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Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma
dc.contributor.authorWang, Mengmeng
dc.contributor.authorFang, Meng
dc.contributor.authorZhu, Jianhui
dc.contributor.authorFeng, Huijuan
dc.contributor.authorWarner, Elisa
dc.contributor.authorYi, Changhong
dc.contributor.authorJi, Jun
dc.contributor.authorGu, Xing
dc.contributor.authorGao, Chunfang
dc.date.accessioned2017-11-13T16:40:24Z
dc.date.available2019-01-07T18:34:39Zen
dc.date.issued2017-11
dc.identifier.citationWang, Mengmeng; Fang, Meng; Zhu, Jianhui; Feng, Huijuan; Warner, Elisa; Yi, Changhong; Ji, Jun; Gu, Xing; Gao, Chunfang (2017). "Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma." ELECTROPHORESIS 38(21): 2749-2756.
dc.identifier.issn0173-0835
dc.identifier.issn1522-2683
dc.identifier.urihttps://hdl.handle.net/2027.42/139072
dc.description.abstractExtensive efforts have been devoted to improve the diagnosis of extrahepatic cholangiocarcinoma (ECCA) due to its silent clinical character and lack of effective diagnostic biomarkers. Specific alterations in N‐glycosylation of glycoproteins are considered a key component in cancer progression, which can serve as a distinct molecular signature for cancer detection. This study aims to find potential serum N‐glycan markers for ECCA. In total, 255 serum samples from patients with ECCA (n = 106), benign bile tract disease (BBD, n = 60) and healthy controls (HC, n = 89) were recruited. Only 2 μL of serum from individual patients was used in this assay where the N‐glycome of serum glycoproteins was profiled by DNA sequencer‐assisted fluorophore‐assisted capillary electrophoresis (DSA‐FACE) technology. Multi‐parameter models were constructed by combining the N‐glycans and carbohydrate antigen 19‐9 (CA19‐9) which is currently used clinically. Quantitative analyses showed that among 13 N‐glycan structures, the bifucosylated triantennary N‐glycan (peak10, NA3F2) presented the best diagnostic performance for distinguishing ECCA from BBD and HC. Two diagnostic models (Glycotest1 and Glycotest2) performed better than single N‐glycan or CA19‐9. Additionally, two N‐glycan structures (peak9, NA3Fb; peak12, NA4Fb) were tightly related to lymph node metastasis in ECCA patients. In conclusion, sera of ECCA showed relatively specific N‐glycome profiling patterns. Serum N‐glycan markers and models are novel, valuable and noninvasive alternatives in ECCA diagnosis and progression monitoring.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherExtrahepatic cholangiocarcinoma
dc.subject.otherDiagnosis
dc.subject.otherBiomarker
dc.subject.otherN‐glycans
dc.titleSerum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biology
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbsecondlevelMaterials Science and Engineering
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelEngineering
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/139072/1/elps6272.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/139072/2/elps6272_am.pdf
dc.identifier.doi10.1002/elps.201700084
dc.identifier.sourceELECTROPHORESIS
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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