliki
dc.contributor.authorTravan, Suncica
dc.contributor.authorKaigler, Darnell
dc.date.accessioned2017-10-23T17:31:00Z
dc.date.available2018-12-03T15:34:05Zen
dc.date.issued2017-10
dc.identifier.citationBajestan, Mona N.; Rajan, Archana; Edwards, Sean P.; Aronovich, Sharon; Cevidanes, Lucia H. S.; Polymeri, Angeliki; Travan, Suncica; Kaigler, Darnell (2017). "Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: A randomized controlled, clinical trial." Clinical Implant Dentistry and Related Research 19(5): 793-801.
dc.identifier.issn1523-0899
dc.identifier.issn1708-8208
dc.identifier.urihttps://hdl.handle.net/2027.42/138871
dc.description.abstractBackgroundStem cell therapy with bone marrow‐derived mesenchymal stem cells is a promising tissue engineering strategy to promote regeneration of craniofacial bone.PurposeTo determine whether cell therapy with ex vivo expanded stem cell populations would be safe and efficacious in the regeneration of large alveolar defects in patients with a history of cleft palate or craniofacial trauma.Materials and MethodsEighteen patients (10 patients with traumatic injury and 8 patients with cleft palate) presenting with missing teeth associated with horizontal alveolar bone deficiencies were included in this randomized controlled clinical trial. Patients were randomized to receive either conventional autogenous block grafts or stem cell therapy. After a healing period of 4 months the treated sites were re‐entered and the bone width re‐assessed prior to implant placement. Implant stability was evaluated through torque testing of the implant upon insertion and at 6 months postloading.ResultsThe mean gain in bone width was 1.5 ± 1.5 mm in the stem cell therapy group and 3.3 ± 1.4 mm in the control group. Overall, bone gain was higher in trauma patients as compared to patients with cleft palate, for both the control and the stem cell therapy groups. Most postoperative complications were wound dehiscences and incision line openings. Implants were placed successfully in 5 out of 10 patients in the stem cell therapy group and in all 8 patients in the control group. One implant from the control/cleft palate group failed before loading, while the rest of the implants were loaded successfully and remained stable at 6 months. The patients who did not receive implants were re‐treated with autogenous block bone graft.ConclusionThe ability of stem cells to treat large alveolar defects is safe, yet, their ability to completely reconstitute large alveolar defects is limited. This approach requires further optimization to meet the outcomes seen using current methods to treat large defects, particularly those resultant of cleft palate.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherbone regeneration
dc.subject.othercell therapy
dc.subject.othercleft
dc.subject.otherclinical trial
dc.subject.otherdental implants
dc.subject.otherreconstruction
dc.subject.otherstem cells
dc.subject.othertrauma
dc.titleStem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: A randomized controlled, clinical trial
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/138871/1/cid12506.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/138871/2/cid12506_am.pdf
dc.identifier.doi10.1111/cid.12506
dc.identifier.sourceClinical Implant Dentistry and Related Research
dc.identifier.citedreferenceBuser D, Dula K, Belser UC, Hirt HP, Berthold H. Localized ridge augmentation using guided bone regeneration. II. Surgical procedure in the mandible. Int J Periodontics Restorative Dent. 1995; 15: 10 – 29.
dc.identifier.citedreferenceKaigler D, Avila‐Ortiz G, Travan S, et al. Bone engineering of maxillary sinus bone deficiencies using enriched CD90+ stem cell therapy: A randomized clinical trial. J Bone Miner Res. 2015; 30: 1206 – 1216.
dc.identifier.citedreferenceMeijer GJ, de Bruijn JD, Koole R, van Blitterswijk CA. Cell based bone tissue engineering in jaw defects. Biomaterials. 2008; 29: 3053 – 3061.
dc.identifier.citedreferenceRajan A, Eubanks E, Edwards S, et al. Optimized cell survival and seeding efficiency for craniofacial tissue engineering using clinical stem cell therapy. Stem Cells Transl Med. 2014; 3: 1495 – 1503.
dc.identifier.citedreferenceGastens MH, Goltry K, Prohaska W, et al. Good manufacturing practice‐compliant expansion of marrow‐derived stem and progenitor cells for cell therapy. Cell Transplant. 2007; 16: 685 – 696.
dc.identifier.citedreferenceConnolly JF. Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis. Clin Orthop Relat Res. 1998; 355 (Suppl): S257 – S266.
dc.identifier.citedreferenceQuarto R, Mastrogiacomo M, Cancedda R, et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med. 2001; 344: 385 – 386.
dc.identifier.citedreferenceHernigou P, Pariat J, Queinnec S, et al. Supercharging irradiated allografts with mesenchymal stem cells improves acetabular bone grafting in revision arthroplasty. Int Orthop. 2014; 38: 1913 – 1921.
dc.identifier.citedreferenceKawate K, Yajima H, Ohgushi H, et al. Tissue‐engineered approach for the treatment of steroid‐induced osteonecrosis of the femoral head: Transplantation of autologous mesenchymal stem cells cultured with beta‐tricalcium phosphate ceramics and free vascularized fibula. Artif Organs. 2006; 30: 960 – 962.
dc.identifier.citedreferenceMarcacci M, Kon E, Moukhachev V, et al. Stem cells associated with macroporous bioceramics for long bone repair: 6‐ to 7‐year outcome of a pilot clinical study. Tissue Eng. 2007; 13: 947 – 955.
dc.identifier.citedreferenceWarnke PH, Springer IN, Wiltfang J, et al. Growth and transplantation of a custom vascularised bone graft in a man. Lancet. 2004; 364: 766 – 770.
dc.identifier.citedreferenceCarmichael RP, Sandor GK. Use of dental implants in the management of cleft lip and palate. Atlas Oral Maxillofac Surg Clin North Am. 2008; 16: 61 – 82.
dc.identifier.citedreferenceMatsui Y, Ohta M, Ohno K, Nagumo M. Alveolar bone graft for patients with cleft lip/palate using bone particles and titanium mesh: A quantitative study. J Oral Maxillofac Surg. 2006; 64: 1540 – 1545.
dc.identifier.citedreferenceKim YK, Yeo HH, Kim SG. Use of the tongue flap for intraoral reconstruction: A report of 16 cases. J Oral Maxillofac Surg. 1998; 56: 716 – 719. discussion 720–721.
dc.identifier.citedreferenceSandor GK, Carmichael RP, Brkovic BM. Dental implants placed into alveolar clefts reconstructed with tongue flaps and bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109: e1 – e7.
dc.identifier.citedreferenceWang HL, Boyapati L. PASS” principles for predictable bone regeneration. Implant Dent. 2006; 15: 8 – 17.
dc.identifier.citedreferenceBuser D, Dula K, Belser U, Hirt HP, Berthold H. Localized ridge augmentation using guided bone regeneration. 1. Surgical procedure in the maxilla. Int J Periodontics Restorative Dent. 1993; 13: 29 – 45.
dc.identifier.citedreferenceMellonig JT, Nevins M. Guided bone regeneration of bone defects associated with implants: An evidence‐based outcome assessment. Int J Periodontics Restorative Dent. 1995; 15: 168 – 185.
dc.identifier.citedreferenceArtzi Z, Weinreb M, Givol N, et al. Biomaterial resorption rate and healing site morphology of inorganic bovine bone and beta‐tricalcium phosphate in the canine: A 24‐month longitudinal histologic study and morphometric analysis. Int J Oral Maxillofac Implants. 2004; 19: 357 – 368.
dc.identifier.citedreferenceHak DJ. The use of osteoconductive bone graft substitutes in orthopaedic trauma. J Am Acad Orthop Surg. 2007; 15: 525 – 536.
dc.identifier.citedreferenceBajpai I, Kim DY, Kyong‐Jin J, Song IH, Kim S. Response of human bone marrow‐derived MSCs on triphasic Ca‐P substrate with various HA/TCP ratio. J Biomed Mater Res B Appl Biomater. 2017; 105: 72 – 80.
dc.identifier.citedreferenceHenrich D, Verboket R, Schaible A. Characterization of bone marrow mononuclear cells on biomaterials for bone tissue engineering in vitro. 2015;2015: 762407.
dc.identifier.citedreferenceBallyns JJ, Bonassar LJ. Image‐guided tissue engineering. J Cell Mol Med. 2009; 13: 1428 – 1436.
dc.identifier.citedreferencePark CH, Rios HF, Taut AD, et al. Image‐based, fiber guiding scaffolds: A platform for regenerating tissue interfaces. Tissue Eng Part C Methods. 2014; 20: 533 – 542.
dc.identifier.citedreferenceBuser D, Dula K, Hirt HP, Schenk RK. Lateral ridge augmentation using autografts and barrier membranes: A clinical study with 40 partially edentulous patients. J Oral Maxillofac Surg. 1996; 54: 420 – 432. discussion 432–433.
dc.identifier.citedreferenceda Costa CE, Pelegrine AA, Fagundes DJ, Simoes Mde J, Taha MO. Use of corticocancellous allogeneic bone blocks impregnated with bone marrow aspirate: A clinical, tomographic, and histomorphometric study. Gen Dent. 2011; 59: e200 – e205.
dc.identifier.citedreferenceDickinson BP, Ashley RK, Wasson KL, et al. Reduced morbidity and improved healing with bone morphogenic protein‐2 in older patients with alveolar cleft defects. Plast Reconstr Surg. 2008; 121: 209 – 217.
dc.identifier.citedreferencePelegrine AA, da Costa CE, Correa ME, Marques JF. Jr., Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft. Clin Oral Implants Res. 2010; 21: 535 – 542.
dc.identifier.citedreferenceMyeroff C, Archdeacon M. Autogenous bone graft: Donor sites and techniques. J Bone Joint Surg Am. 2011; 93: 2227 – 2236.
dc.identifier.citedreferenceJin LJ, Lamster I, Greenspan JS, Pitts N, Scully C, Warnakulasuriya S. Global burden of oral diseases: Emerging concepts, management and interplay with systemic health. Oral Dis. 2016; 22: 609 – 619.
dc.identifier.citedreferenceParker SE, Mai CT, Canfield MA, et al. Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004–2006. Birth Defects Res A Clin Mol Teratol. 2010; 88: 1008 – 1016.
dc.identifier.citedreferenceAl Jamal GA, Hazza’a AM, Rawashdeh MA. Prevalence of dental anomalies in a population of cleft lip and palate patients. Cleft Palate Craniofac J. 2010; 47: 413 – 420.
dc.identifier.citedreferenceGlendor U. Aetiology and risk factors related to traumatic dental injuries–a review of the literature. Dent Traumatol. 2009; 25: 19 – 31.
dc.identifier.citedreferenceSethi RK, Kozin ED, Fagenholz PJ, Lee DJ, Shrime MG, Gray ST. Epidemiological survey of head and neck injuries and trauma in the United States. Otolaryngol Head Neck Surg. 2014; 151: 776 – 784.
dc.identifier.citedreferenceEsposito M, Grusovin MG, Felice P, Karatzopoulos G, Worthington HV, Coulthard P. Interventions for replacing missing teeth: Horizontal and vertical bone augmentation techniques for dental implant treatment. Cochrane Database Syst Rev. 2009; 7: CD003607.
dc.identifier.citedreferenceBehnia H, Khojasteh A, Soleimani M, Tehranchi A, Atashi A. Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: A preliminary report. J Craniomaxillofac Surg. 2012; 40: 2 – 7.
dc.identifier.citedreferenceKaigler D, Pagni G, Park CH, et al. Stem cell therapy for craniofacial bone regeneration: A randomized, controlled feasibility trial. Cell Transplant. 2013; 22: 767 – 777.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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